The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
Adipokines: a link between obesity and dementia?
Open accessAbstract
Being overweight or obese, as measured with body mass index (BMI) or central adiposity (waist circumference), and evolving trajectory of BMI over the life course, have been associated with brain atrophy, white matter changes, blood brain barrier integrity and risk of all-cause late-onset dementia and Alzheimer’s Disease (AD). This observation leads us to question what it is about BMI that is associated with health of the brain and dementia risk. If high BMI and central adiposity represent an increase in adipose tissue, then the endocrine aspect of adipose tissue, mediated by adipose tissue hormones and adipokines, may be a clue to understanding the association with dementia and AD. Hundreds of adipokines have been identified, creating a complexity that is challenging to simplify. Nonetheless, adipokines are being investigated in association with clinical dementia outcomes, as well as imaging-based measures of brain volume, structure and function in preclinical and human models of clinical dementia.
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Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity
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Aging, obesity, and inflammatory age-related diseases
Frasca, D., Blomberg, B. B., & Paganelli, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01745 · Cited by 371
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Nutrition for the ageing brain: Towards evidence for an optimal diet
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Self-citation
Metadata
- Authors
- Kiliaan, A. J., Arnoldussen, I. A. C., & Gustafson, D. R.
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 13
- Issue
- 9
- Pages
- 913-923
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2118226607
- Cited by
- 285
- References
- 145
- FWCI
- 16.17
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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