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Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study
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“In sporadic ALS (sALS), patients may have a genetic predisposition to develop the disease that interacts with environmental influences to produce motor neuronal degeneration and manifestation of ALS over time. 3 , 4”
From Risk factors for amyotrophic lateral sclerosis: A regional United States case‐control study (2021) · cites this paper as [3]
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Research works printed but not linked: 29
- Byrne, 2013, Aggregation of neurologic and neuropsychiatric disease in amyotrophic lateral sclerosis kindreds: a population-based case-control cohort study of familial and sporadic amyotrophic lateral sclerosis, Ann Neurol, 74, 699, 10.1002/ana.23969 · DOI
- Al-Chalabi, 2011, Modelling the effects of penetrance and family size on rates of sporadic and familial disease, Hum Hered, 71, 281, 10.1159/000330167 · DOI
- Chio, 2009, Epidemiology of ALS in Italy: a 10-year prospective population-based study, Neurology, 72, 725, 10.1212/01.wnl.0000343008.26874.d1 · DOI
- Ravits, 2009, ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration, Neurology, 73, 805, 10.1212/WNL.0b013e3181b6bbbd · DOI
- Brown, 2005, Neurodegenerative diseases: An overview of environmental risk factors, Environ Health Perspect, 113, 1250, 10.1289/ehp.7567 · DOI
- Hornsby, 2007, What can we learn from the population incidence of cancer? Armitage and Doll revisited, Lancet Oncol, 8, 1030, 10.1016/S1470-2045(07)70343-1 · DOI
- Armitage, 1954, The age distribution of cancer and a multi-stage theory of carcinogenesis, Br J Cancer, 8, 1, 10.1038/bjc.1954.1 · DOI · Paper page
- Fisher, 1951, A hypothesis for the origin of cancer foci, Cancer, 4, 916, 10.1002/1097-0142(195109)4:5<916::AID-CNCR2820040504>3.0.CO;2-7 · DOI
- Nordling, 1953, A new theory on cancer-inducing mechanism, Br J Cancer, 7, 68, 10.1038/bjc.1953.8 · DOI
- Armitage, 1954, The age distribution of cancer and a multi-stage theory of carcinogenesis, Br J Cancer, 8, 1, 10.1038/bjc.1954.1 · DOI · Paper page
- Rooney, 2013, Survival analysis of Irish amyotrophic lateral sclerosis patients diagnosed from 1995–2010, PLoS One, 8, e74733, 10.1371/journal.pone.0074733 · DOI
- Huisman, 2013, Lifetime physical activity and the risk of amyotrophic lateral sclerosis, J Neurol Neurosurg Psychiatry, 84, 976, 10.1136/jnnp-2012-304724 · DOI · Paper page
- de Jong, 2012, Smoking, alcohol consumption, and the risk of amyotrophic lateral sclerosis: a population-based study, Am J Epidemiol, 176, 233, 10.1093/aje/kws015 · DOI
- Chancellor, 1993, The prognosis of adult-onset motor neuron disease: a prospective study based on the Scottish Motor Neuron Disease Register, J Neurol, 240, 339, 10.1007/BF00839964 · DOI
- Abhinav, 2007, Amyotrophic lateral sclerosis in South-East England: a population-based study. The South-East England register for amyotrophic lateral sclerosis (SEALS Registry), Neuroepidemiology, 29, 44, 10.1159/000108917 · DOI
- Forbes, 2007, The incidence of motor nueron disease in Scotland, J Neurol, 254, 866, 10.1007/s00415-006-0454-y · DOI
- Marrie, 2010, The rising prevalence and changing age distribution of multiple sclerosis in Manitoba, Neurology, 74, 465, 10.1212/WNL.0b013e3181cf6ec0 · DOI · Paper page
- Dorn, 1959, Morbidity from cancer in the United States, Public Health Monogr, 56, 1
- Frank, 2004, Age-specific acceleration of cancer, Curr Biol, 2014, 242, 10.1016/j.cub.2003.12.026 · DOI
- Wang, 2011, Smoking and risk of amyotrophic lateral sclerosis: a pooled analysis of 5 prospective cohorts, Arch Neurol, 68, 207, 10.1001/archneurol.2010.367 · DOI
- Andersen, 2011, Clinical genetics of amyotrophic lateral sclerosis: what do we really know?, Nat Rev Neurol, 7, 603, 10.1038/nrneurol.2011.150 · DOI · Paper page
- Al-Chalabi, 2013, The epidemiology of ALS: a conspiracy of genes, environment and time, Nat Rev Neurol, 9, 617, 10.1038/nrneurol.2013.203 · DOI
- Estrin, 1977, Amyotrophic lateral sclerosis in dizygotic twins, Neurology, 27, 692, 10.1212/WNL.27.7.692 · DOI
- Frank, 2010, Evolution in health and medicine Sackler colloquium: Somatic evolutionary genomics: mutations during development cause highly variable genetic mosaicism with risk of cancer and neurodegeneration, Proc Natl Acad Sci USA, 107, 1725, 10.1073/pnas.0909343106 · DOI
- Polymenidou, 2011, The seeds of neurodegeneration: prion-like spreading in ALS, Cell, 147, 498, 10.1016/j.cell.2011.10.011 · DOI
- Plun-Favreau, 2010, Cancer and neurodegeneration: between the devil and the deep blue sea, PLoS Genet, 6, e1001257, 10.1371/journal.pgen.1001257 · DOI
- Andersen, 1997, Phenotypic heterogeneity in motor neuron disease patients with CuZn-superoxide dismutase mutations in Scandinavia, Brain, 120, 1723, 10.1093/brain/120.10.1723 · DOI
- Cudkowicz, 1997, Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis, Ann Neurol, 41, 210, 10.1002/ana.410410212 · DOI
- Byrne, 2012, Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study, Lancet Neurol, 11, 232, 10.1016/S1474-4422(12)70014-5 · DOI
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Mead, R. J., Shan, N., Reiser, H. J., Marshall, F., & Shaw, P. J. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00612-2 · Cited by 505
Amyotrophic lateral sclerosis: moving towards a new classification system
Al-Chalabi, A., Hardiman, O., Kiernan, M. C., Chiò, A., Rix-Brooks, B., & van den Berg, L. H. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30199-5 · Cited by 390
Self-citationAmyotrophic lateral sclerosis: translating genetic discoveries into therapies
Akçimen, F., Lopez, E. R., Landers, J. E., Nath, A., Chiò, A., Chia, R., & Traynor, B. J. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-023-00592-y · Cited by 234
The multistep hypothesis of ALS revisited: The role of genetic mutations
Chiò, A., Mazzini, L., D'Alfonso, S., Corrado, L., Canosa, A., Moglia, C., Manera, U., Bersano, E., Brunetti, M., Barberis, M., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000005996 · Cited by 212
Self-citationThe changing picture of amyotrophic lateral sclerosis: lessons from European registers
Hardiman, O., Al-Chalabi, A., Brayne, C., Beghi, E., van den Berg, L. H., Chio, A., Martin, S., Logroscino, G., & Rooney, J. (2017) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-314495 · Cited by 126
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Metadata
- Authors
- Al-Chalabi, A., Calvo, A., Chio, A., Colville, S., Ellis, C. M., Hardiman, O., Heverin, M., Howard, R. S., Huisman, M. H. B., Keren, N., Leigh, P. N., Mazzini, L., Mora, G., Orrell, R. W., Rooney, J., Scott, K. M., Scotton, W. J., Seelen, M., Shaw, C. E., Sidle, K. S., Swingler, R., Tsuda, M., Veldink, J. H., Visser, A. E., van den Berg, L. H., & Pearce, N.
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 13
- Issue
- 11
- Pages
- 1108-1113
- ISSN
- 1474-4422
- PMC
- PMC4197338
- Cited by
- 411
- References
- 0
- Language
- en
- Funders
- King's College London
- EU Joint Programme – Neurodegenerative Disease Research
- Adessium Foundation
- ZonMw
- Medical Research Council
- Stichting ALS Nederland
- Ministero della Salute
- Economic and Social Research Council
- Ministero dell’Istruzione, dell’Università e della Ricerca
- National Institute for Health and Care Research
- Prinses Beatrix Spierfonds (PB 0703)
- Motor Neurone Disease Association
- Seventh Framework Programme (259867)
- Baxter International
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- The paper
- Al-Chalabi, A., Calvo, A., Chio, A., Colville, S., Ellis, C. M., Hardiman, O., Heverin, M., Howard, R. S., Huisman, M. H. B., Keren, N., Leigh, P. N., Mazzini, L., Mora, G., Orrell, R. W., Rooney, J., Scott, K. M., Scotton, W. J., Seelen, M., Shaw, C. E., . . . Pearce, N. (2014). Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study. The Lancet Neurology. https://doi.org/10.1016/s1474-4422(14)70219-4