The rising prevalence and changing age distribution of multiple sclerosis in Manitoba
Abstract
Objective Several studies suggest an increasing prevalence of multiple sclerosis (MS) in Canada. We aimed to validate a case definition for MS using administrative health insurance data, and to describe the incidence and prevalence of MS in Manitoba, Canada. Methods We used provincial administrative claims data to identify persons with demyelinating disease using International Classification of Diseases 9/10 codes and prescription claims. To validate the case definition, questionnaires were mailed to 2,000 randomly selected persons with an encounter for demyelinating disease, requesting permission for medical records review. We used diagnoses abstracted from medical records as the gold standard to evaluate candidate case definitions using administrative data. Results From 1984 to 1997, cases of MS using claims data were defined as persons with > or = 7 medical contacts for MS. From 1998 onward, cases were defined as persons with > or = 3 medical contacts. As compared to medical records, this definition had a positive predictive value of 80.5% and negative predictive value of 75.5%. From 1998 to 2006, the average age- and sex-adjusted annual incidence of MS per 100,000 population was 11.4 (95% confidence interval [CI] 10.7-12.0). The age-adjusted prevalence of MS per 100,000 population increased from 32.6 (95% CI 29.4-35.8) in 1984 to 226.7 (95% CI 218.1-235.3) in 2006, with the peak prevalence shifting to older age groups. Conclusion The prevalence of multiple sclerosis (MS)…
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The rising prevalence estimates for multiple sclerosis across high-income regions and countries might mostly reflect improved survival.
“Therefore, the rising prevalence estimates for multiple sclerosis across high-income regions and countries might mostly reflect improved survival.40”
From Global, regional, and national burden of multiple sclerosis 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 (2019) · cites this paper as [40]
A validated algorithm approach to estimate prevalence and incidence in population-based health care administrative datasets has been successfully applied to North American multiple sclerosis populations.
“This approach has been successfully applied to North American multiple sclerosis populations.40, 52”
From Global, regional, and national burden of multiple sclerosis 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 (2019) · cites this paper as [40]
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Wallin, M. T., Culpepper, W. J., Nichols, E., Bhutta, Z. A., Gebrehiwot, T. T., Hay, S. I., Khalil, I. A., Krohn, K. J., Liang, X., Naghavi, M., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30443-5 · Cited by 1,108 · see citing works
for the CIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis, Marrie, R. A., Fisk, J. D., Yu, B. N., Leung, S., Elliott, L., Caetano, P., Warren, S., Evans, C., Wolfson, C., et al. (2013) · BMC Neurology · doi:10.1186/1471-2377-13-16 · Cited by 163 · see citing works
Rising incidence of psychiatric disorders before diagnosis of immune-mediated inflammatory disease
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- Authors
- Marrie, R. A., Yu, N., Blanchard, J., Leung, S., & Elliott, L.
- Affiliations
- University of Manitoba (CA)
- Venue
- Neurology
- Published
- 2010-02-09
- Volume
- 74
- Issue
- 6
- Pages
- 465-471
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2074738783
- Cited by
- 307
- References
- 2
- Citations by year
- 2026: 8 · 2025: 20 · 2024: 24 · 2023: 13 · 2022: 18 · 2021: 19 · 2020: 22 · 2019: 30 · 2018: 27 · 2017: 27 · 2016: 23 · 2015: 18 · 2014: 17 · 2013: 16 · 2012: 14
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Health Professions › Health Information Management › Medical Coding and Health Information
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Keywords
- multiple sclerosis, prevalence, incidence, case definition validation, demyelinating disease, age distribution, survival, Manitoba
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Female, Humans, Male, Manitoba, Middle Aged, Multiple Sclerosis, National Health Programs, Surveys and Questionnaires, Retrospective Studies, Reproducibility of Results, Incidence, Prevalence, Confidence Intervals, Age Distribution
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