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Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer's disease: a cross-sectional analysis of data from the Rush Memory and Aging Project
Open accessAbstract
Background Some people with substantial Alzheimer's disease pathology at autopsy had shown few characteristic clinical symptoms or signs of the disease, whereas others with little Alzheimer's disease pathology have been diagnosed with Alzheimer's dementia. We aimed to examine whether frailty, which is associated with both age and dementia, moderates the relationship between Alzheimer's disease pathology and Alzheimer's dementia.Methods We did a cross-sectional analysis of data from participants of the Rush Memory and Aging Project, a clinical-pathological cohort study of older adults (older than 59 years) without known dementia at baseline, living in Illinois, USA. Participants in the cohort study underwent annual neuropsychological and clinical evaluations. In the present cross-sectional analysis, we included those participants who did not have any form of dementia or who had Alzheimer's dementia at the time of their last clinical assessment and who had died and for whom complete autopsy data were available. Alzheimer's disease pathology was quantified by a summary measure of neurofibrillary tangles and neuritic and diffuse plaques. Clinical diagnosis of Alzheimer's dementia was based on clinician consensus. Frailty was operationalised retrospectively using health variable information obtained at each clincial evaluation using the deficit accumulation approach (41-item frailty index). Logistic regression and moderation modelling were used to assess relationships between Alzheimer's disease pathology, frailty, and Alzheimer's dementia. All analyses were adjusted for age, sex, and education.Findings Up to data cutoff (Jan 20, 2017), we included 456 participants (mean age at death 89·7 years [SD 6·1]; 316 [69%] women). 242 (53%) had a diagnosis of possible or probable Alzheimer's dementia at their last clinical assessment. Frailty (odds ratio 1·76, 95% CI 1·54-2·02; p<0·0001) and Alzheimer's disease pathology (4·81, 3·31-7·01; p<0·0001) were independently associated with Alzheimer's dementia, after adjusting for age, sex, and education. When frailty was added to the model for the relationship between Alzheimer's disease pathology and Alzheimer's dementia, model fit improved (p<0·0001). There was a significant interaction between frailty and Alzheimer's disease pathology (odds ratio 0·73, 95% CI 0·57-0·94; p interaction=0·015). People with an increased frailty score had a weakened direct link between Alzheimer's disease pathology and Alzheimer's dementia; that is, people with a low amount of frailty were better able to tolerate Alzheimer's disease pathology, whereas those with higher amounts of frailty were more likely both to have more Alzheimer's disease pathology and for it to be expressed as dementia.Interpretation The degree of frailty among people of the same age modifies the association between Alzheimer's disease pathology and Alzheimer's dementia. That frailty is related to both odds of Alzheimer's dementia and disease expression has implications for clinical management, since individuals with even a low level of Alzheimer's disease pathology might be at risk for dementia if they have high amounts of frailty. Further research should assess how frailty and cognition change over time to better elucidate this complex relationship.Funding None.
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“People in otherwise good physical health can sustain a higher burden of neuropathology without cognitive impairment.22”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [22]
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“The increase might be related to dementia manifesting at later ages, with higher physical frailty22 leading to a faster decline.”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [22]
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“People who are physically more frail are more likely to have dementia, but the relationship between pathology and symptoms in these people is comparatively weak suggesting that dementia might be from other causes.22”
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“A moderation analysis showed that the relationship between Alzheimer's disease pathology and dementia status differed according to level of frailty (adjusted for age, sex, and education) with increasing frailty weakening the relationship between Alzheimer's disease pathology and dementia (figure 10 ).22”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [22]
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Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62167-9 · Cited by 9,503
Self-citationSperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
Self-citationJack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396
A standard procedure for creating a frailty index
Searle, S. D., Mitnitski, A., Gahbauer, E. A., Gill, T. M., & Rockwood, K. (2008) · BMC Geriatrics · doi:10.1186/1471-2318-8-24 · Cited by 3,568
Self-citationAccumulation of Deficits as a Proxy Measure of Aging
Mitnitski, A. B., Mogilner, A. J., & Rockwood, K. (2001) · The Scientific World JOURNAL · doi:10.1100/tsw.2001.58 · Cited by 2,893
Self-citationAge, Neuropathology, and Dementia
Savva, G. M., Wharton, S. B., Ince, P. G., Forster, G., Matthews, F. E., & Brayne, C. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0806142 · Cited by 900
Overview and Findings from the Rush Memory and Aging Project
Bennett, D. A., Schneider, J. A., Buchman, A. S., Barnes, L. L., Boyle, P. A., & Wilson, R. S. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322663 · Cited by 849
Self-citation
Cited by
Sorted by citations
Items 101–200 of 313
The Biological Rationale for Integrating Intrinsic Capacity Into Frailty Models
Yu, Z., Lozupone, M., Chen, J., Bao, Z., Ruan, Q., & Panza, F. (2025) · Clinical Interventions in Aging · doi:10.2147/cia.s509990 · Cited by 21
Shinohara, M., Tashiro, Y., Shinohara, M., Hirokawa, J., Suzuki, K., Onishi‐Takeya, M., Mukouzono, M., Takeda, S., Saito, T., Fukumori, A., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201901028rr · Cited by 21
Rosa, G., Giannotti, C., Martella, L. A., Massa, F., Serafini, G., Pardini, M., Nobili, F. M., & Monacelli, F. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191075 · Cited by 23
Phenotypic Frailty Assessment in Mice: Development, Discoveries, and Experimental Considerations
Baumann, C. W., Kwak, D., & Thompson, L. V. (2020) · Physiology · doi:10.1152/physiol.00016.2020 · Cited by 21
Genetically predicted frailty index and risk of stroke and Alzheimer's disease
Liu, W., Zhang, L., Fang, H., Gao, Y., Liu, K., Li, S., Liu, H., Wang, X., Liu, C., Song, B., et al. (2022) · European Journal of Neurology · doi:10.1111/ene.15332 · Cited by 20
Potential association between frailty and pTau in community-dwelling older adults
Zhou, L., Shi, H., Cheng, R., Ge, M., Hu, F., Hou, L., Xia, X., Liu, X., Liu, Y., Zhao, Y., et al. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03454-0 · Cited by 20
Chen, S., Wu, H., Song, Y., Ge, H., Yan, Z., Xue, C., Qi, W., Yuan, Q., Lin, X., & Chen, J. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.115000 · Cited by 20
Neurologic and Neuroscientific Evidence in Aged COVID-19 Patients
Mainali, S., & Darsie, M. E. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.648662 · Cited by 21
Quality indicators for dementia and older people nearing the end of life: A systematic review
Yorganci, E., Sampson, E. L., Gillam, J., Aworinde, J., Léniz, J., Williamson, L. E., Cripps, R. L., Stewart, R. J., & Sleeman, K. E. (2021) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17387 · Cited by 21
Bogataj, Š., Mesarič, K. K., Pajek, M., Petrušič, T., & Pajek, J. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1032076 · Cited by 19
Siejka, T. P., Srikanth, V. K., Hubbard, R. E., Moran, C., Beare, R. J., WOOD, A. G., Collyer, T. A., Gujjari, S., Phan, T. G., & Callisaya, M. L. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac078 · Cited by 19
Chung, C., Lee, W., Chou, K., Lee, P., Peng, L., Wang, P., Lin, C., & Chen, L. (2022) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2022.104754 · Cited by 19
Research progress on the interaction between circadian clock and early vascular aging
Chen, Z., Xiong, Z., & Liu, X. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111241 · Cited by 19
Ranking the risk factors for Alzheimer’s disease; findings from the UK Biobank study
Allwright, M., Mundell, H. D., McCorkindale, A. N., Lindley, R. I., Austin, P. J., Guennewig, B., & Sutherland, G. T. (2023) · Aging Brain · doi:10.1016/j.nbas.2023.100081 · Cited by 19
Plini, E. R. G., Melnychuk, M. C., Andrews, R., Boyle, R. T., Whelan, R., Spence, J. S., Chapman, S. B., Robertson, I. H., & Dockree, P. M. (2024) · Acta Physiologica · doi:10.1111/apha.14191 · Cited by 20
Impact of Patient Mild Cognitive Impairment on Physician Decision-Making for Treatment
Blair, E. M., Zahuranec, D. B., Langa, K. M., Forman, J. H., Reale, B. K., Kollman, C. D., Giordani, B., & Levine, D. A. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200700 · Cited by 18
Lu, W., Giudici, K. V., Rolland, Y., Guyonnet, S., Li, Y., Bateman, R. J., Barreto, P. D. S., & Vellas, B. J. (2021) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2020.60 · Cited by 17
Kren, A., & Bogataj, Š. (2023) · Brain Sciences · doi:10.3390/brainsci13081228 · Cited by 17
Frailty is associated with the clinical expression of neuropsychological deficits in older adults
Canevelli, M., Wallace, L. M. K., Bruno, G., Cesari, M., Rockwood, K. J., & Ward, D. D. (2023) · European Journal of Neurology · doi:10.1111/ene.16072 · Cited by 18
Self-citationStanley, J., Howlett, S. E., Dunn, T., & Rockwood, K. J. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12242 · Cited by 17
Self-citationRuan, Q., Chen, J., Zhang, R., Zhang, W., Ruan, J., Zhang, M., Han, C., & Yu, Z. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.617610 · Cited by 17
Pre-frailty predicts cognitive decline at 2-year follow-up in persons living with HIV
Paolillo, E. W., Sun-Suslow, N., Pasipanodya, E. C., Morgan, E. E., Ellis, R. J., Jeste, D. V., & Moore, D. J. (2019) · Journal of NeuroVirology · doi:10.1007/s13365-019-00814-2 · Cited by 18
Liu, Y., Wei, K., Cao, X., Jiang, L., Gu, N., Feng, L., & Li, C. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.618833 · Cited by 16
Transcriptomic and metabolomic changes might predict frailty in SAMP8 mice
Dacomo, L., Vitola, P. L., Brunelli, L., Messa, L., Micotti, E., Artioli, L., Sinopoli, E., Cecutti, G., Leva, S., Gagliardi, S., et al. (2024) · Aging Cell · doi:10.1111/acel.14263 · Cited by 15
Rockwood, K. J., Andrew, M. K., Aubertin‐Leheudre, M., Belleville, S., Bherer, L., Bowles, S. K., Kehler, D. S., Lim, A. S. P., Middleton, L. E., Phillips, N. A., et al. (2020) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12083 · Cited by 17
Self-citationAmanzio, M., Palermo, S., Stanziano, M., D’Agata, F., Galati, A., Gentile, S., Castellano, G., Bartoli, M., Cipriani, G. E., Rubino, E., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.637796 · Cited by 15
Cezar, N. O. D. C., Aprahamian, I., Ansai, J. H., de Oliveira, M. P. B., da Silva, D. C. P., Gomes, W. D. L., Barreiros, B. A., Langelli, T. D. C. O., & de Andrade, L. P. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111390 · Cited by 15
The legacy of the 2013 G8 Dementia Summit: successes, challenges, and potential ways forward
Wallace, L. M. K., Walsh, S., & Brayne, C. (2021) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00145-8 · Cited by 15
Self-citationBellelli, G., Zucchelli, A., Benussi, A., Pinardi, E., Caratozzolo, S., Ornago, A. M., Cosseddu, M., Stella, V., Turrone, R., Massariello, F., et al. (2023) · Neurological Sciences · doi:10.1007/s10072-023-06885-8 · Cited by 15
Orkaby, A. R., Schwartz, A. W., & Callahan, K. E. (2026) · Annals of Internal Medicine · doi:10.7326/annals-25-04412 · Cited by 14
Complex mental health needs in older people living with frailty
Zhang, S., Stubbs, B., & Das‐Munshi, J. (2020) · British Journal of Hospital Medicine · doi:10.12968/hmed.2020.0476 · Cited by 14
Cognitive Function and Amyloid Marker in Frail Older Adults: The Cogfrail Cohort Study
Sourdet, S., Soriano, G., Delrieu, J., Steinmeyer, Z., Guyonnet, S., Saint‐Aubert, L., Payoux, P., Ousset, P., Ghisolfi, A., Chicoulaa, B., et al. (2021) · The Journal of Frailty & Aging · doi:10.14283/jfa.2020.57 · Cited by 15
Chen, Y., Zhang, M., Yang, C., Gao, M., Yan, Y., Deng, C., & Sun, N. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.3c05868 · Cited by 14
Pollak, C., Verghese, J., Buchman, A. S., Jin, Y., & Blumen, H. M. (2024) · The Journal of Frailty & Aging · doi:10.14283/jfa.2024.27 · Cited by 15
Wang, H., Chen, X., Zheng, M., Wu, Y., & Liu, L. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1409155 · Cited by 14
Use of Biomarkers in Ongoing Research Protocols on Alzheimer’s Disease
Canevelli, M., Remoli, G., Bacigalupo, I., Valletta, M., Blasi, M. T., Sciancalepore, F., Bruno, G., Cesari, M., & Vanacore, N. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030068 · Cited by 14
Işık, A. T., Dost, F. S., Erken, N., Öntan, M. S., Bulut, E. A., Kaya, D., Koçyiğit, S. E., Dokuzlar, Ö., & Aydın, A. E. (2022) · Current Aging Science · doi:10.2174/1573411018666220616114641 · Cited by 14
Wightman, H., Quinn, T. J., Mair, F. S., Lewsey, J., McAllister, D., & Hanlon, P. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01260-3 · Cited by 14
Tian, X., Zhu, M., Ma, Y., Wang, N., Shi, L., Liu, C., Zhang, H., Tian, N., Song, L., Tang, S., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70303 · Cited by 13
Burfeind, K. G., Zarnegarnia, Y., Tekkali, P., O’Glasser, A. Y., Quinn, J. F., & Schenning, K. J. (2022) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006185 · Cited by 13
Sun-Suslow, N., Paolillo, E. W., Morgan, E. E., Letendre, S. L., Iudicello, J. E., & Moore, D. J. (2020) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002391 · Cited by 14
Okahara, K., Ohsawa, M., Haruta‐Tsukamoto, A., Miyoshi, R., Funahashi, H., Fukutani, Y., Makita, S., Matsuo, H., & Ishida, Y. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220074 · Cited by 12
Blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study
Cho, M. H., Han, K., Lee, S. W., Jeong, S., Yoo, J. E., Kim, S., Lee, J., Chun, S., & Shin, D. W. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01211-y · Cited by 12
Zhao, X., Chen, Q., Zheng, L., Ren, L., Zhai, Y., Li, J., & He, J. (2022) · Journal of Applied Gerontology · doi:10.1177/07334648221118352 · Cited by 12
Thapa, N., Yang, J., Bae, S., Kim, G.-M., Park, H.-J., & Park, H. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20010101 · Cited by 12
Corpas, R., Solana, E., la Rosa, A. D., Sarroca, S., Griñán‐Ferré, C., Oriol, M., Corbella, E., Rodrı́guez-Farré, E., Viña, J., Pallàs, M., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00352 · Cited by 13
Zhang, W., Zhang, Q., Yang, Q., Liu, P., Sun, T., Xu, Y., Qian, X., Qiu, W., & Ma, C. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.02.022 · Cited by 12
Bohn, L., Drouin, S. M., McFall, G. P., Rolfson, D. B., Andrew, M. K., & Dixon, R. A. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-04546-1 · Cited by 11
Self-citationXu, Y., Lin, Y., Yi, L., Zhao, L., Li, X., Yu, Y., Guo, Y., Wang, Y., Jiang, H., Chen, Z., et al. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00558 · Cited by 11
Cash, M. K., Rockwood, K. J., Fisk, J. D., & Darvesh, S. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.02.025 · Cited by 11
Self-citationSato, T., Hanyu, H., Koyama, Y., Horita, H., Aoki, T., Hirao, K., Kanetaka, H., & Shimizu, S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210728 · Cited by 11
Physical frailty related to cognitive impairment and COPD exacerbation: A cross-sectional study
Tsai, C., Chang, W. P., Lin, Y., Ho, S., & Lin, Y. (2023) · Respiratory Medicine · doi:10.1016/j.rmed.2023.107129 · Cited by 11
Outcomes in Trauma Patients With Behavioral Health Disorders
Harfouche, M., Beard, J. H., Mason, L., Maher, Z., Dauer, E. D., Santora, T. A., Goldberg, A. J., & Pathak, A. S. (2019) · Journal of Surgical Research · doi:10.1016/j.jss.2019.06.061 · Cited by 11
The Problem of Integrating of Biological and Clinical Markers of Aging
Mitnitski, A., & Rockwood, K. J. (2019) · Healthy ageing and longevity · doi:10.1007/978-3-030-24970-0_23 · Cited by 11
Self-citationRole of frailty in the assessment of cognitive functioning
Canevelli, M., Cesari, M., Raganato, R., Trentin, F., Valletta, M., Salati, E., & Bruno, G. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.111122 · Cited by 11
Could there Be Frailty in the Discrepancy between Lesions and Symptoms of Alzheimer's Disease?
Canevelli, M., Bruno, G., Valletta, M., & Cesari, M. (2022) · The Journal of Frailty & Aging · doi:10.14283/jfa.2022.43 · Cited by 11
Associations of Frailty with Neuropsychiatric Symptoms of Alzheimer’s Disease: A Longitudinal Study
Chi, H., Ma, L., Wang, Z., Sheng, Z.-H., Liu, J.-Y., Mi, Y., Mi, Y., Huang, Y., Han, S.-L., Gao, P., et al. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231111 · Cited by 11
Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia prediction
Engvig, A., Kalleberg, K. T., Westlye, L. T., Leonardsen, E. H., Weiner, M. W., Aisen, P. S. S., Petersen, R. C., Jack, C. R., Jagust, W. J., Trojanowski, J. Q., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01376-w · Cited by 10
Blood biomarkers of frailty and cognition: A scoping review
Hodgins, M. L., Maxwell, S. P., Howlett, S. E., & Rockwood, K. J. (2026) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2026.01.003 · Cited by 10
Self-citationLi, J., Bur, A. M., Villwock, M. R., Shankar, S., Palmer, G., Sykes, K. J., & Villwock, J. A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210175 · Cited by 10
Engvig, A., Maglanoc, L. A., Doan, N. T., Westlye, L. T., & Initiative, A. D. N. (2022) · GeroScience · doi:10.1007/s11357-022-00669-2 · Cited by 10
Frailty Predicts Dementia and Death in Older Adults Living in Long-Term Care
Song, X., Greeley, B., Low, H., & McDermid, R. C. (2024) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2024.03.118 · Cited by 10
Chen, L.-R., Liu, C., Deng, A., Zhang, A., Zhu, M., & Xi, H. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-079139 · Cited by 10
Canevelli, M., Bacigalupo, I., Gervasi, G., Lacorte, E., Massari, M., Mayer, F., Vanacore, N., & Cesari, M. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00282 · Cited by 10
Ruan, Q., Zhang, W., Ruan, J., Chen, J., & Yu, Z. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.603974 · Cited by 10
Chen, S., Chen, T., Honda, T., Kishimoto, H., Nofuji, Y., & Narazaki, K. (2024) · GeroScience · doi:10.1007/s11357-024-01461-0 · Cited by 9
Arosio, B., Rossi, P. D., Ferri, E., Consorti, E., Ciccone, S., Lucchi, T. A., & Montano, N. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112692 · Cited by 9
Buscarnera, S., Canevelli, M., Bruno, G., Garibotto, V., Frisoni, G. B., & Ribaldi, F. (2025) · GeroScience · doi:10.1007/s11357-025-01547-3 · Cited by 10
Frailty and the brain: A narrative review of functional and pathological correlates
Sciancalepore, F., Salemme, S., Valletta, M., Blasi, M. T., Remoli, G., Zamboni, G., Vanacore, N., & Canevelli, M. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102945 · Cited by 10
Chuang, S., Wu, I., Chang, J., Tsai, Y., Cheng, C.-W., Chiu, Y., Chang, H., Lee, M. M., Hsu, C., & Hsiung, C. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-15915-y · Cited by 10
Li, Q., Zhang, S., Wang, X., Du, M., & Zhang, Q. (2022) · Geriatric Nursing · doi:10.1016/j.gerinurse.2022.06.012 · Cited by 9
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Cristofori, G., Ortego, R. A., & Gómez‐Pavón, J. (2023) · Revista de Neurología · doi:10.33588/rn.7610.2023124 · Cited by 9
Xia, X., Jönsson, L., Tazzeo, C., Qiu, C., Rizzuto, D., Laukka, E. J., Grande, G., Fratiglioni, L., & Vetrano, D. L. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae010 · Cited by 9
Gupta, U. C., & Gupta, S. C. (2019) · Current Nutrition & Food Science · doi:10.2174/1573401315666190801120306 · Cited by 9
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Metadata
- Authors
- Wallace, L. M. K., Theou, O., Godin, J., Andrew, M. K., Bennett, D. A., & Rockwood, K.
- Affiliations
- Dalhousie University (CA)
- Rush University Medical Center (US)
- Corresponding author
- Rockwood, Kenneth
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 18
- Issue
- 2
- Pages
- 177-184
- ISSN
- 1474-4422 (ISSN-L)
- PMC
- PMC11062500
- OpenAlex
- W2909144970
- Cited by
- 310
- References
- 32
- Citations by year
- 2026: 28 · 2025: 41 · 2024: 40 · 2023: 35 · 2022: 40 · 2021: 45 · 2020: 47 · 2019: 34
- FWCI
- 33.06
- Type
- journal article
- Language
- en
- Update notices
- erratum (2019-03-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institutes of Health Research (CNA-137794)
- NIH (R01AG17917)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, frailty, Alzheimer's dementia, neuropathology, neurofibrillary tangles, neuritic plaques, diffuse plaques, older adults, autopsy, Rush Memory and Aging Project, moderating effect, cognitive impairment without dementia, Alzheimer's disease biomarkers
- MeSH terms
- Frailty, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Cross-Sectional Studies, Dementia, Female, Humans, Male, Frail Elderly
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