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Cited by 3,264

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Open access
Johnson, Catherine Owens, Nguyen, Minh, Roth, Gregory A, Nichols, Emma, Alam, Tahiya, Abate, Degu, Abd-Allah, Foad, Abdelalim, Ahmed, Abraha, Haftom Niguse, Abu-Rmeileh, Niveen ME, Adebayo, Oladimeji M, Adeoye, Abiodun Moshood, Agarwal, Gina, Agrawal, Sutapa, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Alahdab, Fares, Ali, Raghib, Alvis-Guzman, Nelson, Anber, Nahla Hamed, Anjomshoa, Mina, Arabloo, Jalal, Arauz, Antonio, Ärnlöv, Johan, Arora, Amit, Awasthi, Ashish, Banach, Maciej, Barboza, Miguel A, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Basu, Sanjay, Belachew, Abate Bekele, Belayneh, Yaschilal Muche, Bennett, Derrick A., Bensenor, Isabela M, Bhattacharyya, Krittika, Biadgo, Belete, Bijani, Ali, Bikbov, Boris, Bin Sayeed, Muhammad Shahdaat, Butt, Zahid A, Cahuana-Hurtado, Lucero, Carrero, Juan J, Carvalho, Félix, Castañeda-Orjuela, Carlos A, Castro, Franz, Catalá-López, Ferrán, Chaiah, Yazan, Chiang, Peggy Pei-Chia, Choi, Jee-Young J, Christensen, Hanne, Chu, Dinh-Toi, Cortinovis, Monica, Damasceno, Albertino Antonio Moura, Dandona, Lalit, Dandona, Rakhi, Daryani, Ahmad, Davletov, Kairat, de Courten, Barbora, De la Cruz-Góngora, Vanessa, Degefa, Meaza Girma, Dharmaratne, Samath Dhamminda, Diaz, Daniel, Dubey, Manisha, Duken, Eyasu Ejeta, Edessa, Dumessa, Endres, Matthias, FARAON, EMERITO JOSE A, Farzadfar, Farshad, Fernandes, Eduarda, Fischer, Florian, Flor, Luisa Sorio, Ganji, Morsaleh, Gebre, Abadi Kahsu, Gebremichael, Teklu Gebrehiwo, Geta, Birhanu, Gezae, Kebede Embaye, Gill, Paramjit Singh, Gnedovskaya, Elena V., Gómez-Dantés, Hector, Goulart, Alessandra C, Grosso, Giuseppe, Guo, Yuming, Gupta, Rajeev, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hamidi, Samer, Hankey, Graeme J., Hassen, Hamid Yimam, Hay, Simon I., Hegazy, Mohamed I, Heidari, Behnam, Herial, Nabeel A, Hosseini, Mohammad Ali, Hostiuc, Sorin, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Jahanmehr, Nader, Javanbakht, Mehdi, Jha, Ravi Prakash, Jonas, Jost B., Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kahsay, Amaha, Kalani, Rizwan, Kalkonde, Yogeshwar, Kamil, Teshome Abegaz, Kanchan, Tanuj, Karch, André, Karimi, Narges, Karimi-Sari, Hamidreza, Kasaeian, Amir, Kassa, Tesfaye Dessale, Kazemeini, Hossein, Kefale, Adane Teshome, Khader, Yousef Saleh, Khalil, Ibrahim A., Khan, Ejaz Ahmad, Khang, Young-Ho, Khubchandani, Jagdish, Kim, Daniel, Kim, Yun Jin, Kisa, Adnan, Kivimäki, Mika, Koyanagi, Ai, Krishnamurthi, Rita K, Kumar, G Anil, Lafranconi, Alessandra, Lewington, Sarah, Li, Shanshan, Lo, Warren David, Lopez, Alan D, Lorkowski, Stefan, Lotufo, Paulo A., Mackay, Mark T, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Manafi, Navid, Mansournia, Mohammad Ali, Mehndiratta, Man Mohan, Mehta, Varshil, Mengistu, Getnet, Meretoja, Atte, Meretoja, Tuomo J, Miazgowski, Bartosz, Miazgowski, Tomasz, Miller, Ted R, Mirrakhimov, Erkin M, Mohajer, Bahram, Mohammad, Yousef, Mohammadoo-khorasani, Milad, Mohammed, Shafiu, Mohebi, Farnam, Mokdad, Ali H, Mokhayeri, Yaser, Moradi, Ghobad, Morawska, Lidia, Moreno Velásquez, Ilais, Mousavi, Seyyed Meysam, Muhammed, Oumer Sada S, Muruet, Walter, Naderi, Mehdi, Naghavi, Mohsen, Naik, Gurudatta, Nascimento, Bruno Ramos, Negoi, Ruxandra Irina, Nguyen, Cuong Tat, Nguyen, Long Hoang, Nirayo, Yirga Legesse, Norrving, Bo, Noubiap, Jean Jacques, Ofori-Asenso, Richard, Ogbo, Felix Akpojene, Olagunju, Andrew T, Olagunju, Tinuke O, Owolabi, Mayowa Ojo, Pandian, Jeyaraj Durai, Patel, Shanti, Perico, Norberto, Piradov, Michael A, Polinder, Suzanne, Postma, Maarten J, Poustchi, Hossein, Prakash, V, Qorbani, Mostafa, Rafiei, Alireza, Rahim, Fakher, Rahimi, Kazem, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Muhammad Aziz, Reis, Cesar, Remuzzi, Giuseppe, Renzaho, Andre M.N., Ricci, Stefano, Roberts, Nicholas L S, Robinson, Stephen R, Roever, Leonardo, Roshandel, Gholamreza, Sabbagh, Parisa, Safari, Hosein, Safari, Saeed, Safiri, Saeid, Sahebkar, Amirhossein, Salehi Zahabi, Saleh, Samy, Abdallah M., Santalucia, Paola, Santos, Itamar S, Santos, João Vasco, Santric Milicevic, Milena M, Sartorius, Benn, Sawant, Arundhati R, Schutte, Aletta Elisabeth, Sepanlou, Sadaf G., Shafieesabet, Azadeh, Shaikh, Masood Ali, Shams-Beyranvand, Mehran, Sheikh, Aziz, Sheth, Kevin N., Shibuya, Kenji, Shigematsu, Mika, Shin, Min-Jeong, Shiue, Ivy, Siabani, Soraya, Sobaih, Badr Hasan, Sposato, Luciano A., Sutradhar, Ipsita, Sylaja, PN, Szoeke, Cassandra E I, Te Ao, Braden James, Temsah, Mohamad-Hani, Temsah, Omar, Thrift, Amanda G, Tonelli, Marcello, Topor-Madry, Roman, Tran, Bach Xuan, Tran, Khanh Bao, Truelsen, Thomas Clement, Tsadik, Afewerki Gebremeskel, Ullah, Irfan, Uthman, Olalekan A, Vaduganathan, Muthiah, Valdez, Pascual R, Vasankari, Tommi Juhani, Vasanthan, Rajagopalan, Venketasubramanian, Narayanaswamy, Vosoughi, Kia, Vu, Giang Thu, Waheed, Yasir, Weiderpass, Elisabete, Weldegwergs, Kidu Gidey, Westerman, Ronny, Wolfe, Charles D A, Wondafrash, Dawit Zewdu, Xu, Gelin, Yadollahpour, Ali, Yamada, Tomohide, Yatsuya, Hiroshi, Yimer, Ebrahim M, Yonemoto, Naohiro, Yousefifard, Mahmoud, Yu, Chuanhua, Zaidi, Zoubida, Zamani, Mohammad, Zarghi, Afshin, Zhang, Yunquan, Zodpey, Sanjay, Feigin, Valery L., Vos, Theo, Murray, Christopher J L·2019·The Lancet Neurology
DOI 10.1016/s1474-4422(19)30034-1
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Abstract

BACKGROUND: Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide information to health systems and policy makers on more than 300 causes of disease and injury, including stroke. The results presented here are the estimates of burden due to overall stroke and ischaemic and haemorrhagic stroke from GBD 2016. METHODS: We report estimates and corresponding uncertainty intervals (UIs), from 1990 to 2016, for incidence, prevalence, deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs). DALYs were generated by summing YLLs and YLDs. Cause-specific mortality was estimated using an ensemble modelling process with vital registration and verbal autopsy data as inputs. Non-fatal estimates were generated using Bayesian meta-regression incorporating data from registries, scientific literature, administrative records, and surveys. The Socio-demographic Index (SDI), a summary indicator generated using educational attainment, lagged distributed income, and total fertility rate, was used to group countries into quintiles. FINDINGS: In 2016, there were 5·5 million (95% UI 5·3 to 5·7) deaths and 116·4 million (111·4 to 121·4) DALYs due to stroke. The global age-standardised mortality rate decreased by 36·2% (-39·3 to -33·6) from 1990 to 2016, with decreases in all SDI quintiles. Over the same period, the global age-standardised DALY rate declined by 34·2% (-37·2 to -31·5), also with decreases in all SDI quintiles. There were 13·7 million (12·7 to 14·7) new stroke cases in 2016. Global age-standardised incidence declined by 8·1% (-10·7 to -5·5) from 1990 to 2016 and decreased in all SDI quintiles except the middle SDI group. There were 80·1 million (74·1 to 86·3) prevalent cases of stroke globally in 2016; 41·1 million (38·0 to 44·3) in women and 39·0 million (36·1 to 42·1) in men. INTERPRETATION: Although age-standardised mortality rates have decreased sharply from 1990 to 2016, the decrease in age-standardised incidence has been less steep, indicating that the burden of stroke is likely to remain high. Planned updates to future GBD iterations include generating separate estimates for subarachnoid haemorrhage and intracerebral haemorrhage, generating estimates of transient ischaemic attack, and including atrial fibrillation as a risk factor. FUNDING: Bill & Melinda Gates Foundation.

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Research works printed but not linked: 2

  1. Krishnamurthi R, Bhattaacharjee R, Parmar P. Effectiveness of the stroke riskometer app for primary stroke prevention: a pilot RCT. International Stroke Conference; Los Angeles; Jan 23–26, 2018. 85.
  2. Smith, 2016, Brief history of endovascular acute ischemic stroke treatment, Stroke, 47, e23, 10.1161/STROKEAHA.115.010863 · doi:10.1161/strokeaha.115.010863

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Authors
Johnson, C. O., Nguyen, M., Roth, G. A., Nichols, E., Alam, T., Abate, D., Abd-Allah, F., Abdelalim, A., Abraha, H. N., Abu-Rmeileh, N. M., Adebayo, O. M., Adeoye, A. M., Agarwal, G., Agrawal, S., Aichour, A. N., Aichour, I., Aichour, M. T. E., Alahdab, F., Ali, R., Alvis-Guzman, N., Anber, N. H., Anjomshoa, M., Arabloo, J., Arauz, A., Ärnlöv, J., Arora, A., Awasthi, A., Banach, M., Barboza, M. A., Barker-Collo, S. L., Bärnighausen, T. W., Basu, S., Belachew, A. B., Belayneh, Y. M., Bennett, D. A., Bensenor, I. M., Bhattacharyya, K., Biadgo, B., Bijani, A., Bikbov, B., Bin Sayeed, M. S., Butt, Z. A., Cahuana-Hurtado, L., Carrero, J. J., Carvalho, F., Castañeda-Orjuela, C. A., Castro, F., Catalá-López, F., Chaiah, Y., Chiang, P. P.-C., Choi, J.-Y. J., Christensen, H., Chu, D.-T., Cortinovis, M., Damasceno, A. A. M., Dandona, L., Dandona, R., Daryani, A., Davletov, K., de Courten, B., De la Cruz-Góngora, V., Degefa, M. G., Dharmaratne, S. D., Diaz, D., Dubey, M., Duken, E. E., Edessa, D., Endres, M., FARAON, E. J. A., Farzadfar, F., Fernandes, E., Fischer, F., Flor, L. S., Ganji, M., Gebre, A. K., Gebremichael, T. G., Geta, B., Gezae, K. E., Gill, P. S., Gnedovskaya, E. V., Gómez-Dantés, H., Goulart, A. C., Grosso, G., Guo, Y., Gupta, R., Haj-Mirzaian, A., Haj-Mirzaian, A., Hamidi, S., Hankey, G. J., Hassen, H. Y., Hay, S. I., Hegazy, M. I., Heidari, B., Herial, N. A., Hosseini, M. A., Hostiuc, S., Irvani, S. S. N., Islam, S. M. S., Jahanmehr, N., Javanbakht, M., Jha, R. P., Jonas, J. B., Jozwiak, J. J., Jürisson, M., Kahsay, A., Kalani, R., Kalkonde, Y., Kamil, T. A., Kanchan, T., Karch, A., Karimi, N., Karimi-Sari, H., Kasaeian, A., Kassa, T. D., Kazemeini, H., Kefale, A. T., Khader, Y. S., Khalil, I. A., Khan, E. A., Khang, Y.-H., Khubchandani, J., Kim, D., Kim, Y. J., Kisa, A., Kivimäki, M., Koyanagi, A., Krishnamurthi, R. K., Kumar, G. A., Lafranconi, A., Lewington, S., Li, S., Lo, W. D., Lopez, A. D., Lorkowski, S., Lotufo, P. A., Mackay, M. T., Majdan, M., Majdzadeh, R., Majeed, A., Malekzadeh, R., Manafi, N., Mansournia, M. A., Mehndiratta, M. M., Mehta, V., Mengistu, G., Meretoja, A., Meretoja, T. J., Miazgowski, B., Miazgowski, T., Miller, T. R., Mirrakhimov, E. M., Mohajer, B., Mohammad, Y., Mohammadoo-khorasani, M., Mohammed, S., Mohebi, F., Mokdad, A. H., Mokhayeri, Y., Moradi, G., Morawska, L., Moreno Velásquez, I., Mousavi, S. M., Muhammed, O. S. S., Muruet, W., Naderi, M., Naghavi, M., Naik, G., Nascimento, B. R., Negoi, R. I., Nguyen, C. T., Nguyen, L. H., Nirayo, Y. L., Norrving, B., Noubiap, J. J., Ofori-Asenso, R., Ogbo, F. A., Olagunju, A. T., Olagunju, T. O., Owolabi, M. O., Pandian, J. D., Patel, S., Perico, N., Piradov, M. A., Polinder, S., Postma, M. J., Poustchi, H., Prakash, V, Qorbani, M., Rafiei, A., Rahim, F., Rahimi, K., Rahimi-Movaghar, V., Rahman, M., Rahman, M. A., Reis, C., Remuzzi, G., Renzaho, A. M. N., Ricci, S., Roberts, N. L. S., Robinson, S. R., Roever, L., Roshandel, G., Sabbagh, P., Safari, H., Safari, S., Safiri, S., Sahebkar, A., Salehi Zahabi, S., Samy, A. M., Santalucia, P., Santos, I. S., Santos, J. V., Santric Milicevic, M. M., Sartorius, B., Sawant, A. R., Schutte, A. E., Sepanlou, S. G., Shafieesabet, A., Shaikh, M. A., Shams-Beyranvand, M., Sheikh, A., Sheth, K. N., Shibuya, K., Shigematsu, M., Shin, M.-J., Shiue, I., Siabani, S., Sobaih, B. H., Sposato, L. A., Sutradhar, I., Sylaja, P., Szoeke, C. E. I., Te Ao, B. J., Temsah, M.-H., Temsah, O., Thrift, A. G., Tonelli, M., Topor-Madry, R., Tran, B. X., Tran, K. B., Truelsen, T. C., Tsadik, A. G., Ullah, I., Uthman, O. A., Vaduganathan, M., Valdez, P. R., Vasankari, T. J., Vasanthan, R., Venketasubramanian, N., Vosoughi, K., Vu, G. T., Waheed, Y., Weiderpass, E., Weldegwergs, K. G., Westerman, R., Wolfe, C. D. A., Wondafrash, D. Z., Xu, G., Yadollahpour, A., Yamada, T., Yatsuya, H., Yimer, E. M., Yonemoto, N., Yousefifard, M., Yu, C., Zaidi, Z., Zamani, M., Zarghi, A., Zhang, Y., Zodpey, S., Feigin, V. L., Vos, T., & Murray, C. J. L.
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2019-05
Volume
18
Issue
5
Pages
439-458
ISSN
1474-4422 (ISSN-L)
DOI
10.1016/s1474-4422(19)30034-1
OpenAlex
W2921112006
Cited by
3,264
References
41
FWCI
324.40
Type
journal article
Language
en
Open access
hybrid
Licence
Funders
  • Pfizer
  • Commonwealth Scientific and Industrial Research Organisation
  • Astellas Pharma US
  • Alzheimer's Australia
  • AstraZeneca
  • GlaxoSmithKline
  • Bayer HealthCare
  • National Health and Medical Research Council (1032350, 1062133, 547600)
  • Bristol-Myers Squibb
  • Brain Foundation
  • Sanofi
  • Bundesministerium für Bildung und Forschung
  • AbbVie
  • GE Healthcare
  • Deutsche Forschungsgemeinschaft
  • Fondation Leducq
  • Merck
  • Ministry of Education, Culture, Sports, Science and Technology
  • Novartis
  • University of Melbourne
  • Judith Jane Mason and Harold Stannett Williams Memorial Foundation
  • Shepherd Foundation
  • Ramaciotti Foundations
  • NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
  • Covidien
  • Daiichi-Sankyo
  • Meso Scale Diagnostics
  • Ministry of Health, Labour and Welfare
  • VicHealth
  • Oxford Martin School, University of Oxford
  • Research Councils UK
  • European Commission
  • Alzheimer's Association (NIA320312)
  • Boehringer Ingelheim
  • Bayer Fund
  • Corona-Stiftung
  • Economic and Social Research Council

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CoChat. (2026). Citation check: Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. https://app.cochat.ai/papers/10.1016/s1474-4422(19)30034-1
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Johnson, C. O., Nguyen, M., Roth, G. A., Nichols, E., Alam, T., Abate, D., Abd-Allah, F., Abdelalim, A., Abraha, H. N., Abu-Rmeileh, N. M., Adebayo, O. M., Adeoye, A. M., Agarwal, G., Agrawal, S., Aichour, A. N., Aichour, I., Aichour, M. T. E., Alahdab, F., Ali, R., . . . Murray, C. J. L. (2019). Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology. https://doi.org/10.1016/s1474-4422(19)30034-1

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