The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Migraine and the trigeminovascular system—40 years and counting
Open accessAbstract
The underlying causes of migraine headache remained enigmatic for most of the 20th century. In 1979, The Lancet published a novel hypothesis proposing an integral role for the neuropeptide-containing trigeminal nerve. This hypothesis led to a transformation in the migraine field and understanding of key concepts surrounding migraine, including the role of neuropeptides and their release from meningeal trigeminal nerve endings in the mechanism of migraine, blockade of neuropeptide release by anti-migraine drugs, and activation and sensitisation of trigeminal afferents by meningeal inflammatory stimuli and upstream role of intense brain activity. The study of neuropeptides provided the first evidence that antisera directed against calcitonin gene-related peptide (CGRP) and substance P could neutralise their actions. Successful therapeutic strategies using humanised monoclonal antibodies directed against CGRP and its receptor followed from these findings. Nowadays, 40 years after the initial proposal, the trigeminovascular system is widely accepted as having a fundamental role in this highly complex neurological disorder and provides a road map for future migraine therapies.
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Cites
Interplay between Cortical Spreading Depolarization and Seizures
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Self-citationBrain stem activation in spontaneous human migraine attacks
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Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model
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Self-citationCalcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine
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Cgrp May Play A Causative Role in Migraine
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Self-citationDiagnosis and management of migraine in ten steps
Eigenbrodt, A. K., Ashina, H., Khan, S., Diener, H.-C., Mitsikostas, D. D., Sinclair, A. J., Pozo-Rosich, P., Martelletti, P., Ducros, A., Lantéri-Minet, M., et al. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00509-5 · Cited by 594
Self-citationCGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
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Applying a biopsychosocial model to migraine: rationale and clinical implications
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Metadata
- Authors
- Ashina, M., Hansen, J. M., Do, T. P., Melo-Carrillo, A., Burstein, R., & Moskowitz, M. A.
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 18
- Issue
- 8
- Pages
- 795-804
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2947345259
- Cited by
- 606
- References
- 81
- FWCI
- 31.63
- Type
- journal article
- Language
- en
- Open access
- green
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- Ashina, M., Hansen, J. M., Do, T. P., Melo-Carrillo, A., Burstein, R., & Moskowitz, M. A. (2019). Migraine and the trigeminovascular system—40 years and counting. The Lancet Neurology. https://doi.org/10.1016/s1474-4422(19)30185-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
