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Cgrp May Play A Causative Role in Migraine
Abstract
Calcitonin gene-related peptide (CGRP) has been detected in increased amounts in external jugular venous blood during migraine attacks. However, it is unknown whether this is secondary to migraine or whether CGRP may cause headache. In a double-blind crossover study, the effect of human αCGRP (2 μg/min) or placebo infused intravenously for 20 min was studied in 12 patients suffering from migraine without aura. Headache intensity was scored on a scale from 0 to 10. Two patients were excluded due to severe hypotension and one because she had an infection. In the first hour median peak headache score was 1.0 in the hαCGRP group vs. 0 in the placebo group ( P < 0.01). During the following 11 h all patients experienced headaches after hαCGRP vs. one patient after placebo ( P = 0.0004). The median maximal headache score was 4 after CGRP and 0 after placebo ( P = 0.006). In three patients after hαCGRP, but in no patients after placebo, the delayed headache fulfilled the IHS criteria for migraine without aura. As intravenous administration of hαCGRP causes headache and migraine in migraineurs, our study suggests that the increase in CGRP observed during spontaneous migraine attacks may play a causative role.
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Cited by
Pathophysiology of migraine: a disorder of sensory processing
Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00034.2015 · Cited by 1,998
Calcitonin Gene-Related Peptide: Physiology and Pathophysiology
Russell, F. A., King, R., Smillie, S.-J., Kodji, X., & Brain, S. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00034.2013 · Cited by 1,258
Vascular Actions of Calcitonin Gene-Related Peptide and Adrenomedullin
Brain, S. D., & Grant, A. D. (2004) · Physiological Reviews · doi:10.1152/physrev.00037.2003 · Cited by 765
Tepper, S., Ashina, M., Reuter, U., Brandes, J. L., Doležil, D., Silberstein, S., Winner, P., Leonardi, D., Mikol, D., & Lenz, R. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30083-2 · Cited by 722
Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine
Cernuda-Morollón, E., Larrosa, D., Ramón, C., Vega, J., Martínez-Camblor, P., & Pascual, J. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a6cb72 · Cited by 468
Metadata
- Authors
- Lassen, L., Haderslev, P., Jacobsen, V., Iversen, H., Sperling, B., & Olesen, J.
- Venue
- Cephalalgia
- Publisher
- SAGE Publications
- Published
- 2002-02
- Volume
- 22
- Issue
- 1
- Pages
- 54-61
- ISSN
- 0333-1024 (ISSN-L)
- 1468-2982
- OpenAlex
- W2162942726
- Cited by
- 1,027
- References
- 0
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lassen, L., Haderslev, P., Jacobsen, V., Iversen, H., Sperling, B., & Olesen, J. (2002). Cgrp May Play A Causative Role in Migraine. Cephalalgia. https://doi.org/10.1046/j.1468-2982.2002.00310.x
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