The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation
Abstract
Intracerebral haemorrhage is inadequately controlled by current treatments, requiring new solutions to improve the prognosis. Following the primary injury, a proinflammatory cascade in the perihaematomal region, composed of activated resident microglia and astrocytes and infiltrated leucocytes, propagates neural cell death. The protracted nature of neuroinflammation in intracerebral haemorrhage provides a window of opportunity for therapies to subdue the undesired consequences. In animal models and early clinical trials in intracerebral haemorrhage, several drugs have reduced detrimental neuroinflammation without substantial compromise of the beneficial reparative aspects of an inflammatory response. Potential strategies include controlling excessive harmful neuroinflammation with minocycline, sphingosine-1-phosphate receptor modulators, and statins after a brain haemorrhage. The quick initiation of these drugs, particularly in high systemic doses, could be key to counteracting the evolving secondary injury in people with intracerebral haemorrhage and provides a promising way in which the poor prognosis of intracerebral haemorrhage might one day be counteracted.
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Cites
Neurotoxic reactive astrocytes are induced by activated microglia
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
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Minocycline selectively inhibits M1 polarization of microglia
Kobayashi, K., Imagama, S., Ohgomori, T., Hirano, K., Uchimura, K., Sakamoto, K., Hirakawa, A., Takeuchi, H., Suzumura, A., Ishiguro, N., et al. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.54 · Cited by 742
Role of matrix metalloproteinases in delayed cortical responses after stroke
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Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
Gordon, P. H., Moore, D. H., Miller, R. G., Florence, J. M., Verheijde, J. L., Doorish, C., Hilton, J. F., Spitalny, G. M., MacArthur, R. B., Mitsumoto, H., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70270-3 · Cited by 649
Metalloproteinases: Mediators of Pathology and Regeneration in the CNS
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Self-citationThe Promise of Minocycline in Neurology
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Neuroinflammation after Intracerebral Hemorrhage and Potential Therapeutic Targets
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Minocycline treatment in acute stroke: An open-label, evaluator-blinded study
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Increased Brain Expression of Matrix Metalloproteinase-9 After Ischemic and Hemorrhagic Human Stroke
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Cited by
Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke
Alsbrook, D. L., Di Napoli, M., Bhatia, K., Biller, J., Andalib, S., Hinduja, A., Rodrigues, R., Rodriguez, M., Sabbagh, S. Y., Selim, M., et al. (2023) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-023-01282-2 · Cited by 521
Metadata
- Authors
- Xue, M., & Yong, V. W.
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 19
- Issue
- 12
- Pages
- 1023-1032
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W3098640872
- Cited by
- 323
- References
- 73
- FWCI
- 12.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xue, M., & Yong, V. W. (2020). Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation. The Lancet Neurology. https://doi.org/10.1016/s1474-4422(20)30364-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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