The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease
Open accessAbstract
Summary Sporadic Creutzfeldt-Jakob disease (sCJD) is a fatal and potentially transmissible neurodegenerative disease caused by misfolded prion proteins (PrPSc). To date, effective therapeutics are not available and accurate diagnosis can be challenging. Clinical diagnostic criteria employ a combination of characteristic neuropsychiatric symptoms, cerebrospinal fluid (CSF) proteins 14–3-3, MRI, and EEG. Supportive biomarkers such as high CSF total Tau may aid the diagnostic process. Discordant results of studies however, have led to controversies about the clinical value of some established surrogate biomarkers. The recent development and clinical application of disease-specific protein aggregation and amplification assays such as Real-time Quaking Induced Conversion (RT-QuIC) have constituted major breakthroughs for the confident pre-mortem diagnosis of sCJD. Updated criteria for the diagnosis of sCJD including RT-QuIC will improve early clinical confirmation, surveillance, assessment of PrPSc seeding activity in different tissues, and trial monitoring. Moreover, emerging blood-based, prognostic, and potentially pre-symptomatic biomarker candidates are under current investigation.
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Cites
Tau in physiology and pathology
Wang, Y., & Mandelkow, E. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.1 · Cited by 2,251
Statistics Notes: Diagnostic tests 2: predictive values
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Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding
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Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease
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Self-citationNeurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss
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Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion
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Self-citation14-3-3 proteins in the nervous system
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Rapid End-Point Quantitation of Prion Seeding Activity with Sensitivity Comparable to Bioassays
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Diffusion-weighted MRI hyperintensity patterns differentiate CJD from other rapid dementias
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Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission
Livingston, G., Huntley, J., Liu, K. Y., Costafreda, S. G., Selbæk, G., Alladi, S., Ames, D., Banerjee, S., Burns, A., Brayne, C., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01296-0 · Cited by 3,860
Autoimmune Encephalitis Misdiagnosis in Adults
Flanagan, E. P., Geschwind, M. D., Lopez-Chiriboga, A. S., Blackburn, K. M., Turaga, S., Binks, S., Zitser, J., Gelfand, J. M., Day, G. S., Dunham, S. R., et al. (2023) · JAMA Neurology · doi:10.1001/jamaneurol.2022.4251 · Cited by 303
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NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression
Mengel, D., Mok, T. H., Nihat, A., Liu, W., Rissman, R. A., Galasko, D., Zetterberg, H., Mead, S., Collinge, J., & Walsh, D. M. (2021) · Cells · doi:10.3390/cells10123514 · Cited by 12
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Metadata
- Authors
- Hermann, P., Appleby, B., Brandel, J.-P., Caughey, B., Collins, S., Geschwind, M. D., Green, A., Haïk, S., Kovacs, G. G., Ladogana, A., Llorens, F., Mead, S., Nishida, N., Pal, S., Parchi, P., Pocchiari, M., Satoh, K., Zanusso, G., & Zerr, I.
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 20
- Issue
- 3
- Pages
- 235-246
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W3132607516
- Cited by
- 361
- References
- 103
- FWCI
- 16.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Hermann, P., Appleby, B., Brandel, J.-P., Caughey, B., Collins, S., Geschwind, M. D., Green, A., Haïk, S., Kovacs, G. G., Ladogana, A., Llorens, F., Mead, S., Nishida, N., Pal, S., Parchi, P., Pocchiari, M., Satoh, K., Zanusso, G., & Zerr, I. (2021). Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease. The Lancet Neurology. https://doi.org/10.1016/s1474-4422(20)30477-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
