Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

Petzold, Axel

doi:10.1016/j.jns.2005.03.015

Cited by 688Skin and Cellular Biology ResearchHereditary Neurological DisordersMultiple Sclerosis Research Studies

Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

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Petzold, Axel·2005·Journal of the Neurological Sciences

DOI 10.1016/j.jns.2005.03.015

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Abstract

This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising anti-neurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the present symposium on multiple sclerosis, the current literature on body fluid levels of neurofilaments in demyelinating disease is summarised.

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NfL forms part of the axonal cytoskeleton and is found mainly in large myelinated axons.
“NfL is a component of the axonal cytoskeleton and is primarily expressed in large-caliber myelinated axons11,12.”
From Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease (2019) · cites this paper as [11]
In mice and in several neurological conditions, including proteopathic neurodegenerative diseases, fluid NfL changes have been associated with brain damage and atrophy.
“Changes of NfL in bodily fluids have been linked to brain damage and brain atrophy in mouse models and multiple neurological disorders including proteopathic neurodegenerative diseases11,13–16.”
From Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease (2019) · cites this paper as [11]

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Authors: Petzold, A.
Affiliations: UCL Queen Square Institute of Neurology (GB)
Corresponding author: Petzold, Axel
ORCID: Petzold, Axel
Venue: Journal of the Neurological Sciences
Publisher: Elsevier BV
Published: 2005-06
Volume: 233
Issue: 1-2
Pages: 183-198
ISSN: 0022-510X (ISSN-L)
DOI: 10.1016/j.jns.2005.03.015
OpenAlex: W2133652987
Cited by: 688
References: 135
Citations by year: 2026: 26 · 2025: 44 · 2024: 40 · 2023: 49 · 2022: 46 · 2021: 65 · 2020: 42 · 2019: 54 · 2018: 38 · 2017: 27 · 2016: 24 · 2015: 23 · 2014: 38 · 2013: 27 · 2012: 24
FWCI: 1.17
Type: journal article
Language: en
Open access: green
discovery.ucl.ac.uk
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the Neurological Sciences (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Keywords: neurofilaments, axonal injury, axonal degeneration, surrogate markers, neurofilament assembly, multiple sclerosis, demyelinating disease, neurodegeneration
MeSH terms: Animals, Axons, Enzyme-Linked Immunosorbent Assay, Glycosylation, Humans, Immunohistochemistry, Models, Biological, Nerve Degeneration, Phosphorylation, Blotting, Western, Biomarkers, Neurofilament Proteins, Protein Isoforms

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Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

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