The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Tadalafil: a novel treatment for erectile dysfunction
Abstract
Tadalafil, a potent, selective and reversible inhibitor of phosphodiesterase type 5 that is under review as an oral therapy for erectile dysfunction, has a time to maximum concentration of 2 h and a half-life of 17·5 h. Systemic tadalafil exposure was not clinically significantly altered by age or diabetes. Food did not alter the rate and extent of absorption of tadalafil, and no restrictions regarding food or alcohol intake were imposed on patients in tadalafil clinical trials. Furthermore, the time of dosing had no significant effect on the systemic distribution of tadalafil. Integrated analyses of data from five phase III trials demonstrated that tadalafil at doses from 5 mg to 20 mg significantly improved erectile function (vs placebo) by all efficacy measures. Tadalafil was safe and well tolerated in the phase III studies, with headache and dyspepsia being the most frequent adverse events. Additionally, in a separate study of patients with erectile dysfunction and diabetes, tadalafil 10 mg and 20 mg significantly improved all efficacy measures as compared with placebo.
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Self-citationSEXUAL FUNCTION IN MEN WITH DIABETES TYPE 2: ASSOCIATION WITH GLYCEMIC CONTROL
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On-demand IC351 (Cialis™) enhances erectile function in patients with erectile dysfunction
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Cited by
Update on Phosphodiesterase (PDE) Isoenzymes as Pharmacologic Targets in Urology: Present and Future
Ückert, S., Hedlund, P., Andersson, K., Truß, M. C., Udo Jonas, A., & Stief, C. G. (2006) · European Urology · doi:10.1016/j.eururo.2006.05.025 · Cited by 100
Effect of tadalafil on cytochrome P450 3A4?mediated clearance: Studies in vitro and in vivo
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A simple and sensitive HPLC fluorescence method for determination of tadalafil in mouse plasma
Farthing, C. A., Farthing, D. E., Koka, S., Larus, T. L., Fakhry, I., Xi, L., Kukreja, R. C., Sica, D. A., & Gehr, T. W. B. (2010) · Journal of Chromatography B · doi:10.1016/j.jchromb.2010.07.022 · Cited by 60
Cheng, C., & Chou, C. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.06.017 · Cited by 49
Ahmed, M. M., Fatima, F., Kalam, M. A., Alshamsan, A., Soliman, G. A., Shaikh, A. A., Alshahrani, S. M., Aldawsari, M. F., Bhatia, S., & Anwer, M. K. (2020) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2020.11.007 · Cited by 37
Metadata
- Authors
- GIULIANO, F.
- Affiliations
- Bicêtre Hospital (FR)
- Corresponding author
- GIULIANO, F
- Venue
- European Heart Journal Supplements
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-12
- Volume
- 4
- Pages
- H24-H31
- ISSN
- 1520-765X (ISSN-L)
- OpenAlex
- W2097718744
- Semantic Scholar
- 96594c380288d18874e49e84e1b84e445695af75
- Cited by
- 21
- References
- 22
- Citations by year
- 2024: 1 · 2022: 2 · 2020: 2 · 2014: 1
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal Supplements (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Keywords
- tadalafil, erectile dysfunction, phosphodiesterase-5 inhibitors, oral therapy, pharmacokinetics, timing of drug administration, diabetes mellitus, erectile function, drug safety, adverse events
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- CoChat. (2026). Citation check: Tadalafil: a novel treatment for erectile dysfunction. https://app.cochat.ai/papers/10.1016/s1520-765x(02)90049-0
- The paper
- GIULIANO, F. (2002). Tadalafil: a novel treatment for erectile dysfunction. European Heart Journal Supplements. https://doi.org/10.1016/s1520-765x(02)90049-0
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
