The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Tadalafil: a novel treatment for erectile dysfunction
Abstract
Tadalafil, a potent, selective and reversible inhibitor of phosphodiesterase type 5 that is under review as an oral therapy for erectile dysfunction, has a time to maximum concentration of 2 h and a half-life of 17·5 h. Systemic tadalafil exposure was not clinically significantly altered by age or diabetes. Food did not alter the rate and extent of absorption of tadalafil, and no restrictions regarding food or alcohol intake were imposed on patients in tadalafil clinical trials. Furthermore, the time of dosing had no significant effect on the systemic distribution of tadalafil. Integrated analyses of data from five phase III trials demonstrated that tadalafil at doses from 5 mg to 20 mg significantly improved erectile function (vs placebo) by all efficacy measures. Tadalafil was safe and well tolerated in the phase III studies, with headache and dyspepsia being the most frequent adverse events. Additionally, in a separate study of patients with erectile dysfunction and diabetes, tadalafil 10 mg and 20 mg significantly improved all efficacy measures as compared with placebo.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Citations
Cites
Rosen, R. C., Riley, A., Wagner, G., Osterloh, I. H., Kirkpatrick, J., & Mishra, A. (1997) · Urology · doi:10.1016/s0090-4295(97)00238-0 · Cited by 5,849
Andersson, K. E., & Wagner, G. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.1.191 · Cited by 1,119
Boolell, M., Mj, A., Sa, B., Gepi-Attee, S., Muirhead, G. J., Naylor, A. M., Ih, O., & Gingell, C. (1996) · PubMed · Cited by 1,067
(1999) · doi:10.1016/s0090-4295(99)00099-0 · Cited by 1,051
Rajfer, J., Aronson, W. J., Bush, P. A., Dorey, F. J., & Ignarro, L. J. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201093260203 · Cited by 1,006
Ignarro, L. J., Bush, P. A., Buga, G. M., Wood, K. S., Fukuto, J. M., & Rajfer, J. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)92168-y · Cited by 832
Brock, G. B., McMahon, C. G., Chen, K. K., Costigan, T., Shen, W., Watkins, V., Anglin, G., & Whitaker, S. (2002) · Journal of Urology · doi:10.1016/s0022-5347(05)64442-4 · Cited by 421
Porst, H., Rosen, R., Padma-Nathan, H., Goldstein, I., Giuliano, F., Ulbrich, E., & T Bandel and the Vardenafil Study Group (2001) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900713 · Cited by 325
Self-citationSEXUAL FUNCTION IN MEN WITH DIABETES TYPE 2: ASSOCIATION WITH GLYCEMIC CONTROL
ROMEO, J. H., SEFTEL, A. D., MADHUN, Z. T., & ARON, D. C. (2000) · Journal of Urology · doi:10.1016/s0022-5347(05)67805-6 · Cited by 274
On-demand IC351 (Cialis™) enhances erectile function in patients with erectile dysfunction
Padma-Nathan, H., McMurray, J. E., Pullman, W. T., Whitaker, J. S., Saoud, J., Ferguson, K., Rosen, R., & for the IC351 On-Demand Dosing Study Group (2001) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900631 · Cited by 210
Langtry, H. D., & Markham, A. (1999) · Drugs · doi:10.2165/00003495-199957060-00015 · Cited by 200
Effects of Tadalafil on Erectile Dysfunction in Men With Diabetes
Sáenz de Tejada, I., Anglin, G., Knight, J. R., & Emmick, J. T. (2002) · Diabetes Care · doi:10.2337/diacare.25.12.2159 · Cited by 195
Nitric oxide and cGMP: mediators of pelvic nerve-stimulated erection in dogs
Trigo-Rocha, F. E., Aronson, W. J., Hohenfellner, M., Ignarro, L. J., Rajfer, J., & Lue, T. F. (1993) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1993.264.2.h419 · Cited by 116
Oral drug therapy for erectile dysfunction
Padma-Nathan, H., & Giuliano, F. (2001) · Urologic Clinics of North America · doi:10.1016/s0094-0143(05)70141-5 · Cited by 77
Self-citationWilt, T. J., MacDonald, R. H., & Nelson, D. B. (2002) · The Journal of Urology · doi:10.1016/s0022-5347(05)65407-9 · Cited by 74
Indications and early results of sildenafil (Viagra) in erectile dysfunction
Virag, R. (1999) · Urology · doi:10.1016/s0090-4295(99)00310-6 · Cited by 53
Rotella, D. P., Sun, Z., Zhu, Y., Krupinski, J., Pongrac, R., Seliger, L. S., Normandin, D. E., & Macor, J. E. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm000081+ · Cited by 45
Erectogenic effect of the selective phosphodiesterase type 5 inhibitor, DA-8159
Oh, T. Y., Kang, K. K., Ahn, B. O., Yoo, M., & Kim, W. B. (2000) · Archives of Pharmacal Research · doi:10.1007/bf02976575 · Cited by 42
Takagi, M., Mochida, H., Noto, T., Yano, K., Inoue, H., Ikeo, T., & Kikkawa, K. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00907-9 · Cited by 30
Burls, A., Gold, L. H., & Clark, W. K. (2001) · Europe PMC (PubMed Central) · Cited by 28
Sildenafil: Efficacy and Safety in Daily Clinical Experience
Palumbo, F., Bettocchi, C., Selvaggi, F. P., PRYOR, J. P., & Ralph, D. J. (2001) · European Urology · doi:10.1159/000049769 · Cited by 28
Noto, T., Inoue, H., Ikeo, T., & Kikkawa, K. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39147-5 · Cited by 22
Cited by
Update on Phosphodiesterase (PDE) Isoenzymes as Pharmacologic Targets in Urology: Present and Future
Ückert, S., Hedlund, P., Andersson, K., Truß, M. C., Udo Jonas, A., & Stief, C. G. (2006) · European Urology · doi:10.1016/j.eururo.2006.05.025 · Cited by 100
Effect of tadalafil on cytochrome P450 3A4?mediated clearance: Studies in vitro and in vivo
Ring, B. J., Patterson, B. E., MITCHELL, M., VandenBranden, M. R., Gillespie, J. S., Bedding, A. W., Jewell, H., PAYNE, C., Forgue, S. T., Eckstein, J. A., et al. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2004.09.006 · Cited by 90
A simple and sensitive HPLC fluorescence method for determination of tadalafil in mouse plasma
Farthing, C. A., Farthing, D. E., Koka, S., Larus, T. L., Fakhry, I., Xi, L., Kukreja, R. C., Sica, D. A., & Gehr, T. W. B. (2010) · Journal of Chromatography B · doi:10.1016/j.jchromb.2010.07.022 · Cited by 60
Cheng, C., & Chou, C. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.06.017 · Cited by 49
Ahmed, M. M., Fatima, F., Kalam, M. A., Alshamsan, A., Soliman, G. A., Shaikh, A. A., Alshahrani, S. M., Aldawsari, M. F., Bhatia, S., & Anwer, M. K. (2020) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2020.11.007 · Cited by 37
Metadata
- Authors
- GIULIANO, F.
- Affiliations
- Bicêtre Hospital (FR)
- Corresponding author
- GIULIANO, F
- Venue
- European Heart Journal Supplements
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-12
- Volume
- 4
- Pages
- H24-H31
- ISSN
- 1520-765X (ISSN-L)
- OpenAlex
- W2097718744
- Semantic Scholar
- 96594c380288d18874e49e84e1b84e445695af75
- Cited by
- 21
- References
- 22
- Citations by year
- 2024: 1 · 2022: 2 · 2020: 2 · 2014: 1
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal Supplements (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Keywords
- tadalafil, erectile dysfunction, phosphodiesterase-5 inhibitors, oral therapy, pharmacokinetics, timing of drug administration, diabetes mellitus, erectile function, drug safety, adverse events
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
