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Endometriosis is associated with central sensitization: a psychophysical controlled study
Open accessAbstract
Endometriosis is a pain syndrome representing a major cause of pelvic pain in women of reproductive age. The aim of this study was to test the hypothesis that persistent nociceptive input from endometriotic tissues leads to central sensitization manifested by somatic hyperalgesia and increased referred pain areas to experimental saline-induced muscle pain in patients with endometriosis, compared to healthy control subjects. Ten women with laparoscopically confirmed endometriosis and 10 healthy, age-matched women participated in the study. Hypertonic saline (0.5 mL, 5.8%) was injected intramuscularly, in random succession, into 1 site of menstrual pain referral (the multifidus muscle at the low back) and into 1 non-pain control site (first dorsal interosseous muscle [FDI] of the hand). The post-saline pain intensity and pain areas at the FDI were significantly greater in patients with endometriosis than in control subjects (P <.05) but were not different between the groups for the back. An absence of enhancement of post-saline pain responses at the back in the endometriosis group suggests that saline-induced pain at the back appears to activate segmental inhibitory systems in patients with endometriosis. Manifestation of central sensitization in women with endometriosis is demonstrated by increased muscle nociceptor input in the form of increased post-saline pain intensity, pain areas at the FDI, and hypersensitivity to pressure stimulation. These findings provide new insights into the complex pain mechanisms associated with endometriosis.
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“Clinical evidence suggests this concept applies to painful endometriosis in women”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Bajaj et al., 2003
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Citations
Cites
The american college of rheumatology 1990 criteria for the classification of fibromyalgia
Wolfe, F., Smythe, H. A., Yunus, M. B., Bennett, R. M., Bombardier, C., Goldenberg, D. L., Tugwell, P., Campbell, S. M., Abeles, M., Clark, P., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330203 · Cited by 9,563
The McGill Pain Questionnaire: Major properties and scoring methods
Melzack, R. (1975) · Pain · doi:10.1016/0304-3959(75)90044-5 · Cited by 6,873
The short-form McGill pain questionnaire
Melzack, R. (1987) · Pain · doi:10.1016/0304-3959(87)91074-8 · Cited by 4,368
Bonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,537
Coderre, T. J., Katz, J., Vaccarino, A. L., & Melzack, R. (1993) · Pain · doi:10.1016/0304-3959(93)90161-h · Cited by 1,966
Arendt‐Nielsen, L., Graven‐Nielsen, T., Svarrer, H., & Svensson, P. J. (1996) · Pain · doi:10.1016/0304-3959(95)00115-8 · Cited by 417
Relationship of chronic pelvic pain to psychiatric diagnoses and childhood sexual abuse
Walker, E., Katon, W. J., Harrop-Griffiths, J., Holm, L., Russo, J. E., & Hickok, L. R. (1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.1.75 · Cited by 407
National Cancer Institute (2020) · Definitions · doi:10.32388/jzk490 · Cited by 356
Sensory dysfunction in fibromyalgia patients with implications for pathogenic mechanisms
Kosek, E., Ekholm, J., & Hansson, P. (1996) · Pain · doi:10.1016/s0304-3959(96)03188-0 · Cited by 348
Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study
Bajaj, P., Bajaj, P., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2001) · Pain · doi:10.1016/s0304-3959(01)00300-1 · Cited by 317
Self-citationGeneralised muscular hyperalgesia in chronic whiplash syndrome
Johansen, M. K., Graven‐Nielsen, T., Olesen, A. S., & Arendt‐Nielsen, L. (1999) · Pain · doi:10.1016/s0304-3959(99)00106-2 · Cited by 307
Hillen, T. I. J., Grbavac, S. L., Johnston, P. J., Straton, J. A. Y., & Keogh, J. (1999) · Journal of Adolescent Health · doi:10.1016/s1054-139x(98)00147-5 · Cited by 289
Hyperexcitability in fibromyalgia.
Sörensen, J., Graven‐Nielsen, T., Henriksson, K. G., Bengtsson, M., & Arendt‐Nielsen, L. (1998) · PubMed · Cited by 284
Balasch, J., Creus, M. T., Fábregues, F., Carmona, F., Ordï, J., Martínez‐Román, S., & Vanrell, J. A. (1996) · Human Reproduction · doi:10.1093/humrep/11.2.387 · Cited by 278
Multi-method assessment of experimental and clinical pain in patients with fibromyalgia
Lautenbacher, S., Rollman, G. B., & McCain, G. A. (1994) · Pain · doi:10.1016/0304-3959(94)90046-9 · Cited by 270
Giamberardino, M. A., Berkley, K. J., Iezzi, S., de Bigontina, P., & Vecchiet, L. (1997) · Pain · doi:10.1016/s0304-3959(97)03362-9 · Cited by 255
Hoheisel, U., Mense, S., Simons, D. G., & Yu, X. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90064-r · Cited by 247
Test-retest reliability of the pain drawing instrument
Margolis, R. B., Chibnall, J. T., & Tait, R. C. (1988) · Pain · doi:10.1016/0304-3959(88)90202-3 · Cited by 236
Peripheral and central hyperexcitability: Differential signs and symptoms in persistent pain
Coderre, T. J., & Katz, J. D. (1997) · Behavioral and Brain Sciences · doi:10.1017/s0140525x97251484 · Cited by 225
Observations on referred pain arising from muscle
(2001) · CRC Press eBooks · doi:10.3109/9780203214237-172 · Cited by 223
Relationship between stage, site and morphological characteristics of pelvic endometriosis and pain
dell'Endometriosi, G. I. P. L. S. (2001) · Human Reproduction · doi:10.1093/humrep/16.12.2668 · Cited by 167
McGill Pain Questionnaire Translated into Danish
Drewes, A. M., Helweg‐Larsen, S., Petersen, P., Brennum, J., Andereasen, A., Poulsen, L. H., & Jensen, T. S. (1993) · Clinical Journal of Pain · doi:10.1097/00002508-199306000-00002 · Cited by 158
Urban, M. O., & Gebhart, G. F. (1999) · Medical Clinics of North America · doi:10.1016/s0025-7125(05)70125-5 · Cited by 145
Hoheisel, U., & Mense, S. (1989) · Pain · doi:10.1016/0304-3959(89)90029-8 · Cited by 142
New Trends in Referred Pain and Hyperalgesia
Vecchiet, L., Albe-Fessard, D., & Lindblom, U. (1993) · Medical Entomology and Zoology · Cited by 139
Mense, S. (1994) · APS Journal · doi:10.1016/s1058-9139(05)80227-x · Cited by 135
Graven‐Nielsen, T., Babenko, V., Svensson, P. J., & Arendt‐Nielsen, L. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01480-7 · Cited by 124
Bajaj, P., Bajaj, P., Madsen, H., & Arendt‐Nielsen, L. (2002) · Clinical Journal of Pain · doi:10.1097/00002508-200205000-00007 · Cited by 123
Self-citationMenstrual cycle modulation of tender points
Hapidou, E. G., & Rollman, G. B. (1998) · Pain · doi:10.1016/s0304-3959(98)00087-6 · Cited by 115
Giamberardino, M. A., Berkley, K. J., Affaitati, G., Lerza, R., Centurione, L., Lapenna, D., & Vecchiet, L. (2002) · Pain · doi:10.1016/s0304-3959(01)00405-5 · Cited by 114
Modulation of myofascial pain by the reproductive hormones: A preliminary report
Dao, T. T. T., Knight, K., & Ton-That, V. (1998) · Journal of Prosthetic Dentistry · doi:10.1016/s0022-3913(98)70073-3 · Cited by 114
Cyclic changes in pain perception: An ROC analysis
Goolkasian, P. A. (1980) · Perception & Psychophysics · doi:10.3758/bf03198677 · Cited by 97
Vaginal hyperalgesia in a rat model of endometriosis
Berkley, K. J., Cason, A. M., Jacobs, H., Bradshaw, H. B., & Wood, E. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01906-1 · Cited by 96
Moen, M. H., & Stokstad, T. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03336-8 · Cited by 83
Giamberardino, M. A., Laurentis, S. D., Affaitati, G., Lerza, R., Lapenna, D., & Vecchiet, L. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01753-0 · Cited by 81
Roza, C., Laird, J. M. A., & Cerveró, F. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.4.1603 · Cited by 79
Selective Progesterone Receptor Modulators (SPRMs)
Chwalisż, K., Garg, R. C., Brenner, R., Schubert, G., & Elger, W. A. G. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02798.x · Cited by 77
Montero, P., C. BERNIS, Loukid, M., Hilali, K., & Baali, A. (1999) · Annals of Human Biology · doi:10.1080/030144699282741 · Cited by 63
Amodei, N., & Nelson‐Gray, R. O. (1989) · Journal of Behavioral Medicine · doi:10.1007/bf00844930 · Cited by 61
The spinal transmission of nociceptive information: Modulation by the caudal medulla
Bouhassira, D., Chitour, D., Villaneuva, L., & Bars, D. L. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00269-o · Cited by 59
Vecchiet, L., Galletti, R., Giamberardino, M. A., Dragani, L., & Marini, F. (1988) · Clinical Journal of Pain · doi:10.1097/00002508-198803000-00011 · Cited by 58
Howard, F. M. (2000) · The Journal of the American Association of Gynecologic Laparoscopists · doi:10.1016/s1074-3804(05)60360-x · Cited by 47
Endometriosis: An Overview of the Disease and Its Treatment
Frackiewicz, E. J. (2000) · Journal of the American Pharmaceutical Association (1996) · doi:10.1016/s1086-5802(16)31105-6 · Cited by 37
A comparison of primary dysmenorrhoea and intrauterine device related pain
Reading, A. E., & Newton, R. (1977) · Pain · doi:10.1016/0304-3959(77)90007-0 · Cited by 36
Bajaj, P., Bajaj, P., Madsen, H., M[oslash]ller, M., & Arendt‐Nielsen, L. (2002) · Journal of Pain · doi:10.1054/jpai.2002.128065 · Cited by 33
Self-citationPerimenstrual symptoms and working conditions among hospital workers in quebec
Tissot, F., & Messing, K. (1995) · American Journal of Industrial Medicine · doi:10.1002/ajim.4700270405 · Cited by 31
An Experimental Pain Model Based on Electric Stimulations of the Colon Mucosa
Drewes, A. M. (1999) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655299750025688 · Cited by 26
Controlled dilatation of the uterine cervix – an experimental visceral pain model
Bajaj, P., Drewes, A. M., Gregersen, H. N., Petersen, P., Madsen, H., & Arendt‐Nielsen, L. (2002) · Pain · doi:10.1016/s0304-3959(02)00182-3 · Cited by 25
Self-citationPain referral patterns in the pelvis
Demco, L. (2000) · The Journal of the American Association of Gynecologic Laparoscopists · doi:10.1016/s1074-3804(00)80037-7 · Cited by 23
Sedehizade, F., Klocke, R., & Jockusch, H. (1997) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199702)20:2 · Cited by 23
Drewes, A. M., Krarup, H. B., Hansen, J. B., Tage‐Jensen, U., & Arendt‐Nielsen, L. (1999) · Pain Research and Management · doi:10.1155/1999/516320 · Cited by 17
Psychological factors in IUD use—a review
Reading, A. E., & Newton, R. (1977) · Journal of Biosocial Science · doi:10.1017/s0021932000011147 · Cited by 13
Dubner, R. A. (1994) · Developments in critical care medicine and anestesiology · doi:10.1007/978-94-011-0816-4_2 · Cited by 8
Quantitative sensory testing in pain states
Stojanovic, M. P. (1998) · Current Review of Pain · doi:10.1007/s11916-998-0020-7 · Cited by 7
Cited by
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Vercellini, P., Viganò, P., Somigliana, E., & Fedele, L. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.255 · Cited by 1,940
Nnoaham, K. E., Hummelshoj, L., Webster, P., d’Hooghe, T., de Cicco Nardone, F., de Cicco Nardone, C., Jenkinson, C., Kennedy, S. H., & Zondervan, K. T. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.05.090 · Cited by 1,584
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Taylor, H. S., Kotlyar, A. M., & Flores, V. A. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00389-5 · Cited by 1,425
Vercellini, P., Fedele, L., Aimi, G., Pietropaolo, G., Consonni, D., & Crosignani, P. G. (2007) · Human Reproduction · doi:10.1093/humrep/del339 · Cited by 547
Berkley, K. J., Rapkin, A. J., & Papka, R. E. (2005) · Science · doi:10.1126/science.1111445 · Cited by 455
Metadata
- Authors
- Bajaj, P.
- Affiliations
- Aalborg University (DK)
- Corresponding author
- Bajaj, P
- ORCID
- Bajaj, P
- Venue
- The Journal of Pain
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 4
- Issue
- 7
- Pages
- 372-380
- ISSN
- 1526-5900 (ISSN-L)
- OpenAlex
- W2017658725
- Cited by
- 247
- References
- 57
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 18 · 2023: 13 · 2022: 7 · 2021: 11 · 2020: 18 · 2019: 11 · 2018: 15 · 2017: 8 · 2016: 8 · 2015: 11 · 2014: 12 · 2013: 10 · 2012: 6
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Pain (publishedVersion)
- PubMed (publishedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- endometriosis, central sensitization, referred pain, dysmenorrhea, pelvic pain
- MeSH terms
- Adult, Endometriosis, Female, Humans, Hyperalgesia, Injections, Intramuscular, Pain, Pain Measurement, Physical Stimulation, Psychophysics, Saline Solution, Hypertonic, Pain Threshold
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