The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
Open accessAbstract
In a prototypical model of multistage tumorigenesis involving pancreatic islets in RIP1-Tag2 transgenic mice, activation of insulin-like growth factor II (IGF-II) was previously shown to serve as a survival factor that inhibited apoptosis. Now IGF-1R, the receptor tyrosine kinase for IGF-II, has been found to be variably upregulated, first uniformly in dysplastic and angiogenic progenitors and then focally at the margins and in invasive regions of carcinomas. When the levels of IGF-1R were forcibly elevated throughout islet tumorigenesis, progression was accelerated at all stages in the pathway, although apoptosis was not differentially suppressed. Notably, encapsulated tumors were absent; instead, invasive carcinomas with downregulated E-cadherin were prevalent, and the majority of mice had local lymph node metastasis.
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Cites
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Bergers, G., Brekken, R., McMahon, G., Vu, T. H., Itoh, T., Tamaki, K., Tanzawa, K., Thorpe, P., Itohara, S., Werb, Z., et al. (2000) · Nature Cell Biology · doi:10.1038/35036374 · Cited by 2,797
Self-citationEffects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice
Bergers, G., Javaherian, K., Lo, K.-M., Folkman, J., & Hanahan, D. (1999) · Science · doi:10.1126/science.284.5415.808 · Cited by 988
Self-citationHiscox, S., & Jiang, W. G. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1002 · Cited by 126
Cited by
Insulin and insulin-like growth factor signalling in neoplasia
Pollak, M. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2536 · Cited by 2,059
Giraudo, E., Inoue, M., & Hanahan, D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422087 · Cited by 700
Self-citationCheung, H. W., Cowley, G. S., Weir, B. A., Boehm, J. S., Rusin, S., Scott, J. A., East, A., Ali, L. D., Lizotte, P. H., Wong, T. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109363108 · Cited by 423
Ulanet, D. B., Ludwig, D. L., Kahn, C. R., & Hanahan, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914076107 · Cited by 235
Self-citationJoyce, J. A., Laakkonen, P., Bernasconi, M., Bergers, G., Ruoslahti, E., & Hanahan, D. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00271-x · Cited by 211
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Metadata
- Authors
- Lopez, T., & Hanahan, D.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 1
- Issue
- 4
- Pages
- 339-353
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1972486056
- Cited by
- 268
- References
- 3
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lopez, T., & Hanahan, D. (2002). Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell. https://doi.org/10.1016/s1535-6108(02)00055-7
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