Association of the HGF/SF Receptor, c-met, with the Cell-Surface Adhesion Molecule, E-Cadherin, and Catenins in Human Tumor Cells
Abstract
Tumour cell metastatic potential is significantly enhanced following treatment with HGF/SF, the ligand for the c-met receptor tyrosine kinase. Following c-met activation in tumour cells, phosphorylation of beta-catenin occurs, together with loss of intercellular adhesion and a gain in the motile and invasive nature of the cell. In this study we show that c-met is co-localised with beta-catenin and E-cadherin at regions of cell-cell contact in human colon cancer (HRT18 and HT115) and two breast cancer (MCF7 and MDA MB 231) cell lines. Immunoprecipitation studies demonstrated an association between c-met and members of the cadherin adhesion complex in these epithelial tumour cells, along with the membrane tyrosine protein phophatase, PTPmu. We conclude that the HGF/SF receptor, c-met, together with members of the cadherin/catenin cell-cell adhesion system and PTPmu, may form part of a protein complex in E-cadherin positive tumour cells that acts to regulate intercellular adhesion following HGF/SF stimulation.
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Both c-Met and EGFR are known to form complexes with E-cadherin in cancer cells, and formation of such complexes is usually associated with inhibition of c-Met or EGFR phosphorylation.
“While both c-Met and EGFR are known to form complexes with E-cadherin in cancer cells, the formation of such complexes is usually associated with inhibition of c-Met or EGFR phosphorylation [36–38].”
From Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection (2023) · cites this paper as [36]
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- Authors
- Hiscox, S., & Jiang, W. G.
- Affiliations
- University of Wales (GB)
- Corresponding author
- Hiscox, S.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 261
- Issue
- 2
- Pages
- 406-411
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2122844290
- Cited by
- 126
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 6
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- c-Met, E-cadherin, β-catenin, catenins, cell-cell adhesion, cell-cell contact, colon cancer, breast cancer, metastasis, receptor tyrosine kinase, protein complex formation
- MeSH terms
- Breast Neoplasms, Cell Adhesion, Colonic Neoplasms, Cytoskeletal Proteins, Female, Humans, Microscopy, Fluorescence, Tumor Cells, Cultured, Trans-Activators, Cadherins, Protein Tyrosine Phosphatases, Microscopy, Confocal, Proto-Oncogene Proteins c-met, beta Catenin, Receptor-Like Protein Tyrosine Phosphatases, Class 2, Receptor-Like Protein Tyrosine Phosphatases, Class 8
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