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Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model
Open accessAbstract
Small cell lung cancer (SCLC) is a highly aggressive human tumor with a more than 95% mortality rate. Its ontogeny and molecular pathogenesis remains poorly understood. We established a mouse model for neuroendocrine (NE) lung tumors by conditional inactivation of Rb1 and Trp53 in mouse lung epithelial cells. Mice carrying conditional alleles for both Rb1 and Trp53 developed with high incidence aggressive lung tumors with striking morphologic and immunophenotypic similarities to SCLC. Most of these tumors, which we designate MSCLC (murine small cell lung carcinoma), diffusely spread through the lung and gave rise to extrapulmonary metastases. In our model, inactivation of both Rb1 and p53 was a prerequisite for the pathogenesis of SCLC.
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“RB is inactivated in more than 90% of human small-cell lung carcinomas (SCLC)”
From Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008) · cites this paper as [24]
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“mouse genetic studies have confirmed that RB is crucial in preventing the initiation of this lung cancer sub-type24”
From Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008) · cites this paper as [24]
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“When loss of Trp53 and Rb are combined, more tumours develop in mutant mice24,147–149 but it becomes difficult to dissect the respective roles of these two potent tumour suppressors.”
From Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008) · cites this paper as [24]
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Bhattacharjee, A., Richards, W. G., Staunton, J. E., Li, C., Monti, S., Vasa, P. P., Ladd, C., Beheshti, J., Bueno, R., Gillette, M. A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191502998 · Cited by 2,558
Neuroblastoma: biological insights into a clinical enigma
Brodeur, G. M. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1014 · Cited by 2,161
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-rasPreprint
Jackson, E. L., Willis, N. A., Mercer, K. L., Bronson, R. T., Crowley, D. G., Montoya, R., Jacks, T., & Tuveson, D. A. (2001) · Genes & Development · doi:10.1101/gad.943001 · Cited by 1,927
Effects of an Rb mutation in the mouse
Jacks, T., Fazeli, A., Schmitt, E. M., Bronson, R. T., Goodell, M. A., & Weinberg, R. A. (1992) · Nature · doi:10.1038/359295a0 · Cited by 1,755
The RB and p53 pathways in cancer
Sherr, C. J., & McCormick, F. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00102-2 · Cited by 1,690
Simplified mammalian DNA isolation procedure
Laird, P. W., Zijderveld, A., Linders, K., Rudnicki, M. A., Jaenisch, R., & Berns, A. J. M. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.15.4293 · Cited by 1,497
Self-citationDiversity of gene expression in adenocarcinoma of the lung
Garber, M. E., Troyanskaya, O. G., Schlüns, K., Petersen, S., Thäsler, Z., Pacyna-Gengelbach, M., van de Rijn, M., Rosen, G., Perou, C. M., Whyte, R. I., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241500798 · Cited by 1,301
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
Watkins, D. N., Berman, D. M., Burkholder, S. G., Wang, B., Beachy, P. A., & Baylin, S. B. (2003) · Nature · doi:10.1038/nature01493 · Cited by 1,082
Jonkers, J., Meuwissen, R. L. J., van der Gulden, H. M. L., Peterse, H. L., van der Valk, M., & Berns, A. J. M. (2001) · Nature Genetics · doi:10.1038/ng747 · Cited by 1,044
Self-citationMarino, S., Vooijs, M., van der Gulden, H., Jonkers, J., & Berns, A. (2000) · Genes & Development · doi:10.1101/gad.14.8.994 · Cited by 920
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Yachida, S., Zhong, Y., Pătrașcu, R., Davis, M. B., Morsberger, L. A., Griffin, C. A., Hruban, R. H., Laheru, D. A., & Iacobuzio–Donahue, C. A. (2011) · Pancreas · doi:10.1097/mpa.0b013e3182207a58 · Cited by 26
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Yu, L., Bazhenova, L. A., Gold, K. A., Tran, L., Hilburn, V., Vu, P., & Patel, S. P. (2022) · Translational Lung Cancer Research · doi:10.21037/tlcr-21-665 · Cited by 25
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Zhang, L., Yuan, Y., Lu, K. H., & Zhang, L. (2016) · BMC Bioinformatics · doi:10.1186/s12859-016-1085-7 · Cited by 25
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Jin, Y., Ma, D., Gramyk, T., Guo, C., Fang, R., Ji, H., & Shi, Y. G. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.118 · Cited by 25
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Yang, H., Liu, L., Zhou, C., Xiong, Y., Hu, Y., Yang, N., & Qu, J. (2019) · Medicine · doi:10.1097/md.0000000000014893 · Cited by 25
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Zhang, L., Zhu, X., Liu, C., Zhang, B., Zheng, J., Singh, P. K., Bshara, W., Wang, J., Gomez, E. C., Zhang, X., et al. (2022) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2022.11.019 · Cited by 24
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Zhou, M., Fan, J., Li, Z., Li, P., Sun, Y., Yang, Y., Zhou, X., Wang, J., Wang, Y., Qi, H., et al. (2019) · Respiratory Research · doi:10.1186/s12931-019-1205-9 · Cited by 24
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Chen, J., Hu, Y., Zhang, J., Wang, Q., Wu, X.-Z., Huang, W., Wang, Q., Cai, G., Wang, H., Ou, T., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106160 · Cited by 23
Dowlati, A., Abbas, A., Chan, T. A.-T., Henick, B. S., Wang, X., Doshi, P. D., Fu, P., Patel, J. D., Kuo, F., Chang, H., et al. (2022) · JCO Precision Oncology · doi:10.1200/po.22.00257 · Cited by 23
Yang, C., Ma, S., Zhang, J., Han, Y., Wan, L., Zhou, W., Dong, X., Yang, W., Chen, Y., Gao, L., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2317790121 · Cited by 23
Kitajima, S., Kohno, S., Kondoh, A., Sasaki, N., Nishimoto, Y., Li, F., Mohammed, M. S. A., Muranaka, H., Nagatani, N., Suzuki, M., et al. (2015) · Stem Cells · doi:10.1002/stem.1971 · Cited by 24
Rempe, D. A., Lelli, K. M., Vangeison, G., Johnson, R. S., & Federoff, H. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702203200 · Cited by 23
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Wang, Y., Rouggly, L. C., You, M., & Lubet, R. A. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394596-9.00007-x · Cited by 22
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Ruiz, S., Santos, M., & Paramio, J. M. (2006) · Cell Cycle · doi:10.4161/cc.5.6.2580 · Cited by 22
Jin, Y., Zhao, Q., Zhu, W., Feng, Y., Xiao, T., Zhang, P., Jiang, L., Hou, Y., Guo, C., Huang, H., et al. (2021) · National Science Review · doi:10.1093/nsr/nwab232 · Cited by 21
Horie, M., Miyashita, N., Mattsson, J. S. M., Mikami, Y., Sandelin, M., Brunnström, H., Micke, P., Nagase, T., & Saito, A. (2018) · The Journal of Pathology · doi:10.1002/path.5109 · Cited by 21
Hahn, W. C. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.007 · Cited by 21
Koba, H., Kimura, H., Yoneda, T., Ogawa, N., Tanimura, K., Tambo, Y., Sone, T., Hosomichi, K., Tajima, A., & Kasahara, K. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-21-536 · Cited by 20
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Small cell lung cancer: emerging subtypes, signaling pathways, and therapeutic vulnerabilities
Zhang, J., Zeng, X., Guo, Q., Sheng, Z., Chen, Y., Wan, S., Zhang, L., & Zhang, P. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00548-w · Cited by 21
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Shia, D. W., Choi, W., Vijayaraj, P., Vuong, V., Sandlin, J. M., Lu, M. M., Aziz, A. W., Marin, C., Aros, C. J., Sen, C., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02558-6 · Cited by 18
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Tenjin, Y., Matsuura, K., Kudoh, S., Usuki, S., Yamada, T., Matsuo, A., Sato, Y., Saito, H., Fujino, K., Wakimoto, J., et al. (2020) · Laboratory Investigation · doi:10.1038/s41374-020-00479-0 · Cited by 19
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Parisi, T., Bronson, R. T., & Lees, J. A. (2008) · Oncogene · doi:10.1038/onc.2008.406 · Cited by 19
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Shim, J., Choi, J., Park, M.-H., Kim, H., Kim, J.-H., Kim, S., Hong, D., Kim, S., Lee, J. E., Kim, C., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19424 · Cited by 18
Komori, H., Goto, Y., Kurayoshi, K., Ozono, E., Iwanaga, R., Bradford, A. P., Araki, K., & Ohtani, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-26860-0 · Cited by 18
Kitamura, H., Yazawa, T., Okudela, K., Shimoyamada, H., & Sato, H. (2008) · The Open Pathology Journal · doi:10.2174/1874375700802010106 · Cited by 18
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Fisher, E., Lana‐Elola, E., Watson, S. D., Vassiliou, G. S., & Tybulewicz, V. L. J. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.001644 · Cited by 19
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Safari, R., & Meuwissen, R. L. J. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2297-0_5 · Cited by 17
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Yang, X., Rosa, F. G. L., Genova, E. E., Huber, K. M., Schaack, J. B., DeGregori, J. V., Serkova, N. J., Li, Y., Su, L., Kessler, E. R., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074809 · Cited by 17
Verckist, L., Lembrechts, R., Thys, S., Pintelon, I., Timmermans, J., Brouns, I., & Adriaensen, D. (2017) · Respiratory Research · doi:10.1186/s12931-017-0571-4 · Cited by 17
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Takagi, Y., Nakahara, Y., Hosomi, Y., & Hishima, T. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-529 · Cited by 18
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Kim, K., Kim, D.-W., Kim, Y., Tang, J., Kirk, N., Gan, Y., Kim, B.-J., Fang, B., Park, J., Zheng, Y., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-1170 · Cited by 16
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Tenjin, Y., Nakamura, K., Ishizuka, S., Saruwatari, K., Sato, R., Tomita, Y., Saeki, S., Ichiyasu, H., Fujii, K., Ito, T., et al. (2019) · Internal Medicine · doi:10.2169/internalmedicine.2988-19 · Cited by 16
Vormer, T. L., Foijer, F., Wielders, C. L. C., & Riele, H. T. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00313-08 · Cited by 16
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Zhang, Q., Lee, S. B., Chen, X., Stevenson, M. E., Pan, J., Xiong, D., Zhou, Y., Miller, M. S., Lubet, R. A., Wang, Y., et al. (2019) · Nano Letters · doi:10.1021/acs.nanolett.8b04309 · Cited by 16
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Yousefi, M., Boross, G. Z., Weiss, C. V., Murray, C. W., Hebert, J. D., Cai, H., Ashkin, E. L., Karmakar, S., Andrejka, L., Chen, L. C., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-0059 · Cited by 15
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Sen, M., Akeno, N., Reece, A. L., Miller, A. L., Simpson, D. S., & Wikenheiser‐Brokamp, K. A. (2017) · Oncogenesis · doi:10.1038/oncsis.2017.5 · Cited by 15
Akeno, N., Reece, A. L., Callahan, M. K., Miller, A. L., Kim, R. G., He, D., Lane, A., Moulton, J. S., & Wikenheiser‐Brokamp, K. A. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0353 · Cited by 15
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Linnoila, R. I., Naizhen, X., Meuwissen, R. L. J., Berns, A. J. M., & DeMayo, F. J. (2004) · Experimental Lung Research · doi:10.1080/01902140490495002 · Cited by 15
Self-citationHaworth, R., Woodfine, J. A., McCawley, S. J., Pilling, A. M., Lewis, D. J., & Williams, T. C. (2007) · Toxicologic Pathology · doi:10.1080/01926230701460000 · Cited by 15
He, N., Kim, N., Song, M., Park, C., Kim, S., Park, E. Y., Yim, H. Y., Kim, K., Park, J. H., Kim, K. I., et al. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-0297 · Cited by 15
Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomasPreprint
Norton, J. P., Augert, A., Eastwood, E., Basom, R., Rudin, C. M., & MacPherson, D. P. (2021) · Genes & Development · doi:10.1101/gad.348316.121 · Cited by 16
Chen, Y., Liu, X., Sun, Y., Liu, K., Ding, D., Song, S., & Tan, W. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03184-6 · Cited by 14
RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α
Liu, H., Tang, Y., Singh, A., Vong, J. S. L., Cordero, J., Mathes, A., Gao, R., Jia, Y., Garvalov, B. K., Acker, T., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60223-4 · Cited by 14
Small cell lung cancer; recent advances of its biology and therapeutic perspective
Hayashi, R., & Inomata, M. (2021) · Respiratory Investigation · doi:10.1016/j.resinv.2021.10.008 · Cited by 14
CDK9 inhibition as an effective therapy for small cell lung cancer
Capuccino, L. V., Kleitke, T., Szokol, B., Svajda, L., Martín, F., Bonechi, F., Krekó, M., Azami, S., Montinaro, A., Wang, Y., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06724-4 · Cited by 14
Cell plasticity in patients with NSCLC: The controversial origins of transformed SCLC
Liang, X., Lin, A., Wang, Q., Zhang, J., & Luo, P. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112909 · Cited by 14
Aktar, R., Dietrich, A., Tillner, F., Kotb, S., Löck, S., Willers, H., Baumann, M. A., Krause, M., & Bütof, R. (2018) · British Journal of Radiology · doi:10.1259/bjr.20180539 · Cited by 14
THE MOUSE TUMOR BIOLOGY DATABASE: INTEGRATED ACCESS TO MOUSE CANCER BIOLOGY DATA
Krupke, D. M., Näf, D., Vincent, M. J., Allio, T., Mikaelian, I., Sundberg, J. P., Bult, C. J., & Eppig, J. T. (2005) · Experimental Lung Research · doi:10.1080/01902140490495633 · Cited by 14
The evolving landscape of brain metastasis: volume II
Valiente, M., Anders, C. K., Boire, A. A., Izar, B., Kotecki, N., Malladi, S., Massagué, J., Moss, N. S., Neman, J., Preusser, M., et al. (2025) · Trends in cancer · doi:10.1016/j.trecan.2025.11.007 · Cited by 16
Meder, L., Orschel, C. I., Bouchez, C. L., Gholamipoorfard, R., Orschel, C. V., Stahl, D. J., Kreer, C., Koker, M., Nill, M., Kocak, I. G., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66800-x · Cited by 13
Progress in the knowledge on the transformation of lung adenocarcinoma to small-cell lung cancer
Wang, A., Han, C., Zhao, H., Zheng, Z., Ye, X., & Shan, R. (2023) · Journal of Cancer Research and Therapeutics · doi:10.4103/jcrt.jcrt_1842_22 · Cited by 14
Small Cell Lung Cancer Plasticity Enables NFIB-Independent Metastasis
Ko, J. H., Lambert, K. E., Bhattacharya, D., Lee, M. C., Colón, C. I., Hauser, H. F., & Sage, J. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-1079 · Cited by 13
Liu, S., Shao, F., Wang, Y., Zhang, Y., Yu, H., Zhang, N., He, L., Kong, Q., Jiang, H., & Dong, Z. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06443-w · Cited by 13
Meder, L., Orschel, C. I., Otto, C. J., Koker, M., Brägelmann, J., Ercanoglu, M. S., Dähling, S., Compes, A., Selenz, C., Nill, M., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.166402 · Cited by 13
Surien, O., Ghazali, A. R., & Masre, S. F. (2019) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/1617 · Cited by 13
Yazawa, T. (2015) · Pathology International · doi:10.1111/pin.12267 · Cited by 13
Atypical pulmonary carcinoid tumour in a 28-year-old nonsmoker with Prader–Willi syndrome: Figure 1–
Nenekidis, I., Stathopoulos, G. T., Anagnostakou, V., Kokkori, A., Dedeilias, P., Kokotsakis, J. N., Argiriou, M., & Zisis, C. (2011) · European Respiratory Journal · doi:10.1183/09031936.00034711 · Cited by 13
Lázaro, S., Pérez-Crespo, M., Enguita, A. B., Hernández, P., Martínez‐Palacio, J., Oteo, M., Sage, J., Paramio, J. M., & Santos, M. (2016) · Oncotarget · doi:10.18632/oncotarget.13875 · Cited by 13
Metadata
- Authors
- Meuwissen, R., Linn, S. C., Linnoila, R. I., Zevenhoven, J., Mooi, W. J., & Berns, A.
- Affiliations
- The Netherlands Cancer Institute (NL)
- National Cancer Institute (US)
- Corresponding author
- Berns, Anton
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 4
- Issue
- 3
- Pages
- 181-189
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1978286483
- Cited by
- 643
- References
- 49
- Citations by year
- 2026: 22 · 2025: 41 · 2024: 30 · 2023: 43 · 2022: 43 · 2021: 40 · 2020: 33 · 2019: 43 · 2018: 34 · 2017: 34 · 2016: 27 · 2015: 31 · 2014: 27 · 2013: 24 · 2012: 16
- FWCI
- 8.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- KWF Kankerbestrijding
- Topics
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Keywords
- small cell lung cancer, lung neuroendocrine tumors, Trp53, RB1, conditional knockout mice, carcinogenesis, p53, retinoblastoma protein, lung epithelial cells, metastasis, mouse model
- MeSH terms
- Animals, DNA-Binding Proteins, Lung Neoplasms, Mice, Transgenic, Transcription Factors, Gene Expression Regulation, Neoplastic, Genes, p53, Tumor Suppressor Protein p53, Retinoblastoma Protein, Carcinoma, Small Cell, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins
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