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Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A

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The Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis

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Inhibition of Protein Phosphatase 2A (PP2A) Prevents Mcl-1 Protein Dephosphorylation at the Thr-163/Ser-159 Phosphodegron, Dramatically Reducing Expression in Mcl-1-amplified Lymphoma Cells

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The structure of the PP2A regulatory subunit B56γ: The remaining piece of the PP2A jigsaw puzzle

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Immortalized cells as experimental models to study cancer

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Farnesyltransferase Inhibitor SCH66336 Induces Rapid Phosphorylation of Eukaryotic Translation Elongation Factor 2 in Head and Neck Squamous Cell Carcinoma Cells

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Cyclin E and SV40 Small t Antigen Cooperate to Bypass Quiescence and Contribute to Transformation by Activating CDK2 in Human Fibroblasts*

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AKT Regulates Mitotic Progression of Mammalian Cells by Phosphorylating MASTL, Leading to Protein Phosphatase 2A Inactivation

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Molecular Mechanisms of Epigenetic Regulators as Activatable Targets in Cancer Theranostics

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Role of a Novel Functional Variant in the PPP2R1A Promoter on the Regulation of PP2A-Aalpha and the Risk of Hepatocellular Carcinoma

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Interaction between Salt-inducible Kinase 2 and Protein Phosphatase 2A Regulates the Activity of Calcium/Calmodulin-dependent Protein Kinase I and Protein Phosphatase Methylesterase-1

Lee, C., Yang, F.-C., Chang, H.-Y., Chou, H., Tan, B. C., & Lee, S.-C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.540229 · Cited by 17

Serine-threonine protein phosphatases: Lost in translation

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BRAF V600E Overrides NOTCH Signaling in Thyroid Cancer

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Regulation of Virus Replication by BK Polyomavirus Small T Antigen

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CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer

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Role of "oncogenic nexus" of CIP2A in breast oncogenesis: how does it work?

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Papillomavirus E7 Oncoproteins Share Functions with Polyomavirus Small T Antigens

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PP2ACdc55is required for multiple events during meiosis I

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Protein phosphatase 2A Aα regulates Aβ protein expression and stability

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PP2A Phosphatase as an Emerging Viral Host Factor

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Establishment of mouse intestinal myofibroblast cell lines

Kawasaki, H. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i17.2629 · Cited by 15

Intracellular antibody targeting HBx suppresses invasion and metastasis in hepatitis B virus‐related hepatocarcinogenesis via protein phosphatase 2A‐B56γ ‐mediated dephosphorylation of protein kinase B

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Blockade of the BAK Hydrophobic Groove by Inhibitory Phosphorylation Regulates Commitment to Apoptosis

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A Functional Genomics Analysis of the B56 Isoforms of Drosophila Protein Phosphatase 2A

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Enhanced anticancer activity of a protein phosphatase 2A inhibitor on chemotherapy and radiation in head and neck squamous cell carcinoma

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A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during Mitosis

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PPP2R4 dysfunction promotes KRAS-mutant lung adenocarcinoma development and mediates opposite responses to MEK and mTOR inhibition

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Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma

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HEAT Repeat 1 Motif Is Required for B56γ-containing Protein Phosphatase 2A (B56γ-PP2A) Holoenzyme Assembly and Tumor-suppressive Function

Nobumori, Y., Shouse, G., Fan, L., & Liu, X. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.334094 · Cited by 13

The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1

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Clonal divergence in lung cancer development is associated with allelic loss on chromosome 4

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Correction: TBC1D3, a Hominoid-Specific Gene, Delays IRS-1 Degradation and Promotes Insulin Signaling by Modulating p70 S6 Kinase Activity

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Inhibition of protein phosphatase 2A attenuates titanium-particle induced suppression of bone formation

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Control of cell migration by the novel protein phosphatase-2A interacting protein inka2

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Phosphorylation of axin within biomolecular condensates counteracts its tankyrase-mediated degradation

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The α4‐containing form of protein phosphatase 2A in liver and hepatic cells

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Affinity-based profiling of endogenous phosphoprotein phosphatases by mass spectrometry

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Identification of a novel conserved mixed-isoform B56 regulatory subunit and spatiotemporal regulation of protein phosphatase 2A during Xenopus laevisdevelopment

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Intranasal Immunization of Lambs with Serine/Threonine Phosphatase 2A against Gastrointestinal Nematodes

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Emerging Roles of B56 Phosphorylation and Binding Motif in PP2A-B56 Holoenzyme Biological Function

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Anti-tumoral Effect of a Cell Penetrating and Interfering Peptide Targeting PP2A/SET Interaction

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Retroviral Cyclin Enhances Cyclin-Dependent Kinase-8 Activity

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Recent insights into Protein Phosphatase 2A structure and regulation: the reasons why PP2A is no longer considered as a lazy passive housekeeping enzyme

Martin, M., Kettmann, R., & Dequiedt, S. (2010) · Open Repository and Bibliography (University of Liège) · Cited by 10

A SMAP in the face for cancer

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Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor

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PME ‐1 is regulated by USP 36 in ERK and Akt signaling pathways

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The Use of RNA Interference to Analyze Protein Phosphatase Function in Mammalian Cells

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Isolation and Characterization of PP2A Holoenzymes Containing FLAG-Tagged B Subunits

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The B56γ3-containing protein phosphatase 2A attenuates p70S6K-mediated negative feedback loop to enhance AKT-facilitated epithelial-mesenchymal transition in colorectal cancer

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p27kip1 Protein Levels Reflect a Nexus of Oncogenic Signaling during Cell Transformation

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L‐Selectin Expression is Influenced by Phosphatase Activity in Chronic Lymphocytic Leukemia

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A functional interaction between liprin-α1 and B56γ regulatory subunit of protein phosphatase 2A supports tumor cell motility

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Binding and Kinetic Analysis of Human Protein Phosphatase PP2A Interactions with Caspase 9 Protein and the Interfering Peptide C9h

Dorgham, K., Murail, S., Tufféry, P., Savier, É., Bravo, J., & Rebollo, A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102055 · Cited by 8

Efficacy of an anti-cancer strategy targeting SET in canine osteosarcoma

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A fail-safe system to prevent oncogenesis by senescence is targeted by SV40 small T antigen

Oshikawa, K., Matsumoto, M., Kodama, M., Shimizu, H., & Nakayama, K. I. (2019) · Oncogene · doi:10.1038/s41388-019-1139-1 · Cited by 8

The Interaction Mechanism of Intrinsically Disordered PP2A Inhibitor Proteins ARPP-16 and ARPP-19 With PP2A

Thapa, C. J., Roivas, P., Haataja, T., Permi, P., & Pentikäinen, U. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.650881 · Cited by 8

A systems biology approach for the study of cumulative oncogenes with applications to the MAPK signal transduction pathway

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Small-molecule modulators of B56-PP2A restore 4E-BP function to suppress eIF4E-dependent translation in cancer cells

Lum, M. A., Jonas, K. A., Parmar, S., Black, A. R., O’Connor, C. M., Dobersch, S., Yamamoto, N., Robertson, T. M., Schutter, A., Giambi, M., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci176093 · Cited by 7

Loss of PP2A and PTEN immunoexpression coexists with survivin overexpression in adenomyosis

Zhang, H., Liu, J., Ζhao, X., Liang, B.-R., Wen, Z., & Li, M. (2014) · Reproductive Biology · doi:10.1016/j.repbio.2014.04.004 · Cited by 7

Infection & neoplastic growth 101: the required reading for microbial pathogens aspiring to cause cancer.

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Polyomavirus small T antigen transactivates genes by its ability to provoke the synthesis and the stabilization of MYC

Klucky, B., & Wintersberger, E. (2007) · Oncogene · doi:10.1038/sj.onc.1210458 · Cited by 7

Pathogenic de novo variants in PPP2R5C cause a neurodevelopmental disorder within the Houge-Janssens syndrome spectrum

Verbinnen, I., Douzgou, S., Hsieh, T., Lesmann, H., Kirchhoff, A., Geneviève, D., Brimble, E., Lenaerts, L., Haesen, D., Levy, R. J., et al. (2025) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2025.01.021 · Cited by 6

Escape from Cellular Quiescence

Sotillo, E., & Graña, X. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1770-6_1 · Cited by 6

SET levels contribute to cohesion fatigue

Yang, L., Zhang, Q., Niu, T., & Liu, H. (2021) · Molecular Biology of the Cell · doi:10.1091/mbc.e20-12-0778 · Cited by 6

Cancer stem cell phosphatases

Momeny, M., Arsiola, T., & Westermarck, J. K. (2021) · Biochemical Journal · doi:10.1042/bcj20210254 · Cited by 6

Identification and functional analyses of polymorphism haplotypes of protein phosphatase 2A-Aα gene promoter

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Identification and Functional Analysis of Variant Haplotypes in the 5′-Flanking Region of Protein Phosphatase 2A-Bδ Gene

Chen, H., Lin, L., Chen, Y., Wan, J., Luo, J., Zhang, C.-Z., Li, X., Hu, Y.-M., Mai, J., Chen, W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035524 · Cited by 6

GRB10 sustains AR activity by interacting with PP2A in prostate cancer cells

Hao, J., Ci, X., Wang, Y., Choi, S. Y. C., Sullivan, S. E., Xue, H., Wu, R., Dong, X., Haegert, A. M., Collins, C. C., et al. (2020) · International Journal of Cancer · doi:10.1002/ijc.33335 · Cited by 6

Infection & Neoplastic Growth 101

Bertout, J. A., & Thomas‐Tikhonenko, A. (2006) · Cancer treatment and research · doi:10.1007/0-387-26283-0_8 · Cited by 6

PPTR-1 CounterAkts Insulin Signaling

Shaw, R. J., & Dillin, A. G. (2009) · Cell · doi:10.1016/j.cell.2009.02.029 · Cited by 6

The level of oncogene H-Ras correlates with tumorigenicity and malignancy

Sun, B., Gao, Y., Deng, L., Li, G., Cheng, F., & Wang, X. (2008) · Cell Cycle · doi:10.4161/cc.7.7.5622 · Cited by 5

Molecular dissection on inhibition of Ras-induced cellular senescence by small t antigen of SV40

Shang, D., Zhou, T., Zhuang, X., Wu, Y., Liu, H., & Tu, Z. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04275-5 · Cited by 5

Chromosome instability in yeast and its implications to the study of human cancer

Wang, Y. (2007) · Frontiers in bioscience · doi:10.2741/2826 · Cited by 5

A PP2A molecular glue overcomes RAS/MAPK inhibitor resistance in KRAS-mutant non–small cell lung cancer

Raines, B., Tseng-Rogenski, S. S., Dowdican, A. C., Peris, I., Hinderman, M., Zawacki, K. P., Barrie, K., Onishi, G. H., Dymond, A. M., Luther, T. K., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci193790 · Cited by 5

Germline mutations in PPP2R1B in patients with a personal and family history of cancer

Mazhar, S., O’Connor, C. M., Harold, A., Dowdican, A. C., Ulintz, P., Hanson, E. N., Zhang, Y., Jacobs, M. F., Merajver, S. D., Jackson, M. W., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.186288 · Cited by 4

Defective heat shock factor 1 inhibits the growth of fibrosarcoma derived from simian virus 40/T antigen-transformed MEF cells

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Novel immune checkpoint-related gene model to predict prognosis and treatment responsiveness in low-grade gliomas

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A PP2A active site mutant impedes growth and causes misregulation of native catalytic subunit expression

Lizotte, D. L., Blakeslee, J. J., Siryaporn, A., Heath, J. T., & DeLong, A. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21514 · Cited by 4

A Nonsynonymous/Synonymous Substitution Analysis of the B56 Gene Family Aids in Understanding B56 Isoform Diversity

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Life support: the α4 phosphatase subunit in cell survival and apoptosis

Saleh, M., Pagliari, L. J., & Green, D. R. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.04.001 · Cited by 4

Polyomaviruses and Cancer

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Prognostic Impact of PPP2R5C Gene Expression in Adult Acute Myeloid Leukemia Patients with Normal Cytogenetics

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