Wnt signaling and cancer

Polakis, Paul

doi:10.1101/gad.14.15.1837

PreprintCited by 3,183Wnt/β-catenin signaling in development and cancerSignaling Pathways in DiseaseHedgehog Signaling Pathway Studies

Wnt signaling and cancer

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Polakis, Paul·2000·Genes & Development

DOI 10.1101/gad.14.15.1837

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Abstract

The regulation of cell growth and survival can be subverted by a variety of genetic defects that alter transcriptional programs normally responsible for controlling cell number. High throughput analysis of these gene expression patterns should ultimately lead to the identification of minimal expression profiles that will serve as common denominators in assigning a cancer to a given category. In the course of defining the common denominators, though, we should not be too surprised to find that cancers within a single category may nevertheless exhibit seemingly disparate genetic defects. The wnt pathway has already provided an outstanding example of this. We now know of three regulatory genes in this pathway that are mutated in primary human cancers and several others that promote experimental cancers in rodents (Fig. 1). In all of these cases the common denominator is the activation of gene transcription by -catenin. The resulting gene expression profile should provide us with a signature common to those cancers carrying defects in the wnt pathway. In this review, the wnt pathway will be covered from the perspective of cancer, with emphasis placed on molecular defects known to promote neoplastic transformation in humans and in animal models.

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Constitutive activation of the Wnt signaling pathway is implicated in cancer development in several other organs.
“Constitutive activation of this pathway is also implicated in cancer development in several other organs (140).”
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LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
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Function and biological roles of the Dickkopf family of Wnt modulators
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The role of the Rho GTPases in neuronal developmentPreprint
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The Promise and Perils of Wnt Signaling Through β-Catenin
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Notch1 functions as a tumor suppressor in mouse skin
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Side Population in Human Lung Cancer Cell Lines and Tumors Is Enriched with Stem-like Cancer Cells
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Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation
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Phosphorylation of β-Catenin by AKT Promotes β-Catenin Transcriptional Activity*
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Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling
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How the ubiquitin–proteasome system controls transcription
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GSK3 inhibitors: development and therapeutic potential
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The role of Notch in tumorigenesis: oncogene or tumour suppressor?
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The Structure of the β-Catenin/E-Cadherin Complex and the Molecular Basis of Diverse Ligand Recognition by β-Catenin
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Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
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BMP-2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop
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Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity
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Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathwayPreprint
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Mining the Wnt pathway for cancer therapeutics
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A core function for p120-catenin in cadherin turnover
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Gli and hedgehog in cancer: tumours, embryos and stem cells
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Aberrant Wnt/β-Catenin Pathway Activation in Idiopathic Pulmonary Fibrosis
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Authors: Polakis, P.
Affiliations: Genentech (US)
Corresponding author: Polakis, Paul
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2000-08-01
Volume: 14
Issue: 15
Pages: 1837-1851
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.14.15.1837
OpenAlex: W2239090104
Cited by: 3,183
References: 190
Citations by year: 2026: 6 · 2025: 12 · 2024: 25 · 2023: 43 · 2022: 39 · 2021: 46 · 2020: 56 · 2019: 67 · 2018: 71 · 2017: 86 · 2016: 110 · 2015: 144 · 2014: 138 · 2013: 147 · 2012: 174
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Keywords: Wnt signaling, β-catenin, cancer, oncogenic transformation, transcriptional activation, gene expression profiles, experimental tumor model
MeSH terms: Dishevelled Proteins, Animals, Cytoskeletal Proteins, Humans, Neoplasms, Phosphoprotein Phosphatases, Phosphoproteins, Proto-Oncogene Proteins, Transcription Factors, Signal Transduction, Trans-Activators, Calcium-Calmodulin-Dependent Protein Kinases, Adenomatous Polyposis Coli Protein, Zebrafish Proteins, Glycogen Synthase Kinase 3, Adaptor Proteins, Signal Transducing, Wnt Proteins, beta Catenin

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