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Cited by 1,183

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Tight junctions of the blood–brain barrier

Wolburg, Hartwig, Lippoldt, Andrea·2002·Vascular Pharmacology
DOI 10.1016/s1537-1891(02)00200-8
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Abstract

1. The blood-brain barrier is essential for the maintenance and regulation of the neural microenvironment. The main characteristic features of blood-brain barrier endothelial cells are an extremely low rate of transcytotic vesicles and a restrictive paracellular diffusion barrier. 2. Endothelial blood-brain barrier tight junctions differ from epithelial tight junctions, not only by distinct morphological and molecular properties, but also by the fact that endothelial tight junctions are more sensitive to microenvironmental than epithelial factors. 3. Many ubiquitous molecular tight junction components have been identified and characterized including claudins, occludin, ZO-1, ZO-2, ZO-3, cingulin and 7H6. Signaling pathways involved in tight junction regulation include G-proteins, serine-, threonine- and tyrosine-kinases, extra and intracellular calcium levels, cAMP levels, proteases and cytokines. Common to most of these pathways is the modulation of cytoskeletal elements and the connection of tight junction transmembrane molecules to the cytoskeleton. Additionally, crosstalk between components of the tight junction- and the cadherin-catenin system of the adherens junction suggests a close functional interdependence of the two cell-cell contact systems. 4. Important new molecular aspects of tight junction regulation were recently elucidated. This review provides an integration of these new results.

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Metadata

Authors
Wolburg, H., & Lippoldt, A.
Venue
Vascular Pharmacology
Publisher
Elsevier BV
Published
2002-06
Volume
38
Issue
6
Pages
323-337
ISSN
1537-1891
DOI
10.1016/s1537-1891(02)00200-8
OpenAlex
W1796054280
Cited by
1,183
References
8
FWCI
17.68
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Tight junctions of the blood–brain barrier. https://app.cochat.ai/papers/10.1016/s1537-1891(02)00200-8
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Wolburg, H., & Lippoldt, A. (2002). Tight junctions of the blood–brain barrier. Vascular Pharmacology. https://doi.org/10.1016/s1537-1891(02)00200-8

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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