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Cited by 444Barrier Structure and Function StudiesCerebrospinal fluid and hydrocephalusIon Transport and Channel Regulation

Junctions in the meninges and marginal glia.

Nabeshima, Sachio, Reese, T. S., Landis, Dennis M. D., Brightman, M. W.·1975·Journal of Comparative Neurology
DOI 10.1002/cne.901640202
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Abstract

The meninges of various mammals were prepared for examination with the electronmicroscope by thin sectioning or freeze-fracturing. Particular attention was given to the distribution of tight junctions in order to determine the basis for the meningeal barrier between the blood circulating in dural vessels and the cerebrospinal fluid in the subarachnoid space. While some dural blood vessels are fenestrated, those in the subarachnoid space are not and their component endothelial cells are joined by an extensive system of tight junctions. An extensive and continuous system of tight junctions was also found in a layer of specialized cells at the border of the arachnoid with the dura. This arachnoid barrier layer is apparently the only basis of the meningeal barrier because often cellular layers in the dura and arachnoid lack tight junctions although they are linked by gap junctions and desmosomes. In particular, tight junctions are lacking at the border of the "subdural space" which is actually a fascial plane within the dura. Tight junctions are also lacking between astrocytes at the surface of the brain but these cells are linked by gap junctions and a new type of intercellular junction. The distribution of these junctions, as well as assemblies of intramembranous particles at the astrocytic border, raises the question whether this layer might have a role in the exchange of certain substances between the brain and cerebrospinal fluid.

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  • The pial vasculature has barrier properties and is part of the meninges blood-CSF barrier.

    “Several studies show this vasculature has barrier properties and are therefore part of the meninges blood-CSF barrier.”

    From Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease (2021) · cites this paper as Nabeshima et al., 1975

  • Arachnoid barrier cells are epithelial-like cells connected by tight and adherens junctions that regulate the movement of pathogens, molecules, and cells into and out of the CSF and brain parenchyma.

    “Segregating the outer and inner meningeal compartments is the epithelial-like arachnoid barrier cells, connected by tight and adherens junctions, which regulate the movement of pathogens, molecules, and cells into and out of the cerebral spinal fluid (CSF) and brain parenchyma.”

    From Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease (2021) · cites this paper as Nabeshima et al., 1975

  • Previous observations indicate that the arachnoid constitutes an impermeable barrier layer between CSF and dura mater.

    “previous observations indicating that the arachnoid constitutes an impermeable barrier layer between the CSF and dura mater8,9”

    From Cerebrospinal fluid tracer efflux to parasagittal dura in humans (2020) · cites this paper as [8]

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Authors
Nabeshima, S., Reese, T. S., Landis, D. M. D., & Brightman, M. W.
Affiliations
National Institutes of Health (US)
ORCID
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1975-11-15
Volume
164
Issue
2
Pages
127-169
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.901640202
OpenAlex
W1975635783
Cited by
444
References
25
Citations by year
2026: 15 · 2025: 16 · 2024: 25 · 2023: 14 · 2022: 27 · 2021: 12 · 2020: 11 · 2019: 12 · 2018: 12 · 2017: 20 · 2016: 9 · 2015: 7 · 2014: 8 · 2013: 13 · 2012: 7
FWCI
7.65
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 10556 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
tight junctions, subarachnoid space, cerebrospinal fluid, gap junctions, desmosomes, astrocytes, subdural space, intercellular junctions, meninges
MeSH terms
Animals, Haplorhini, Arachnoid, Astrocytes, Cats, Chinchilla, Desmosomes, Dura Mater, Freeze Fracturing, Intercellular Junctions, Macaca, Meninges, Microscopy, Electron, Neuroglia, Pia Mater, Rabbits, Species Specificity, Mice, Rats

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