The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Math1-driven GFP expression in the developing nervous system of transgenic mice
Abstract
Math1 is a bHLH transcription factor expressed in neural progenitor cells in multiple regions of the nervous system. Previously we identified a Math1 enhancer that directs expression of reporter genes in a Math1 specific pattern [Development 127 (2000) 1185]. We have used a portion of this enhancer to drive expression of a nuclear GFP reporter in the Math1 lineage in transgenic mice. In this transgenic mouse strain, GFP is expressed in Math1 domains in the (1). developing spinal cord in progenitors to dI1 dorsal interneurons, (2). granule-cell progenitors in the developing cerebellum, (3). Merkel cells in the skin, and (4). hair cells in the developing vestibular and auditory systems. Furthermore, non-Math1 related expression is detected that is likely due to the absence of inhibitory regulatory sequences from the transgene. These expression domains include (1). the apical ectodermal ridge in developing limbs, (2). post-mitotic cells in the developing cortex and spinal cord, (3). the dentate gyrus, (4). retina, and (5). olfactory epithelium. Because GFP marks specific neuronal cell types in living tissue, this transgenic strain is a powerful tool for future studies on the development and electrophysiological properties of distinct cell types in the central nervous system and in sensory systems.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, as mentioned earlier in Figure 4D′, the SOX2+ nuclei speckles in the skin epithelium were Atoh1/nGFP+ ISL1+ cells that arose in the epithelium between days 14–16 (Figure 5F–F″), reminiscence of Merkel cells, which are touch sensing cells in the epidermis (Lumpkin et al., 2003; Perdigoto et al., 2014).”
From Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids (2018) · cites this paper as Lumpkin et al., 2003
Citations
Cites
NeuN, a neuronal specific nuclear protein in vertebratesxs
Mullen, R. J., Buck, C. R., & Smith, A. M. (1992) · Development · doi:10.1242/dev.116.1.201 · Cited by 2,351
Math1 : An Essential Gene for the Generation of Inner Ear Hair Cells
Bermingham, N. A., Hassan, B. A., Price, S. D., Vollrath, M. A., Ben‐Arie, N., Eatock, R. A., Bellen, H. J., Lysakowski, A., & Zoghbi, H. Y. (1999) · Science · doi:10.1126/science.284.5421.1837 · Cited by 1,093
Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
Liem, K. F., Tremml, G., Roelink, H., & Jessell, T. M. (1995) · Cell · doi:10.1016/0092-8674(95)90276-7 · Cited by 1,071
The structure and function of a slowly adapting touch corpuscle in hairy skin
Iggo, A., & Muir, A. R. (1969) · Journal of Physiology · doi:10.1113/jphysiol.1969.sp008721 · Cited by 749
Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons
Dodd, J., Brenner‐Morton, S., Karagogeos, D., Yamamoto, M., & Jessell, T. M. (1988) · Neuron · doi:10.1016/0896-6273(88)90194-8 · Cited by 741
Math1 is essential for genesis of cerebellar granule neurons
Ben‐Arie, N., Bellen, H. J., Armstrong, D. L., McCall, A. E., Gordadze, P. R., Guo, Q., Matzuk, M. M., & Zoghbi, H. Y. (1997) · Nature · doi:10.1038/36579 · Cited by 702
Furley, A. J., Brenner‐Morton, S., Manalo, D. J., Karagogeos, D., Dodd, J., & Jessell, T. M. (1990) · Cell · doi:10.1016/0092-8674(90)90223-2 · Cited by 564
Chen, P., Johnson, J. E. B., Zoghbi, H. Y., & Segil, N. (2002) · Development · doi:10.1242/dev.129.10.2495 · Cited by 528
Self-citationGenetic regulation of cerebellar development
Wang, V. Y., & Zoghbi, H. Y. (2001) · Nature reviews. Neuroscience · doi:10.1038/35081558 · Cited by 490
Lo, L., Johnson, J. E. B., Wuenschell, C. W., Saito, T., & Anderson, D. J. (1991) · Genes & Development · doi:10.1101/gad.5.9.1524 · Cited by 435
Self-citationThe regulation of myogenin gene expression during the embryonic development of the mouse.Preprint
Yee, S., & Rigby, P. W. J. (1993) · Genes & Development · doi:10.1101/gad.7.7a.1277 · Cited by 423
Akazawa, C., Ishibashi, M., Shimizu, C., Nakanishi, S., & Kageyama, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.15.8730 · Cited by 357
Proprioceptor Pathway Development Is Dependent on MATH1
Bermingham, N. A., Hassan, B. A., Wang, V. Y., Fernandez, M., Banfi, S., Bellen, H. J., Fritzsch, B., & Zoghbi, H. Y. (2001) · Neuron · doi:10.1016/s0896-6273(01)00305-1 · Cited by 304
Crossinhibitory Activities of Ngn1 and Math1 Allow Specification of Distinct Dorsal Interneurons
Gowan, K., Helms, A. W., Hunsaker, T., Collisson, T., Ebert, P. J., Odom, R., & Johnson, J. E. B. (2001) · Neuron · doi:10.1016/s0896-6273(01)00367-1 · Cited by 302
Self-citationHalata, Z., Grim, M., & Bauman, K. I. (2003) · Anatomical Record Part A-discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.10029 · Cited by 292
Autoregulation and multiple enhancers control Math1 expression in the developing nervous system
Helms, A. W., Abney, A. L., Ben‐Arie, N., Zoghbi, H. Y., & Johnson, J. E. B. (2000) · Development · doi:10.1242/dev.127.6.1185 · Cited by 291
Self-citationProgenitors of dorsal commissural interneurons are defined by MATH1 expression
Helms, A. W., & Johnson, J. E. B. (1998) · Development · doi:10.1242/dev.125.5.919 · Cited by 279
Self-citationFunctional conservation of atonal and Math1 in the CNS and PNS
Ben‐Arie, N., Hassan, B. A., Bermingham, N. A., Malicki, D. M., Armstrong, D. L., Matzuk, M. M., Bellen, H. J., & Zoghbi, H. Y. (2000) · Development · doi:10.1242/dev.127.5.1039 · Cited by 260
Developmental Morphology of the Mouse Inner Ear: A scanning electron microscopic observation
LIM, D. J., & Anniko, M. (1985) · Acta Oto-Laryngologica · doi:10.3109/00016488509121766 · Cited by 247
Airaksinen, M. S., Koltzenburg, M., Lewin, G. R., Masu, Y., Helbig, C., Wolf, E., Brem, G., Toyka, K. V., Thoenen, H., & Meyer, M. (1996) · Neuron · doi:10.1016/s0896-6273(00)80047-1 · Cited by 242
Alder, J., Lee, K. J., Jessell, T. M., & Hatten, M. E. (1999) · Nature Neuroscience · doi:10.1038/9189 · Cited by 223
The Merkel Cell: Recent Findings and Unresolved Problems.
Tachibana, T. (1995) · Archivum histologicum japonicum · doi:10.1679/aohc.58.379 · Cited by 127
Helms, A. W., Gowan, K., Abney, A. L., et al. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0969 · Cited by 69
Self-citationExpression of proneural and neurogenic genes in the embryonic mammalian vestibular system
Shailam, R., Lanford, P. J., Dolinsky, C. M., et al. (1999) · Journal of Neurocytology · doi:10.1023/a:1007009803095 · Cited by 65
Merkel cell distribution in the epidermis as determined by quinacrine fluorescence
Nurse, C. A., Mearow, K. M., Holmes, M., et al. (1983) · Cell and Tissue Research · doi:10.1007/bf00211472 · Cited by 63
Relationship Between Merkel Cells and Nerve Endings During Embryogenesis in the Mouse Epidermis
Pasche‐Koo, F., Mérot, Y., & Saurat, J. ‐. (1990) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12484847 · Cited by 63
Tachibana, T., Yamamoto, H., Takahashi, N., Kamegai, T., Shibanai, S., Iseki, H., & Nawa, T. (1997) · Archivum histologicum japonicum · doi:10.1679/aohc.60.379 · Cited by 50
A fluorescent microscopic study of the development of rat touch domes and their merkel cells
Nurse, C. A., & Diamond, J. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90041-1 · Cited by 49
Sensory innervation of the hairs of the rat hindlimb: A light microscopic analysis
Millard, C., & Woolf, C. J. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902770203 · Cited by 45
Lineage-Specific Regulation of the Neural Differentiation GeneMASH1
Verma‐Kurvari, S., Savage, T. K., Gowan, K., & Johnson, J. E. B. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0332 · Cited by 44
Self-citation
Research works printed but not linked: 1
- Lim, 1985, Developmental morphology of the mouse inner ear, Acta Otolaryngol., 422, 1
Cited by
Sorted by citations
Zuris, J. A., Thompson, D. B., Shu, Y., Guilinger, J. P., Bessen, J. L., Hu, J. H., Maeder, M. L., Joung, J. K., Chen, Z.-Y., & Liu, D. R. (2015) · Nature Biotechnology · doi:10.1038/nbt.3081 · Cited by 1,460
Epidermal Merkel Cells are Mechanosensory Cells that Tune Mammalian Touch Receptors
Maksimovic, S., Nakatani, M., Baba, Y., Nelson, A. M., Marshall, K. L., Wellnitz, S. A., Firozi, P., Woo, S.-H., Ranade, S. S., Patapoutian, A., et al. (2014) · Nature · doi:10.1038/nature13250 · Cited by 524
Self-citationMath1 Is Expressed in Temporally Discrete Pools of Cerebellar Rhombic-Lip Neural Progenitors
Machold, R. P., & Fishell, G. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.028 · Cited by 575
Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents
Gao, X., Tao, Y., Lamas, V., Huang, M., Yeh, W.-H., Pan, B., Hu, Y.-J., Hu, J. H., Thompson, D. B., Shu, Y., et al. (2018) · Nature · doi:10.1038/nature25164 · Cited by 536
Isolation of neural stem cells from the postnatal cerebellum
Lee, A., Kessler, J. D., Read, T., Kaiser, C., Corbeil, D., Huttner, W. Β., Johnson, J. E. B., & Wechsler‐Reya, R. J. (2005) · Nature Neuroscience · doi:10.1038/nn1473 · Cited by 481
Self-citation
Metadata
- Authors
- Lumpkin, E. A., Collisson, T., Parab, P., Omer-Abdalla, A., Haeberle, H., Chen, P., Doetzlhofer, A., White, P., Groves, A., Segil, N., & Johnson, J. E.
- Affiliations
- University of California, San Francisco (US)
- The University of Texas Southwestern Medical Center (US)
- House Clinic (US)
- Corresponding author
- Johnson, Jane E.
- Venue
- Gene Expression Patterns
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 3
- Issue
- 4
- Pages
- 389-395
- ISSN
- 1567-133X (ISSN-L)
- OpenAlex
- W1994624028
- Cited by
- 292
- References
- 30
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 12 · 2023: 17 · 2022: 13 · 2021: 8 · 2020: 11 · 2019: 12 · 2018: 15 · 2017: 13 · 2016: 14 · 2015: 20 · 2014: 18 · 2013: 18 · 2012: 17
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene Expression Patterns (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (R01DC004189)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Keywords
- Math1, bHLH transcription factors, GFP reporter, transgenic mice, neural progenitor cells, dorsal interneurons, granule cell progenitors, cerebellum, Merkel cells, hair cells, vestibular system, auditory system, apical ectodermal ridge, dentate gyrus, retina, olfactory epithelium, brain development
- MeSH terms
- Animals, Cerebellum, Female, Interneurons, Lac Operon, Luminescent Proteins, Mice, Transgenic, Nerve Tissue Proteins, Pregnancy, Skin, Spinal Cord, Transcription Factors, In Situ Hybridization, Gene Expression Regulation, Developmental, Merkel Cells, Green Fluorescent Proteins, Mice, Basic Helix-Loop-Helix Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
