NeuN, a neuronal specific nuclear protein in vertebratesxs
Abstract
A battery of monoclonal antibodies (mAbs) against brain cell nuclei has been generated by repeated immunizations. One of these, mAb A60, recognizes a vertebrate nervous system- and neuron-specific nuclear protein that we have named NeuN (Neuronal Nuclei). The expression of NeuN is observed in most neuronal cell types throughout the nervous system of adult mice. However, some major cell types appear devoid of immunoreactivity including cerebellar Purkinje cells, olfactory bulb mitral cells, and retinal photoreceptor cells. NeuN can also be detected in neurons in primary cerebellar cultures and in retinoic acid-stimulated P19 embryonal carcinoma cells. Immunohistochemically detectable NeuN protein first appears at developmental timepoints which correspond with the withdrawal of the neuron from the cell cycle and/or with the initiation of terminal differentiation of the neuron. NeuN is a soluble nuclear protein, appears as 3 bands (46-48 x 10(3) M(r)) on immunoblots, and binds to DNA in vitro. The mAb crossreacts immunohistochemically with nervous tissue from rats, chicks, humans, and salamanders. This mAb and the protein recognized by it serve as an excellent marker for neurons in the central and peripheral nervous systems in both the embryo and adult, and the protein may be important in the determination of neuronal phenotype.
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Succinate is a unique signaling adaptogenic molecule whose production significantly increases under conditions of ischemia/hypoxia, unlike peptide signaling molecules whose synthesis is blocked by ischemia/hypoxia.
“Therefore, succinate is a unique signaling adaptogenic molecule whose production significantly increases under conditions of ischemia/hypoxia, unlike peptide signaling molecules, whose synthesis is blocked by ischemia/hypoxia [103].”
From Protective Effects of PGC-1α Activators on Ischemic Stroke in a Rat Model of Photochemically Induced Thrombosis (2021) · cites this paper as [103]
Ischemic suppression of translational processes is accompanied by downregulation of peptide neurohormones and neurotransmitters, as well as their receptors.
“The ischemic suppression of translational processes is accompanied by the downregulation of peptide neurohormones and neurotransmitters, as well as their receptors [49,103].”
From Protective Effects of PGC-1α Activators on Ischemic Stroke in a Rat Model of Photochemically Induced Thrombosis (2021) · cites this paper as [103]
NeuN is exclusively expressed in nuclei of most terminally differentiated neurons, with cerebellar Purkinje cells being a notable exception.
“NeuN is exclusively expressed in nuclei of most terminally differentiated neurons, with cerebellar Purkinje cells being a notable exception19.”
From Neuron Enriched Nuclear Proteome Isolated from Human Brain (2013) · cites this paper as [19]
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- Authors
- Mullen, R. J., Buck, C. R., & Smith, A. M.
- Affiliations
- University of Utah (US)
- ORCID
- Smith, Alan M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1992-09-01
- Volume
- 116
- Issue
- 1
- Pages
- 201-211
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2158496649
- Cited by
- 2,351
- References
- 1
- Citations by year
- 2026: 56 · 2025: 61 · 2024: 73 · 2023: 49 · 2022: 60 · 2021: 75 · 2020: 65 · 2019: 68 · 2018: 94 · 2017: 99 · 2016: 103 · 2015: 95 · 2014: 119 · 2013: 119 · 2012: 104
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY07017)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- NeuN, neuronal differentiation, terminal differentiation, cell cycle withdrawal, Purkinje cells, olfactory bulb mitral cells, retinal photoreceptors, P19 embryonal carcinoma cells, DNA binding, neuronal phenotype, brain development, vertebrates
- MeSH terms
- Animals, Antibodies, Monoclonal, Brain, Brain Chemistry, Cell Nucleus, Immunohistochemistry, Nerve Tissue Proteins, Nervous System, Neurons, Nuclear Proteins, Vertebrates, Immunoblotting, Biomarkers
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