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KaKs_Calculator: Calculating Ka and Ks Through Model Selection and Model Averaging

Open access
Zhang, Zhang, Li, Jun, Zhao, Xiao-Qian, Wang, Jun, Wong, Gane Ka-Shu, Yu, Jun·2006·Genomics, Proteomics & Bioinformatics

Abstract

KaKs_Calculator is a software package that calculates nonsynonymous (Ka) and synonymous (Ks) substitution rates through model selection and model averaging. Since existing methods for this estimation adopt their specific mutation (substitution) models that consider different evolutionary features, leading to diverse estimates, KaKs_Calculator implements a set of candidate models in a maximum likelihood framework and adopts the Akaike information criterion to measure fitness between models and data, aiming to include as many features as needed for accurately capturing evolutionary information in protein-coding sequences. In addition, several existing methods for calculating Ka and Ks are also incorporated into this software. KaKs_Calculator, including source codes, compiled executables, and documentation, is freely available for academic use at http://evolution.genomics.org.cn/software.htm.

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Metadata

Authors
Zhang, Z., Li, J., Zhao, X.-Q., Wang, J., Wong, G. K.-S., & Yu, J.
Venue
Genomics, Proteomics & Bioinformatics
Published
2006-12-01
Volume
4
Issue
4
Pages
259-263
ISSN
  • 1672-0229 (ISSN-L)
  • 2210-3244
OpenAlex
W2003062832
Cited by
1,231
References
7
FWCI
2.09
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: KaKs_Calculator: Calculating Ka and Ks Through Model Selection and Model Averaging. https://app.cochat.ai/papers/10.1016/s1672-0229(07)60007-2
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Zhang, Z., Li, J., Zhao, X.-Q., Wang, J., Wong, G. K.-S., & Yu, J. (2006). KaKs_Calculator: Calculating Ka and Ks Through Model Selection and Model Averaging. Genomics, Proteomics & Bioinformatics. https://doi.org/10.1016/s1672-0229(07)60007-2

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