A codon-based model of nucleotide substitution for protein-coding DNA sequences.
Abstract
A codon-based model for the evolution of protein-coding DNA sequences is presented for use in phylogenetic estimation. A Markov process is used to describe substitutions between codons. Transition/transversion rate bias and codon usage bias are allowed in the model, and selective restraints at the protein level are accommodated using physicochemical distances between the amino acids coded for by the codons. Analyses of two data sets suggest that the new codon-based model can provide a better fit to data than can nucleotide-based models and can produce more reliable estimates of certain biologically important measures such as the transition/transversion rate ratio and the synonymous/nonsynonymous substitution rate ratio.
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The first codon models estimated parameters representing an averaged nonsynonymous-synonymous rate ratio.
“The first codon models estimated parameters representing an averaged nonsynonymous-synonymous rate ratio.”
From RELAX: Detecting Relaxed Selection in a Phylogenetic Framework (2015) · cites this paper as Goldman and Yang 1994
Cites
Kimura, M. (1980) · Journal of Molecular Evolution · doi:10.1007/bf01731581 · Cited by 29,778 · see citing works
Evolutionary trees from DNA sequences: A maximum likelihood approach.
Felsenstein, J. (1981) · Journal of Molecular Evolution · doi:10.1007/bf01734359 · Cited by 14,571 · see citing works
Evolution of Protein Molecules
JUKES, T. H., & CANTOR, C. R. (1969) · Mammalian Protein Metabolism · doi:10.1016/b978-1-4832-3211-9.50009-7 · Cited by 11,032 · see citing works
Dating of the human–ape splitting by a molecular clock of mitochondrial DNA.
Hasegawa, M., Kishino, H., & Yano, T.-A. (1985) · Journal of Molecular Evolution · doi:10.1007/bf02101694 · Cited by 8,687 · see citing works
Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.
Nei, M., & Gojobori, T. (1986) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040410 · Cited by 4,904 · see citing works
<i>The Theory of Stochastic Processes</i>
Cox, D. R., Miller, H. D., Weiss, G., & Shuler, K. (1966) · Physics Today · doi:10.1063/1.3047872 · Cited by 3,324 · see citing works
Amino Acid Difference Formula to Help Explain Protein Evolution
Grantham, R. L. (1974) · Science · doi:10.1126/science.185.4154.862 · Cited by 2,363 · see citing works
Mitochondrial DNA sequences of primates: tempo and mode of evolution
Brown, W. M., Prager, E. M., Wang, A., & Wilson, A. C. (1982) · Journal of Molecular Evolution · doi:10.1007/bf01734101 · Cited by 1,554 · see citing works
Unbiased estimation of the rates of synonymous and nonsynonymous substitution
Li, W. (1993) · Journal of Molecular Evolution · doi:10.1007/bf02407308 · Cited by 1,088 · see citing works
Estimating the pattern of nucleotide substitution
Yang, Z. (1994) · Journal of Molecular Evolution · doi:10.1007/bf00178256 · Cited by 1,076 · see citing works
Self-citationLi, W., Wu, C., & Luo, C. C. (1985) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040343 · Cited by 1,053 · see citing works
Yang, Z. (1993) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040082 · Cited by 1,040 · see citing works
Self-citationMaximum likelihood inference of protein phylogeny and the origin of chloroplasts
Kishino, H., Miyata, T., & Hasegawa, M. (1990) · Journal of Molecular Evolution · doi:10.1007/bf02109483 · Cited by 887 · see citing works
Evolution of the Zfx and Zfy genes: rates and interdependence between the genes.
Pamilo, P., & Bianchi, N. O. (1993) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040003 · Cited by 505 · see citing works
An evolutionary model for maximum likelihood alignment of DNA sequences
Thorne, J. L., Kishino, H., & Felsenstein, J. (1991) · Journal of Molecular Evolution · doi:10.1007/bf02193625 · Cited by 445 · see citing works
Comparison of models for nucleotide substitution used in maximum-likelihood phylogenetic estimation.
Yang, Z., Goldman, N., & Friday, A. (1994) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040112 · Cited by 433 · see citing works
Self-citationMiyata, T., & Yasunaga, T. (1980) · Journal of Molecular Evolution · doi:10.1007/bf01732067 · Cited by 411 · see citing works
Inching toward reality: An improved likelihood model of sequence evolution
Thorne, J. L., Kishino, H., & Felsenstein, J. (1992) · Journal of Molecular Evolution · doi:10.1007/bf00163848 · Cited by 329 · see citing works
Overington, J. P., Donnelly, D., Johnson, M. S., Šali, A., & Blundell, T. L. (1992) · Protein Science · doi:10.1002/pro.5560010203 · Cited by 304 · see citing works
Comparison of proteins of ADP-glucose pyrophosphorylase from diverse sources
Smith-White, B. J., & Preiss, J. (1992) · Journal of Molecular Evolution · doi:10.1007/bf00162999 · Cited by 203 · see citing works
Reeves, J. H. (1992) · Journal of Molecular Evolution · doi:10.1007/bf00160257 · Cited by 147 · see citing works
Evolutionary Analysis of Plant DNA Sequences
Ritland, K., & Clegg, M. T. (1987) · The American Naturalist · doi:10.1086/284693 · Cited by 128 · see citing works
Simple diagnostic statistical tests of models for DNA substitution
Goldman, N. (1993) · Journal of Molecular Evolution · doi:10.1007/bf00182751 · Cited by 126 · see citing works
Self-citationThe consistency of several phylogeny-inference methods under varying evolutionary rates.
DeBry, R. W. (1992) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040740 · Cited by 105 · see citing works
Inferring the number of evolutionary events from DNA coding sequence differences.
Lewontin, R. C. (1989) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040532 · Cited by 87 · see citing works
Reflections on higher mammalian phylogenetics
Novacek, M. J. (1993) · Journal of Mammalian Evolution · doi:10.1007/bf01027597 · Cited by 55 · see citing works
Navidi, W. C., Churchill, G. A., & von Haeseler, A. (1991) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040633 · Cited by 52 · see citing works
Deriving an Amino Acid Distance Matrix
Taylor, W. R., & Jones, D. T. (1993) · Journal of Theoretical Biology · doi:10.1006/jtbi.1993.1140 · Cited by 36 · see citing works
A template based method of pattern matching in protein sequences
Taylor, W. R. (1989) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(89)90011-4 · Cited by 20 · see citing works
Neighbor-Joining Uses the Optimal Weight for Net Divergence
Charleston, M., Hendy, M. D., & Penny, D. (1993) · Molecular Phylogenetics and Evolution · doi:10.1006/mpev.1993.1002 · Cited by 12 · see citing works
Stochastic traits of molecular evolution—Acceptance of point mutations in native actin genes
Schöniger, M., Hofacker, G. L., & Borštnik, B. (1990) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(05)80031-1 · Cited by 11 · see citing works
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Drummond, A. J., & Rambaut, A. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-214 · Cited by 12,898 · see citing works
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Yang, Z. (1997) · Computer applications in the biosciences · doi:10.1093/bioinformatics/13.5.555 · Cited by 5,344 · see citing works
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Bouckaert, R., Vaughan, T. G., Barido-Sottani, J., Duchêne, S., Fourment, M., Gavryushkina, A., Heled, J., Jones, G., Kühnert, D., De Maio, N., et al. (2019) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1006650 · Cited by 4,556 · see citing works
PAL2NAL: robust conversion of protein sequence alignments into the corresponding codon alignments
Suyama, M., Torrents, D., & Bork, P. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl315 · Cited by 3,270 · see citing works
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Greenman, C. D., Stephens, P., Smith, R., Dalgliesh, G. L., Hunter, C., Bignell, G. R., Davies, H. R., Teague, J. W., Butler, A. P., Stevens, C., et al. (2007) · Nature · doi:10.1038/nature05610 · Cited by 3,062 · see citing works
Not So Different After All: A Comparison of Methods for Detecting Amino Acid Sites Under Selection
Pond, S. L. K., & Frost, S. D. W. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msi105 · Cited by 2,320 · see citing works
Bayes Empirical Bayes Inference of Amino Acid Sites Under Positive Selection
Yang, Z. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msi097 · Cited by 2,304 · see citing works
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Yang, Z., Nielsen, R., Goldman, N., & Pedersen, A.-M. K. (2000) · Genetics · doi:10.1093/genetics/155.1.431 · Cited by 2,286 · see citing works
Self-citationAncestral polyploidy in seed plants and angiosperms
Jiao, Y., Wickett, N. J., Ayyampalayam, S., Chanderbali, A. S., Landherr, L. L., Ralph, P. E., Tomsho, L. P., Hu, Y., Liang, H., Soltis, P. S., et al. (2011) · Nature · doi:10.1038/nature09916 · Cited by 2,224 · see citing works
Statistical tests of selective neutrality in the age of genomics
Nielsen, R. (2001) · Heredity · doi:10.1046/j.1365-2540.2001.00895.x · Cited by 1,905 · see citing works
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Murrell, B., Wertheim, J. O., Moola, S., Weighill, T., Scheffler, K., & Kosakovsky Pond, S. L. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002764 · Cited by 1,811 · see citing works
Statistical methods for detecting molecular adaptation
Yang, Z., & Bielawski, J. P. (2000) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(00)01994-7 · Cited by 1,788 · see citing works
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Martincorena, I., Roshan, A., Gerstung, M., Ellis, P., Van Loo, P., McLaren, S., Wedge, D. C., Fullam, A., Alexandrov, L. B., Tubio, J. M., et al. (2015) · Science · doi:10.1126/science.aaa6806 · Cited by 1,770 · see citing works
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Yang, Z. (1998) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a025957 · Cited by 1,446 · see citing works
Self-citationEvolutionary and biomedical insights from the rhesus macaque genome.
Gibbs, R. A., Rogers, J., Katze, M. G., Bumgarner, R., Weinstock, G. M., Mardis, E. R., Remington, K. A., Strausberg, R. L., Venter, J. C., Wilson, R. K., et al. (2007) · Science · doi:10.1126/science.1139247 · Cited by 1,403 · see citing works
Yang, Z., & Nielsen, R. (2002) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a004148 · Cited by 1,374 · see citing works
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KaKs_Calculator: Calculating Ka and Ks Through Model Selection and Model Averaging
Zhang, Z., Li, J., Zhao, X., Wang, J., Wong, G. K., & Yu, J. M. (2006) · Genomics Proteomics & Bioinformatics · doi:10.1016/s1672-0229(07)60007-2 · Cited by 1,227 · see citing works
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Yang, Z. (2006) · doi:10.1093/acprof:oso/9780198567028.001.0001 · Cited by 1,143 · see citing works
Self-citationFunctional Divergence of Duplicated Genes Formed by Polyploidy during Arabidopsis Evolution[W]
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Phylogeny Estimation and Hypothesis Testing Using Maximum Likelihood
Huelsenbeck, J. P., & Crandall, K. A. (1997) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.ecolsys.28.1.437 · Cited by 1,018 · see citing works
PhyloCSF: a comparative genomics method to distinguish protein coding and non-coding regionsPreprint
Lin, M. F., Jungreis, I., & Kellis, M. (2010) · Nature Precedings · doi:10.1093/bioinformatics/btr209 · Cited by 1,009 · see citing works
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Maere, S., Bodt, S. D., Raes, J., Casneuf, T., MONTAGU, M. V., Kuiper, M. T. R., & de Peer, Y. V. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501102102 · Cited by 917 · see citing works
A new Voronoi-based surface reconstruction algorithm
Amenta, N., Bern, M. W., & Kamvysselis, M. (1998) · ACM SIGGRAPH Conference (SIGGRAPH) · doi:10.1145/280814.280947 · Cited by 916 · see citing works
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Argout, X., Salse, J., Aury, J., Guiltinan, M. J., Droc, G., Gouzy, J., Allègre, M., Chaparro, C., Legavre, T., Maximova, S. N., et al. (2010) · Nature Genetics · doi:10.1038/ng.736 · Cited by 746 · see citing works
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Blanc, G., Hokamp, K., & Wolfe, K. H. (2003) · Genome Research · doi:10.1101/gr.751803 · Cited by 724 · see citing works
Genome analysis of the platypus reveals unique signatures of evolution
paper, A. L. O. A. A. T. A. A. A. T. E. O. T. (2008) · Nature · doi:10.1038/nature06936 · Cited by 719 · see citing works
Brandley, M. C., Schmitz, A., & Reeder, T. W. (2005) · Systematic Biology · doi:10.1080/10635150590946808 · Cited by 688 · see citing works
Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human
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Synonymous and nonsynonymous rate variation in nuclear genes of mammals
Yang, Z., & Nielsen, R. (1998) · Journal of Molecular Evolution · doi:10.1007/pl00006320 · Cited by 640 · see citing works
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MOLPHY version 2.3 : programs for molecular phylogenetics based on maximum likelihood
Adachi, J. (1996) · Cited by 605 · see citing works
Wong, W. S. W., Yang, Z., Goldman, N., & Nielsen, R. (2004) · Genetics · doi:10.1534/genetics.104.031153 · Cited by 595 · see citing works
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An integrated view of protein evolution
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Nei, M. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msi242 · Cited by 412 · see citing works
Allio, R., Donegà, S., Galtier, N., & Nabholz, B. (2017) · Molecular Biology and Evolution · doi:10.1093/molbev/msx197 · Cited by 412 · see citing works
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Ku, H., Vision, T., Liu, J., & Tanksley, S. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160271297 · Cited by 402 · see citing works
A random effects branch-site model for detecting episodic diversifying selection
Kosakovsky Pond, S. L., Murrell, B., Fourment, M., Frost, S. D. W., Delport, W., & Scheffler, K. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr125 · Cited by 400 · see citing works
Evidence for Variable Selective Pressures at MC1R
Harding, R. M., Healy, E., Ray, A. J., Ellis, N. S., Flanagan, N., Todd, C., Dixon, C., Sajantila, A., Jackson, I. J., Birch-Machin, M. A., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/302863 · Cited by 389 · see citing works
Yang, Z., & Swanson, W. J. (2002) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a003981 · Cited by 380 · see citing works
Self-citationPhylogenetic Estimation of Context-Dependent Substitution Rates by Maximum Likelihood
Siepel, A. C. (2003) · Molecular Biology and Evolution · doi:10.1093/molbev/msh039 · Cited by 375 · see citing works
Probability Models for DNA Sequence Evolution
Durrett, R. (2002) · Probability and its applications · doi:10.1007/978-1-4757-6285-3 · Cited by 366 · see citing works
Bañuls, A., Hidé, M., & Prugnolle, F. (2007) · Advances in Parasitology/Advances in parasitology · doi:10.1016/s0065-308x(06)64001-3 · Cited by 362 · see citing works
Comparative transcriptomics reveals patterns of selection in domesticated and wild tomato
Koenig, D., Jiménez‐Gómez, J. M., Kimura, S., Fulop, D., Chitwood, D. H., Headland, L. R., Kumar, R. S., Covington, M. F., Devisetty, U. K., Tat, A. V., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309606110 · Cited by 362 · see citing works
Yang, Z., & Yoder, A. D. (2003) · Systematic Biology · doi:10.1080/10635150390235557 · Cited by 357 · see citing works
Self-citationEvolution of reproductive proteins from animals and plants
Clark, N. L., Aagaard, J. E., & Swanson, W. J. (2005) · Reproduction · doi:10.1530/rep.1.00357 · Cited by 357 · see citing works
The importance of proper model assumption in bayesian phylogenetics.
Lemmon, A. R., & Moriarty, E. C. (2004) · Systematic Biology · doi:10.1080/10635150490423520 · Cited by 356 · see citing works
Empirical and Hierarchical Bayesian Estimation of Ancestral States
Huelsenbeck, J. P., & Bollback, J. P. (2001) · Systematic Biology · doi:10.1080/10635150119871 · Cited by 356 · see citing works
Sperm wars and the evolution of male fertility
Simmons, L. W., & Fitzpatrick, J. L. (2012) · Reproduction · doi:10.1530/rep-12-0285 · Cited by 344 · see citing works
Barker, M. S., Kane, N. C., Matvienko, M., Kozik, A., Michelmore, R. W., Knapp, S. J., & Rieseberg, L. H. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn187 · Cited by 342 · see citing works
Mining EST databases to resolve evolutionary events in major crop species
Schlueter, J. A., Dixon, P. M., Granger, C. L., Grant, D., Clark, L. G., Doyle, J. J., & Shoemaker, R. C. (2004) · Genome · doi:10.1139/g04-047 · Cited by 338 · see citing works
Evolution of Arabidopsis microRNA families through duplication eventsPreprint
Maher, C. A., Stein, L. D., & Ware, D. (2006) · Genome Research · doi:10.1101/gr.4680506 · Cited by 334 · see citing works
Stern, A., Doron‐Faigenboim, A., Erez, E., Martz, E., Bacharach, E., & Pupko, T. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm382 · Cited by 331 · see citing works
Yang, Z., & Nielsen, R. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msm284 · Cited by 331 · see citing works
Self-citationLegume genome evolution viewed through the Medicago truncatula and Lotus japonicus genomes
Cannon, S. B., Sterck, L., Rombauts, S., Sato, S., Cheung, F., Gouzy, J., Wang, X., Mudge, J., Vasdewani, J., Schiex, T., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603228103 · Cited by 330 · see citing works
Evolution of the chicken Toll-like receptor gene family: A story of gene gain and gene loss
Temperley, N. D., Berlin, S., Paton, I. R., Griffin, D. K., & Burt, D. W. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-62 · Cited by 327 · see citing works
Marshall, R., Kombrink, A., Motteram, J., Loza‐Reyes, E., Lucas, J. A., Hammond-Kosack, K. E., Thomma, B. P. H. J., & Rudd, J. J. (2011) · PLANT PHYSIOLOGY · doi:10.1104/pp.111.176347 · Cited by 326 · see citing works
Evolutionary distances for protein-coding sequences: modeling site- specific residue frequencies
Halpern, A. L., & Bruno, W. (1998) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a025995 · Cited by 324 · see citing works
Nekrutenko, A., Makova, K. D., & Li, W. (2001) · Genome Research · doi:10.1101/gr.200901 · Cited by 324 · see citing works
Causes of evolutionary rate variation among protein sites
Echave, J., Spielman, S. J., & Wilke, C. O. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2015.18 · Cited by 323 · see citing works
Phylogenetic systematics turns over a new leaf
Lewis, P. O. (2001) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(00)02025-5 · Cited by 320 · see citing works
- Authors
- Goldman, N., & Yang, Z.
- Affiliations
- National Institute for Medical Research (GB)
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-09
- Volume
- 11
- Issue
- 5
- Pages
- 725-36
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W1920973730
- Cited by
- 1,960
- References
- 31
- Citations by year
- 2026: 18 · 2025: 42 · 2024: 51 · 2023: 43 · 2022: 61 · 2021: 65 · 2020: 60 · 2019: 74 · 2018: 71 · 2017: 60 · 2016: 69 · 2015: 68 · 2014: 107 · 2013: 97 · 2012: 89
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Biology and Evolution (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- Markov processes, codon usage bias, selective constraint, synonymous substitution rate, nonsynonymous substitution rate, phylogenetic estimation, nucleotide substitution models
- MeSH terms
- Animals, Chemistry, Physical, Codon, DNA, Genes, Globins, Mammals, Markov Chains, Models, Genetic, Nucleotidyltransferases, Phylogeny, Proteins, Likelihood Functions, Point Mutation, Glucose-1-Phosphate Adenylyltransferase, Chemical Phenomena
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