Determinants of quality of life in ovarian cancer survivors: a pilot study
Open accessAbstract
Objective Ovarian cancer treatments and outcomes vary substantially, yielding a diverse group of survivors. Few data exist on quality of life (QoL) concerns and the foremost needs of these patients. Our goal was to conduct a pilot study to determine the QoL needs of ovarian cancer survivors to establish priorities for future interventions.Methods In this cross-sectional study, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaires (EORTC QLQ-C30 and OV28) QoL questionnaires and one investigator-derived questionnaire were administered in an outpatient setting. Clinical parameters were abstracted and tested for associations with QoL measures.Results A total of 102 women consented to participate and completed all components. Their mean age was 58 years (range 29 to 85), with 80% having epithelial ovarian carcinoma and 66% high-grade serous carcinoma. Women with stage I (28%), II (15%), III (47%), and IV (10%) lesions were represented in the primary treatment (25%), surveillance (46%), recurrent (23%), and palliative (7%) phases of the survivorship continuum. Fifty-one percent characterized their disease burden as "quite a bit" or "very much," and this did not vary by histology or diagnoses. Global QoL did not vary by clinico-pathologic parameters. Cardiovascular and respiratory comorbidities were associated with EORTC scores in physical functioning (P=0.027 for cardiovascular and P=0.041 for respiratory), global QoL (P=0.03 for cardiovascular and P=0.039 for respiratory), and sexual health (P=0.025 for cardiovascular). Task completion/memory/concentration, anxiety, and fatigue were the distress categories given highest priority by respondents.Conclusion In women with ovarian cancer, clinical factors such as age, stage, and histology did not have a significant impact on QoL. Psychosocial factors have a larger impact on global QoL than physical symptoms.
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Ovarian cancer survivors often have long-term symptoms such as anxiety, depression, sleep problems, fatigue, physical symptoms, reduced health-related quality of life, and a poor outlook.
“Ovarian cancer (OC) survivors commonly experience chronic symptoms including anxiety, depression, sleep disturbances, fatigue, physical symptoms, poor health-related quality of life (HRQOL), and a generally poor prognosis.”
From Living Well: Protocol for a web-based program to improve quality of life in rural and urban ovarian cancer survivors (2024) · cites this paper as [9]
The Results (page unavailable) report anxiety, insomnia, fatigue, pain and other physical symptoms as quality-of-life concerns among the ovarian cancer survivors studied. They do not establish that these symptoms are chronic or that depression is a common symptom; depression appears only as a possible pre-existing diagnosis in Materials and Methods. The introduction describes prognoses as ranging widely, rather than survivors having a generally poor prognosis. (LLM, conf=0.87)
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Pennington, K. P., Schlumbrecht, M., McGregor, B. A., Goodheart, M. J., Heron, L., Zimmerman, B., Telles, R., Zia, S., Penedo, F. J., & Lutgendorf, S. K. (2024) · Contemporary Clinical Trials · doi:10.1016/j.cct.2024.107612 · Cited by 3 · see citing works
- Authors
- Teng, F. F., Kalloger, S. E., Brotto, L., & McAlpine, J. N.
- Affiliations
- University of British Columbia (CA)
- Venue
- Journal of Obstetrics and Gynaecology Canada
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 36
- Issue
- 8
- Pages
- 708-715
- ISSN
- 1701-2163 (ISSN-L)
- OpenAlex
- W2189330448
- Cited by
- 42
- References
- 45
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 3
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Obstetrics and Gynaecology Canada (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ovarian Cancer Canada
- BC Cancer Agency
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Keywords
- ovarian cancer survivors, quality of life, EORTC QLQ-C30, high-grade serous carcinoma, epithelial ovarian cancer, comorbidities, physical function, sexual health, fatigue, anxiety, psychosocial factors, patient needs
- MeSH terms
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Cross-Sectional Studies, Female, Humans, Middle Aged, Ovarian Neoplasms, Pilot Projects, Quality of Life, Survivors
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