Lipid-lowering effects of oleanolic acid in hyperlipidemic patients
Abstract
Oleanolic acid (OA) is a pentacyclic triterpenoid compound extracted from olea europaeal, a traditional Chinese medicine herb. OA has been used in the clinic as a hepatoprotective medicine in China since 1970s. In our previous study, we observed that OA could ameliorate hyperlipidemia in animal models. In the present study, we conducted a small-scale clinical trial to evaluate the hypolipidemia effect of OA in hyperlipidemic patients. Hyperlipidemic patients were administrated with OA for four weeks (4 tablets once, three times a day). The blood samples of the patients were collected before and after OA treatment. The biological parameters were measured. Furthermore, three patients' blood samples were studied with DNA microarray. After OA administration, the TC, TG, and HDLC levels in serum decreased significantly. DNA microarray analysis results showed that the expressions of 21 mRNAs were significantly changed after OA treatment. Bioinformatics analysis showed 17 mRNAs were up-regulated and 4 mRNAs were down-regulated significantly after OA treatment. Five mRNAs (CACNA1B, FCN, STEAP3, AMPH, and NR6A1) were selected to validate the expression levels by qRT-PCR. Therefore, OA administration differentially regulated the expression of genes involved in lipid metabolism. The data showed a clinical evidence that OA could improve hyperlipidemia and also unveiled a new insight into the molecular mechanisms underlying the pharmacological effect of OA on hyperlipidemia.
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Research on the health effects of OPO in humans is limited to assessment of some pure minor components administered as drugs or food supplements or as functional VOO enriched in some triterpenes.
“However, research on the health effects of OPO in humans is limited to the assessment of some pure minor components administered as drugs or food supplements [10–12] or as functional VOO enriched in some triterpenes [13, 14], yet to this date the effect of consuming OPO in the diet has not been studied.”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [11]
To this date, the effect of consuming OPO in the diet has not been studied.
“However, research on the health effects of OPO in humans is limited to the assessment of some pure minor components administered as drugs or food supplements [10–12] or as functional VOO enriched in some triterpenes [13, 14], yet to this date the effect of consuming OPO in the diet has not been studied.”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [11]
Most evidence on the potential health beneficial effects of olive minor components comes from in vitro studies or preclinical animal studies, while clinical studies in humans on the cardiometabolic effects of these compounds are scarce and limited to the use of pure components as drug therapy or dietary supplements.
“Most of the evidence on the potential health beneficial effects of olive minor components come from in vitro studies in different cell models or from preclinical animal studies [reviewed in 6]. However, clinical studies in humans on the cardiometabolic effects of these compounds are scarce, limited to the use of pure components such as squalene or triterpenic acids as drug therapy or dietary suppl”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [11]
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References 22 · Cited by 44
- Authors
- LUO, H.-Q., SHEN, J., CHEN, C.-P., MA, X., LIN, C., OUYANG, Q., XUAN, C.-X., LIU, J., SUN, H.-B., & LIU, J.
- Affiliations
- Jiangsu Province Hospital (CN)
- China Pharmaceutical University (CN)
- Corresponding author
- LIU, Jun
- Venue
- Chinese Journal of Natural Medicines
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 16
- Issue
- 5
- Pages
- 339-346
- ISSN
- 1672-3651 (ISSN-L)
- 1875-5364
- OpenAlex
- W2805488580
- Cited by
- 44
- References
- 22
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 11 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 1
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chinese Journal of Natural Medicines (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (Nos. 81673443, 81373303 and 31501182)
- Fundamental Research Funds for the Central Universities (No. 26302017ZD05)
- Topics
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- oleanolic acid, hyperlipidemia, hypolipidemic effect, lipid metabolism, triterpenoids, Olea europaea, serum cholesterol, triglycerides, HDL cholesterol, gene expression profiling, CACNA1B, fully convolutional network, STEAP3, NR6A1, hepatoprotective plants
- MeSH terms
- China, Drugs, Chinese Herbal, Female, Gene Expression Regulation, Humans, Hyperlipidemias, Male, Middle Aged, Oleanolic Acid, RNA, Messenger, Treatment Outcome, Computational Biology, Gene Expression Profiling, Lipid Metabolism
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