Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: A meta-analysis of individual participant data.
Open accessAbstract
Background Neuraminidase inhibitors were widely used during the 2009-10 influenza A H1N1 pandemic, but evidence for their effectiveness in reducing mortality is uncertain. We did a meta-analysis of individual participant data to investigate the association between use of neuraminidase inhibitors and mortality in patients admitted to hospital with pandemic influenza A H1N1pdm09 virus infection.Methods We assembled data for patients (all ages) admitted to hospital worldwide with laboratory confirmed or clinically diagnosed pandemic influenza A H1N1pdm09 virus infection. We identified potential data contributors from an earlier systematic review of reported studies addressing the same research question. In our systematic review, eligible studies were done between March 1, 2009 (Mexico), or April 1, 2009 (rest of the world), until the WHO declaration of the end of the pandemic (Aug 10, 2010); however, we continued to receive data up to March 14, 2011, from ongoing studies. We did a meta-analysis of individual participant data to assess the association between neuraminidase inhibitor treatment and mortality (primary outcome), adjusting for both treatment propensity and potential confounders, using generalised linear mixed modelling. We assessed the association with time to treatment using time-dependent Cox regression shared frailty modelling.Findings We included data for 29,234 patients from 78 studies of patients admitted to hospital between Jan 2, 2009, and March 14, 2011. Compared with no treatment, neuraminidase inhibitor treatment (irrespective of timing) was associated with a reduction in mortality risk (adjusted odds ratio [OR] 0·81; 95% CI 0·70-0·93; p=0·0024). Compared with later treatment, early treatment (within 2 days of symptom onset) was associated with a reduction in mortality risk (adjusted OR 0·48; 95% CI 0·41-0·56; p<0·0001). Early treatment versus no treatment was also associated with a reduction in mortality (adjusted OR 0·50; 95% CI 0·37-0·67; p<0·0001). These associations with reduced mortality risk were less pronounced and not significant in children. There was an increase in the mortality hazard rate with each day's delay in initiation of treatment up to day 5 as compared with treatment initiated within 2 days of symptom onset (adjusted hazard ratio [HR 1·23] [95% CI 1·18-1·28]; p<0·0001 for the increasing HR with each day's delay).Interpretation We advocate early instigation of neuraminidase inhibitor treatment in adults admitted to hospital with suspected or proven influenza infection.Funding F Hoffmann-La Roche.
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The undesirable effects associated with unnecessary MRSA coverage are supported by studies showing an association between early discontinuation of MRSA coverage and better outcomes in patients with negative nares or bronchoalveolar lavage (BAL) MRSA PCR.
“The undesirable effects associated with unnecessary MRSA coverage are also supported by studies showing an association between early discontinuation of MRSA coverage and better outcomes in patients with negative nares or bronchoalveolar lavage (BAL) MRSA PCR (157-159).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [159]
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Experimental — accuracy not yet measuredThere appears to be no overall effect of neuraminidase inhibitors on mortality in patients with influenza-related pneumonia, but there may be an effect when administered early.
“While there appears to be no overall effect of neuraminidase inhibitors on mortality in patients with influenza-related pneumonia, there may be an effect when administered early in the course of the disease [225].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [225]
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Cites
Meta-analysis of individual participant data: rationale, conduct, and reporting
Riley, R. D., Lambert, P. C., & Abo-Zaid, G. (2010) · BMJ · doi:10.1136/bmj.c221 · Cited by 1,701 · see citing works
The Propensity Score with Continuous Treatments
Hirano, K., & Imbens, G. W. (2004) · Wiley Series in Probability and Statistics · doi:10.1002/0470090456.ch7 · Cited by 1,064 · see citing works
Harder, V. S., Stuart, E. A., & Anthony, J. C. (2010) · Psychological Methods · doi:10.1037/a0019623 · Cited by 802 · see citing works
Kerkhove, M. D. V., Vandemaele, K., Shinde, V., Jaramillo-Gutierrez, G., Koukounari, A., Donnelly, C. A., Carlino, L. O., Owen, R., Paterson, B., Pelletier, L., et al. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001053 · Cited by 707 · see citing works
Self-citationAntiviral Therapy and Outcomes of Influenza Requiring Hospitalization in Ontario, Canada
McGeer, A., Green, K. A., Plevneshi, A., Shigayeva, A., Siddiqi, N., Raboud, J., Low, D. E., & Toronto Invasive Bacterial Diseases Network (2007) · Clinical Infectious Diseases · doi:10.1086/523584 · Cited by 398 · see citing works
Self-citationNichols, W. G., Guthrie, K. A., Corey, L., & Boeckh, M. (2004) · Clinical Infectious Diseases · doi:10.1086/425004 · Cited by 376 · see citing works
Chemaly, R. F., Ghosh, S., Bodey, G. P., Rohatgi, N., Safdar, A., Keating, M. J., Champlin, R. E., Aguilera, E. A., Tarrand, J. J., & RAAD, I. I. (2006) · Medicine · doi:10.1097/01.md.0000232560.22098.4e · Cited by 329 · see citing works
Antivirals for Treatment of Influenza
Hsu, J., Santesso, N. A., Mustafa, R. A., Brożek, J., Chen, Y. L., Hopkins, J. P., Cheung, A., Hovhannisyan, G., Ivanova, L., Flottorp, S. A., et al. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-156-7-201204030-00411 · Cited by 306 · see citing works
Self-citationOutcomes of adults hospitalised with severe influenza
Lee, N. L. S., Choi, K. W. Y., Chan, P. K. S., Hui, D. S. C., Lui, G. C.-Y., Wong, B. C. K., Wong, R. Y. K., Sin, W. Y., Hui, W. M., Ngai, K. L. K., et al. (2010) · Thorax · doi:10.1136/thx.2009.130799 · Cited by 209 · see citing works
Muthuri, S. G., Myles, P. R., Venkatesan, S., Leonardi‐Bee, J., & Nguyen‐Van‐Tam, J. S. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis726 · Cited by 193 · see citing works
Self-citationConfounding by Indication in Epidemiologic Studies of Commonly Used Analgesics
Signorello, L. B., McLaughlin, J. K., Lipworth, L., Friis, S. R., Sørensen, H. T., & Blot, W. J. (2002) · American Journal of Therapeutics · doi:10.1097/00045391-200205000-00005 · Cited by 178 · see citing works
Adisasmito, W. B. B., Chan, P. K. S., Lee, N. L. S., et al. (2010) · The Journal of Infectious Diseases · doi:10.1086/656316 · Cited by 161 · see citing works
Applied Bayesian Modeling And Causal Inference From Incomplete-Data Perspectives
Gelman, A., & Xiaoli, M. (2014) · Cited by 152 · see citing works
Li, C., Wang, L., Eng, H., You, H., Chang, L., Tang, K.-S., Lin, Y.-J., Kuo, H.-C., Lee, I., Liu, J.-W., et al. (2010) · Emerging infectious diseases · doi:10.3201/eid1608.091918 · Cited by 144 · see citing works
Hanshaoworakul, W., Simmerman, J. M., Narueponjirakul, U., Sanasuttipun, W., Shinde, V., Kaewchana, S., Areechokechai, D., Levy, J., & Ungchusak, K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006051 · Cited by 142 · see citing works
Case Fatality Risk of Influenza A (H1N1pdm09)
Wong, J. Y., Kelly, H. A., Ip, D., Wu, J. T. K., Leung, G. M., & Cowling, B. J. (2013) · Epidemiology · doi:10.1097/ede.0b013e3182a67448 · Cited by 115 · see citing works
Oseltamivir Pharmacokinetics, Dosing, and Resistance Among Children Aged <2 Years With Influenza
Kimberlin, D. W., Acosta, E. P., Prichard, M. N., Sánchez, P. J., Ampofo, K., Lang, D. J., Ashouri, N., Vanchiere, J. A., Abzug, M. J., Abughali, N., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis765 · Cited by 87 · see citing works
Myles, P. R., Semple, M. G., Lim, W. S., Openshaw, P. J. M., Gadd, E. M., Read, R. C., Taylor, B. L., Brett, S. J., McMenamin, J., Enstone, J. E., et al. (2012) · Thorax · doi:10.1136/thoraxjnl-2011-200266 · Cited by 82 · see citing works
Self-citationTransmission dynamics and impact of pandemic influenza A (H1N1) 2009 virus.
(2009) · PubMed · Cited by 77 · see citing works
Determinants of Antiviral Effectiveness in Influenza Virus A Subtype H5N1
Chan, P. K. S., Lee, N. L. S., Zaman, M., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis509 · Cited by 75 · see citing works
Widespread use of neuraminidase inhibitors in Japan
Sugaya, N. (2011) · Journal of Infection and Chemotherapy · doi:10.1007/s10156-011-0288-0 · Cited by 74 · see citing works
Neuraminidase Inhibitors for Critically Ill Children With Influenza
Louie, J. K., Yang, S., Samuel, M. C., Uyeki, T. M., & Schechter, R. (2013) · PEDIATRICS · doi:10.1542/peds.2013-2149 · Cited by 74 · see citing works
Self-citationSugaya, N., Shinjoh, M., Mitamura, K., & Takahashi, T. (2011) · Journal of Infection · doi:10.1016/j.jinf.2011.06.008 · Cited by 72 · see citing works
Applied Bayesian Modeling and Causal Inference from Incomplete Data Perspectives
Dialsingh, I. (2005) · Journal of the Royal Statistical Society Series A (Statistics in Society) · doi:10.1111/j.1467-985x.2005.00368_7.x · Cited by 59 · see citing works
Chemaly, R. F., Torres, H. A., Aguilera, E. A., Mattiuzzi, G. N., Cabanillas, M. E., Kantarjian, H. M., González‐Calle, V., Safdar, A., & RAAD, I. I. (2007) · Clinical Infectious Diseases · doi:10.1086/512374 · Cited by 54 · see citing works
Differences between asthmatics and nonasthmatics hospitalised with influenza A infection
Myles, P. R., Nguyen‐Van‐Tam, J. S., Semple, M. G., Brett, S. J., Bannister, B. A., Read, R. C., Taylor, B. L., McMenamin, J., Enstone, J. E., Nicholson, K. G., et al. (2012) · European Respiratory Journal · doi:10.1183/09031936.00015512 · Cited by 49 · see citing works
Self-citationSun, S., Zhao, G., Xiao, W., Hu, J., Guo, Y., Yu, H., Wu, X., Tan, Y., & Zhou, Y. (2011) · Virology Journal · doi:10.1186/1743-422x-8-52 · Cited by 42 · see citing works
Adjunctive therapies and immunomodulating agents for severe influenza
Hui, D. S. C., & Lee, N. L. S. (2013) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12171 · Cited by 37 · see citing works
Estimating Effect of Antiviral Drug Use during Pandemic (H1N1) 2009 Outbreak, United States
Atkins, C. Y. (2011) · Emerging infectious diseases · doi:10.3201/eid1709.110295 · Cited by 31 · see citing works
Chowell, G., Viboud, C. G., Simonsen, L., Miller, M. A., Echevarría‐Zuno, S., González-León, M., & Aburto, V. H. B. (2012) · BMC Infectious Diseases · doi:10.1186/1471-2334-12-97 · Cited by 29 · see citing works
Safety profile of oseltamivir during the 2009 influenza pandemic
Donner, B., Bader‐Weder, S., Schwarz, R., Peng, M. M., Smith, J., & Niranjan, V. (2011) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.2136 · Cited by 23 · see citing works
Nakai, A., Minakami, H., Unno, N., et al. (2011) · Journal of Infection · doi:10.1016/j.jinf.2011.01.002 · Cited by 21 · see citing works
Miller, P. E., Rambachan, A., Hubbard, R. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043491 · Cited by 11 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [5]Hassan K, McGeer A, Green KA, Antiviral therapy improves outcomes of influenza infections in patients requiring admission to intensive care. 49th Interscience Conference on Antimicrobial Agents and Chemotherapy; San Francisco, CA; Sept 12–15, 2009. V-537
- [21]Myles P, Leonardi-Bee J, Van-Tam J, Muthuri S, Venkatesan S. A systematic review of the impact of neuraminidase inhibitor antiviral use on outcomes of public health importance during the 2009/10 (swine) influenza A/H1N1v pandemic. http://www.crd.york.ac.uk/NIHR_PROSPERO/display_record.asp?ID=CRD42011001273#.UvDWqFFNKW8 (accessed Feb 4, 2014). PMC3549600 23204175
Cited by
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Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935 · see citing works
Influenza-associated Aspergillosis in Critically Ill Patients
van de Veerdonk, F. L., Kolwijck, E., Lestrade, P. P. A., Hodiamont, C. J., Rijnders, B. J. A., van Paassen, J., Haas, P.-J., Oliveira dos Santos, C., Kampinga, G. A., Bergmans, D. C. J. J., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201612-2540le · Cited by 230 · see citing works
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082 · see citing works
Intensive care management of influenza-associated pulmonary aspergillosis
Koehler, P., Bassetti, M., Kochanek, M., Shimabukuro-Vornhagen, A., & Cornely, O. A. (2019) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2019.04.031 · Cited by 82 · see citing works
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- Authors
- Muthuri, S. G., Venkatesan, S., Myles, P. R., Leonardi-Bee, J., Al Khuwaitir, T. S. A., Al Mamun, A., Anovadiya, A. P., Azziz-Baumgartner, E., Báez, C., Bassetti, M., Beovic, B., Bertisch, B., Bonmarin, I., Booy, R., Borja-Aburto, V. H., Burgmann, H., Cao, B., Carratala, J., Denholm, J. T., Dominguez, S. R., Duarte, P. A. D., Dubnov-Raz, G., Echavarria, M., Fanella, S., Gao, Z., Gérardin, P., Giannella, M., Gubbels, S., Herberg, J., Iglesias, A. L. H., Hoger, P. H., Hu, X., Islam, Q. T., Jiménez, M. F., Kandeel, A., Keijzers, G., Khalili, H., Knight, M., Kudo, K., Kusznierz, G., Kuzman, I., Kwan, A. M. C., Amine, I. L., Langenegger, E., Lankarani, K. B., Leo, Y.-S., Linko, R., Liu, P., Madanat, F., Mayo-Montero, E., McGeer, A., Memish, Z., Metan, G., Mickiene, A., Mikić, D., Mohn, K. G. I., Moradi, A., Nymadawa, P., Oliva, M. E., Ozkan, M., Parekh, D., Paul, M., Polack, F. P., Rath, B. A., Rodríguez, A. H., Sarrouf, E. B., Seale, A. C., Sertogullarindan, B., Siqueira, M. M., Skręt-Magierło, J., Stephan, F., Talarek, E., Tang, J. W., To, K. K. W., Torres, A., Törün, S. H., Tran, D., Uyeki, T. M., Van Zwol, A., Vaudry, W., Vidmar, T., Yokota, R. T. C., Zarogoulidis, P., & Nguyen-Van-Tam, J. S.
- Affiliations
- University of Nottingham (GB)
- Government Medical College Bhavnagar (IN)
- Ministerio de Salud (AR)
- Ospedale Santa Maria della Misericordia di Udine (IT)
- Kantonsspital St. Gallen (CH)
- Institut de Veille Sanitaire (FR)
- The University of Sydney (AU)
- Medical University of Vienna (AT)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Peter Doherty Institute (AU)
- Children's Hospital Colorado (US)
- University of Manitoba (CA)
- Peking University People's Hospital (CN)
- Inserm (FR)
- Hospital General Universitario Gregorio Marañón (ES)
- Statens Serum Institut (DK)
- Imperial College London (GB)
- Peking Union Medical College Hospital (CN)
- Dhaka Medical College and Hospital (BD)
- Universidade Federal de Ciências da Saúde de Porto Alegre (BR)
- Ministry of Health and Population (EG)
- Gold Coast Hospital (AU)
- Tehran University of Medical Sciences (IR)
- University of Oxford (GB)
- National Center for Global Health and Medicine (JP)
- University of Zagreb (HR)
- Pamela Youde Nethersole Eastern Hospital (CN)
- Mohammed V University (MA)
- Stellenbosch University (ZA)
- Shiraz University (IR)
- Tan Tock Seng Hospital (SG)
- Helsinki University Hospital (FI)
- First Hospital of China Medical University (CN)
- King Hussein Cancer Center (JO)
- Ministerio de Defensa (ES)
- University of Toronto (CA)
- Alfaisal University (SA)
- Military Medical Academy (RS)
- Haukeland University Hospital (NO)
- Johns Hopkins University (US)
- National Center for Communicable Diseases (MN)
- University of Birmingham (GB)
- Rambam Health Care Campus (IL)
- Vanderbilt University (US)
- Charité – Universitätsmedizin Berlin (DE)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Bristol Royal Hospital for Children (GB)
- Instituto Oswaldo Cruz (BR)
- University of Rzeszów (PL)
- Medical University of Warsaw (PL)
- University of Alberta (CA)
- Queen Mary Hospital (CN)
- Istanbul University (TR)
- Centers for Disease Control and Prevention (US)
- Splošna Bolnišnica Slovenj Gradec (SI)
- Ministério da Saúde (BR)
- Democritus University of Thrace (GR)
- ORCID
- Muthuri, Stella G
- Venkatesan, Sudhir
- Myles, Puja R
- Anovadiya, Ashish P
- Bassetti, Matteo
- Bertisch, Barbara
- Bonmarin, Isabelle
- Booy, Robert
- Burgmann, Heinz
- Cao, Bin
- Denholm, Justin T
- Dominguez, Samuel R
- Fanella, Sergio
- Gao, Zhancheng
- Gérardin, Patrick
- Giannella, Maddalena
- Gubbels, Sophie
- Herberg, Jethro
- Jiménez, Mirela F
- Kandeel, Amr
- Keijzers, Gerben
- Khalili, Hossein
- Knight, Marian
- Kusznierz, Gabriela
- Amine, Idriss Lahlou
- Langenegger, Eduard
- Lankarani, Kamran B
- Leo, Yee-Sin
- Liu, Pei
- McGeer, Allison
- Memish, Ziad
- Mohn, Kristin G I
- Moradi, Ahmadreza
- Nymadawa, Pagbajabyn
- Parekh, Dhruv
- Paul, Mical
- Polack, Fernando P
- Rath, Barbara A
- Rodríguez, Alejandro H
- Sarrouf, Elena B
- Seale, Anna C
- Siqueira, Marilda M
- Skręt-Magierło, Joanna
- Talarek, Ewa
- Tang, Julian W
- To, Kelvin K W
- Törün, Selda H
- Tran, Dat
- Uyeki, Timothy M
- Vaudry, Wendy
- Zarogoulidis, Paul
- Venue
- The Lancet Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 2
- Issue
- 5
- Pages
- 395-404
- ISSN
- 2213-2600 (ISSN-L)
- PMC
- PMC6637757
- OpenAlex
- W2102263282
- Cited by
- 644
- References
- 33
- Citations by year
- 2026: 14 · 2025: 38 · 2024: 34 · 2023: 37 · 2022: 46 · 2021: 51 · 2020: 61 · 2019: 64 · 2018: 52 · 2017: 59 · 2016: 78 · 2015: 55 · 2014: 54 · 2013: 1
- FWCI
- 10.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet Respiratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- The HKU Scholars Hub (University of Hong Kong) (acceptedVersion, cc-by-nc-nd)
- Van Yüzüncü Yıl University Academic Data Management System (submittedVersion)
- HAL (submittedVersion, other-oa)
- Institutional Research Information System (University of Udine) (submittedVersion)
- Arca - Repositório Institucional da Fiocruz (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Nottingham ePrints (University of Nottingham) (submittedVersion, cc-by)
- Lithuanian University of Health Sciences (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Griffith Research Online (submittedVersion, cc-by-nc-nd)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institute for Health and Care Research (11/46/12, NIHR-RP-011-032, CL-2007-21-012)
- European Centre for Disease Prevention and Control
- Radboud Universiteit
- Radboud Universitair Medisch Centrum
- National Institutes of Health (CC999999)
- Medical Research Council (MR/J011266/1)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- neuraminidase inhibitors, influenza A(H1N1)pdm09, pandemic influenza, mortality, hospitalized patients, antiviral treatment timing, early treatment, treatment effectiveness, children, 2009-2010 influenza pandemic, individual patient data meta-analysis, influenza C
- MeSH terms
- Adolescent, Adult, Antiviral Agents, Child, Enzyme Inhibitors, Female, Hospitalization, Humans, Influenza, Human, Male, Middle Aged, Neuraminidase, Proportional Hazards Models, Treatment Outcome, Influenza A Virus, H1N1 Subtype, Oseltamivir, Zanamivir, Young Adult, Pandemics
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