The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Sleep apnoea and the brain: a complex relationship
Abstract
Intermittent hypoxia, reoxygenation, and hypercapnia or hypocapnia occur in both adults and children during untreated apnoea and hypopnoea, along with changes in cerebral blood flow and sleep fragmentation. These effects can result in cognitive deficits with functional effects on work and school efficiency. The assessment of how obstructive sleep apnoea affects cognition depends on the specificity and sensitivity of the tests, which are rarely developed specifically for obstructive sleep apnoea. In this Review, we discuss both the neural adaptive and maladaptive processes in response to hypoxaemia. The net result on cognitive and emotional performance depends on the stage of this dynamic process, effects on other body systems, cognitive reserve, and idiosyncratic susceptibility. We also explore the contribution of fragmented sleep, and the disruption of sleep structure, with focus on the effect at different times in the development of disease. This Review will address the gap in the underlying pathophysiology of new clinical and translational findings, and argue their contribution to the inherent complexity of the association between obstructive sleep apnoea and the brain.
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Cites
The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults
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Increased Prevalence of Sleep-Disordered Breathing in Adults
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Cited by
A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain
Wang, J., Gu, B. J., Masters, C. L., & Wang, Y.-J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.111 · Cited by 808
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
Lv, R., Liu, X., Zhang, Y., Dong, N., Wang, X., He, Y., Yue, H., & Yin, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01496-3 · Cited by 477
Bubu, O. M., Andrade, A. G., Umasabor-Bubu, O. Q., Hogan, M. M., Turner, A. D., de Leon, M. J., Ogedegbe, G., Ayappa, I., Jean-Louis G, G., Jackson, M. L., et al. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2019.101250 · Cited by 389
The Association Between Obstructive Sleep Apnea and Alzheimer’s Disease: A Meta-Analysis Perspective
Emamian, F., Khazaie, H., Tahmasian, M., Leschziner, G. D., Morrell, M. J., Hsiung, G.-Y. R., Rosenzweig, I., & Sepehry, A. A. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00078 · Cited by 258
Self-citationDauvilliers, Y., Verbraecken, J., Partinen, M., Hedner, J., Saaresranta, T., Georgiev, O., Tiholov, R., Lecomte, I., Tamisier, R., Lévy, P., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201907-1284oc · Cited by 268
Metadata
- Authors
- Rosenzweig, I., Glasser, M., Polsek, D., Leschziner, G. D., Williams, S. C. R., & Morrell, M. J.
- Venue
- The Lancet Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 3
- Issue
- 5
- Pages
- 404-414
- ISSN
- 2213-2600 (ISSN-L)
- OpenAlex
- W2109752705
- Cited by
- 277
- References
- 109
- FWCI
- 16.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rosenzweig, I., Glasser, M., Polsek, D., Leschziner, G. D., Williams, S. C. R., & Morrell, M. J. (2015). Sleep apnoea and the brain: a complex relationship. The Lancet Respiratory Medicine. https://doi.org/10.1016/s2213-2600(15)00090-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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