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Ipilimumab-induced autoimmune adrenalitis
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“The occurrence of AI in ICI users has been reported in about 1% of cases and more frequently in individuals receiving combination regimens like anti-CTLA4 plus anti-PD1/PD-L1 agents (4%-8%) (25, 28, 29).”
From The Changing Face of Drug-induced Adrenal Insufficiency in the Food and Drug Administration Adverse Event Reporting System (2022) · cites this paper as [28]
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(2013) · Reactions Weekly · doi:10.1007/s40278-013-7766-3
Immunotherapy and Endocrine Oncology
Contreras, M., Sánchez, J. C., & Iglesias, P. (2022) · Springer eBooks · doi:10.1007/978-3-030-80962-1_242-1
Лактионов, К. К., Саранцева, К. А., Yudin, D. I., Beloyartseva, M., & Сергеевич, Ю. Г. (2021) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2021-4s-108-113
Endocrine Consequences Following Immune Checkpoint Inhibitors Therapy
Lavrentaki, A., & Ntali, G. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_172-1
Isaacs, J. M., Shariff, A. I., & Crawford, J. (2023) · Springer eBooks · doi:10.1007/978-3-030-93702-7_12-1
Isaacs, J. M., Shariff, A. I., Crawford, J., Khouri, M. G., Kheterpal, M., Sammons, S. L., Ferreira, M., Wall, A., Onken, J. E., King, L., et al. (2024) · Springer eBooks · doi:10.1007/978-3-030-93702-7_12-2
Immunotherapy for Endocrine Oncology
Contreras, M., Sánchez, J. C., & Iglesias, P. (2024) · Springer eBooks · doi:10.1007/978-3-030-80962-1_242-2
Colombo, C., Leo, S. D., Campisi, I., Palesandro, E., Turco, F., Buttigliero, C., Fugazzola, L., & Tucci, M. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104627 · Cited by 1
Immunotherapy for Endocrine Oncology
Contreras, M., Sánchez, J. C., & Iglesias, P. (2025) · Springer eBooks · doi:10.1007/978-3-032-00769-8_242
Endocrine Consequences Following Immune Checkpoint Inhibitors Therapy
Lavrentaki, A., & Ntali, G. (2025) · Springer eBooks · doi:10.1007/978-3-032-00765-0_172
Endocrine late-effects in survivors of childhood and adolescence cancer: clinical management
Biasin, E., Felicetti, F., Cattoni, A., Aloj, G., Giorgiani, G., Gorio, C., Haupt, R., Mastronuzzi, A., Muraca, M., Pillon, M., et al. (2026) · Journal of Endocrinological Investigation · doi:10.1007/s40618-026-02824-4 · Cited by 1
Kase, C., Takahashi, K., Ogino, J., Watanabe, S., & Toriihara, A. (2026) · Cureus · doi:10.7759/cureus.108272
“Radiological findings of primary adrenal insufficiency due to irAEs include bilateral adrenal enlargement and increased FDG uptake suggestive of inflammation [7-10].”
Metadata
- Authors
- Min, L., & Ibrahim, N.
- Affiliations
- Brigham and Women's Hospital (US)
- Dana-Farber Cancer Institute (US)
- Venue
- The Lancet Diabetes & Endocrinology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 1
- Issue
- 3
- Pages
- e15
- ISSN
- 2213-8587 (ISSN-L)
- PMC
- PMC4106239
- OpenAlex
- W2032060513
- Cited by
- 112
- References
- 0
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 15 · 2020: 19 · 2019: 16 · 2018: 10 · 2017: 8 · 2016: 7 · 2015: 4 · 2014: 1 · 2013: 1
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Diabetes & Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007529)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K08HD070957)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- ipilimumab, autoimmune adrenalitis, Addison's disease, secondary adrenal insufficiency, CTLA-4 blockade, melanoma, hypophysitis, aldosterone, hydrocortisone replacement
- MeSH terms
- Ipilimumab, Adrenal Gland Diseases, Adrenal Insufficiency, Antibodies, Monoclonal, Autoimmune Diseases, Female, Humans, Inflammation, Melanoma, Middle Aged, Tomography, X-Ray Computed
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