Cited by 154Adipose Tissue and MetabolismThyroid Disorders and TreatmentsAdipokines, Inflammation, and Metabolic Diseases

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The role of thyroid hormone and brown adipose tissue in energy homoeostasis

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Bianco, Antonio C, McAninch, Elizabeth A·2013·The Lancet Diabetes & Endocrinology

DOI 10.1016/s2213-8587(13)70069-xPMC PMC4976626

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Abstract

The presence of brown adipose tissue (BAT) in adults has become increasingly well defined as a result of functional imaging studies of thermogenically active BAT. Findings from these studies have created a surge of scientific interest in BAT, because it represents a potential therapeutic target for obesity--a condition with profound health consequences and few successful therapies. BAT contributes to overall energy expenditure in small mammals and neonates through adaptive thermogenesis. Thyroid-hormone signalling, particularly through induction of type II deiodinase, has a central role in brown adipogenesis in vitro and BAT development in mouse embryos. Additionally, because of high intracellular expression of type II deiodinase, adult BAT has enhanced thyroid-hormone signalling with several thyroid-hormone-dependent thermogenic pathways, including expression of the genes Ppargc1a and Ucp1. BAT thermogenesis explains the essential part played by thyroid hormone in energy homoeostasis and adaptation to cold. Stimulation of BAT in adults, specifically through thyroid-hormone-mediated pathways, is a promising therapeutic target for obesity.

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Authors: Bianco, A. C., & McAninch, E. A.
Affiliations: University of Miami (US)
ORCID: Bianco, Antonio C
McAninch, Elizabeth A
Venue: The Lancet Diabetes & Endocrinology
Publisher: Elsevier BV
Published: 2013-11
Volume: 1
Issue: 3
Pages: 250-258
ISSN: 2213-8587 (ISSN-L)
DOI: 10.1016/s2213-8587(13)70069-x
PMC: PMC4976626
OpenAlex: W2097615700
Cited by: 154
References: 96
Citations by year: 2026: 8 · 2025: 17 · 2024: 11 · 2023: 13 · 2022: 11 · 2021: 16 · 2020: 12 · 2019: 20 · 2018: 12 · 2017: 7 · 2016: 8 · 2015: 9 · 2014: 10
FWCI: 0.99
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Lancet Diabetes & Endocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK065055, R01DK077148)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: brown adipose tissue, thyroid hormones, energy homeostasis, adaptive thermogenesis, type 2 deiodinase, brown adipogenesis, PGC-1α, UCP1, obesity, cold adaptation, energy expenditure
MeSH terms: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Uncoupling Protein 1, Adult, Animals, Adipose Tissue, Brown, Energy Metabolism, Homeostasis, Humans, Iodide Peroxidase, Ion Channels, Models, Biological, Obesity, Thyroid Hormones, Transcription Factors, Signal Transduction, Thermogenesis, Mitochondrial Proteins, Mice

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The role of thyroid hormone and brown adipose tissue in energy homoeostasis

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