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The role of thyroid hormone and brown adipose tissue in energy homoeostasis
Open accessAbstract
The presence of brown adipose tissue (BAT) in adults has become increasingly well defined as a result of functional imaging studies of thermogenically active BAT. Findings from these studies have created a surge of scientific interest in BAT, because it represents a potential therapeutic target for obesity--a condition with profound health consequences and few successful therapies. BAT contributes to overall energy expenditure in small mammals and neonates through adaptive thermogenesis. Thyroid-hormone signalling, particularly through induction of type II deiodinase, has a central role in brown adipogenesis in vitro and BAT development in mouse embryos. Additionally, because of high intracellular expression of type II deiodinase, adult BAT has enhanced thyroid-hormone signalling with several thyroid-hormone-dependent thermogenic pathways, including expression of the genes Ppargc1a and Ucp1. BAT thermogenesis explains the essential part played by thyroid hormone in energy homoeostasis and adaptation to cold. Stimulation of BAT in adults, specifically through thyroid-hormone-mediated pathways, is a promising therapeutic target for obesity.
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“In brown adipocytes, T4 can be converted to its active form T3 via type 2 iodothyronine deiodinase (DIO2) thus compensating for the low levels of thyroid gland‐secreted T3 88.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [88]
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Metadata
- Authors
- Bianco, A. C., & McAninch, E. A.
- Affiliations
- University of Miami (US)
- Venue
- The Lancet Diabetes & Endocrinology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 1
- Issue
- 3
- Pages
- 250-258
- ISSN
- 2213-8587 (ISSN-L)
- PMC
- PMC4976626
- OpenAlex
- W2097615700
- Cited by
- 154
- References
- 96
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 11 · 2023: 13 · 2022: 11 · 2021: 16 · 2020: 12 · 2019: 20 · 2018: 12 · 2017: 7 · 2016: 8 · 2015: 9 · 2014: 10
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Diabetes & Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK065055, R01DK077148)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- brown adipose tissue, thyroid hormones, energy homeostasis, adaptive thermogenesis, type 2 deiodinase, brown adipogenesis, PGC-1α, UCP1, obesity, cold adaptation, energy expenditure
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Uncoupling Protein 1, Adult, Animals, Adipose Tissue, Brown, Energy Metabolism, Homeostasis, Humans, Iodide Peroxidase, Ion Channels, Models, Biological, Obesity, Thyroid Hormones, Transcription Factors, Signal Transduction, Thermogenesis, Mitochondrial Proteins, Mice
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