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Dysglycaemia definitions and progression to clinical type 1 diabetes in children with multiple islet autoantibodies
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Stage 1 is defined by the presence of at least two islet autoantibodies and normoglycaemia, and accounts for 80-90% of individuals with presymptomatic disease.
“Stage 1 is defined by the presence of at least two islet autoantibodies and normoglycaemia, and accounts for 80-90% of individuals with presymptomatic disease.8,12”
From The future of type 1 diabetes therapy (2025) · cites this paper as [12]
Stage 2 is defined by positive islet autoantibodies accompanied by dysglycaemia.
“Stage 2 is defined by positive islet autoantibodies accompanied by dysglycaemia.8,12”
From The future of type 1 diabetes therapy (2025) · cites this paper as [12]
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References 10 · Cited by 16
Research works printed but not linked: 7
- Insel, 2015, Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association, Diabetes Care, 38, 1964, 10.2337/dc15-1419 · DOI · Paper page
- Phillip, 2024, Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes, Diabetes Care, 47, 1276
- ElSayed, 2024, 2. Diagnosis and classification of diabetes: standards of care in diabetes-2024, Diabetes Care, 47, S20
- Ziegler, 2020, Yield of a public health screening of children for islet autoantibodies in Bavaria, Germany, JAMA, 323, 339, 10.1001/jama.2019.21565 · DOI · Paper page
- Weiss, 2022, Progression likelihood score identifies substages of presymptomatic type 1 diabetes in childhood public health screening, Diabetologia, 65, 2121, 10.1007/s00125-022-05780-9 · DOI
- Ismail, 2022, The transition from a compensatory increase to a decrease in c-peptide during the progression to type 1 diabetes and its relation to risk, Diabetes Care, 45, 2264, 10.2337/dc22-0167 · DOI
- Linsley, 2021, Uncovering pathways to personalized therapies in type 1 diabetes, Diabetes, 70, 831, 10.2337/db20-1185 · DOI
Metadata
- Authors
- Hummel, S., Koeger, M., Bonifacio, E., & Ziegler, A.-G.
- Affiliations
- TUM Klinikum (DE)
- Helmholtz Munich (DE)
- Corresponding author
- Ziegler, Anette-Gabriele
- Venue
- The Lancet Diabetes & Endocrinology
- Publisher
- Elsevier BV
- Published
- 2025-01
- Volume
- 13
- Issue
- 1
- Pages
- 10-12
- ISSN
- 2213-8587 (ISSN-L)
- OpenAlex
- W4404986067
- Cited by
- 16
- References
- 10
- Citations by year
- 2026: 10 · 2025: 6
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Diabetes & Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- dysglycemia, type 1 diabetes, islet autoantibodies, children, disease progression, diagnostic criteria, autoimmunity
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