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Cited by 212Multiple Myeloma Research and TreatmentsNeutropenia and Cancer InfectionsInfection Control in Healthcare

Consensus guidelines and recommendations for infection prevention in multiple myeloma: a report from the International Myeloma Working Group

Raje, Noopur S, Anaissie, Elias, Kumar, Shaji K, Lonial, Sagar, Martin, Thomas, Gertz, Morie A, Krishnan, Amrita, Hari, Parameswaran +28 more·2022·The Lancet Haematology
DOI 10.1016/s2352-3026(21)00283-0
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Abstract

Infection remains the leading cause of morbidity and mortality in patients with multiple myeloma because of the cumulative effect of disease, treatment, and host-related factors. Given that infectious risk is cumulative through the course of the disease, preventing infections is paramount. Optimal preventive strategies include vaccination against common pathogens, antimicrobial prophylaxis, infection control measures, and immunoglobulin replacement in a small subset of patients; however, there are no universally accepted guidelines for infection prevention. This Review provides a consensus statement from a panel of 36 experts with global representation, which was convened by The International Myeloma Society to review existing literature and current guidelines, address issues associated with the risk of infection and prevention of infectious complications in multiple myeloma in the context of emerging therapies, and offer recommendations for preventing these complications.

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  • Early infection prevention, including immunoglobulin replacement per IMWG guidelines, reduces high-grade infections in patients receiving bispecific antibodies.

    “Results further emphasize the importance of early infection prevention in patients receiving bispecific antibodies, including use of immunoglobulin replacement per IMWG guidelines to reduce high-grade infections.36–40”

    From Teclistamab plus Daratumumab in Relapsed or Refractory Multiple Myeloma (2026) · cites this paper as [37]

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Authors
Raje, N. S., Anaissie, E., Kumar, S. K., Lonial, S., Martin, T., Gertz, M. A., Krishnan, A., Hari, P., Ludwig, H., O'Donnell, E., Yee, A., Kaufman, J. L., Cohen, A. D., Garderet, L., Wechalekar, A. F., Terpos, E., Khatry, N., Niesvizky, R., Yi, Q., Joshua, D. E., Saikia, T., Leung, N., Engelhardt, M., Mothy, M., Branagan, A., Chari, A., Reiman, A. J., Lipe, B., Richter, J., Rajkumar, S. V., Miguel, J. S., Anderson, K. C., Stadtmauer, E. A., Prabhala, R. H., McCarthy, P. L., & Munshi, N. C.
Affiliations
  • Harvard University (US)
  • Clinical Trial and Consulting (US)
  • Mayo Clinic (US)
  • Emory University (US)
  • University of California, San Francisco (US)
  • City Of Hope National Medical Center (US)
  • Medical College of Wisconsin (US)
  • Wilhelminen Hospital (AT)
  • Abramson Cancer Center (US)
  • Assistance Publique – Hôpitaux de Paris (FR)
  • National and Kapodistrian University of Athens (GR)
  • Homi Bhabha National Institute (IN)
  • Houston Methodist (US)
  • Royal Prince Alfred Hospital (AU)
  • Prince Aly Khan Hospital (IN)
  • University of Freiburg (DE)
  • Tisch Cancer Institute (US)
  • University of Rochester Medicine (US)
  • Roswell Park Comprehensive Cancer Center (US)
ORCID
Venue
The Lancet Haematology
Publisher
Elsevier BV
Published
2022-02
Volume
9
Issue
2
Pages
e143-e161
ISSN
2352-3026 (ISSN-L)
DOI
10.1016/s2352-3026(21)00283-0
OpenAlex
W4210632919
Cited by
212
References
4
Citations by year
2026: 50 · 2025: 58 · 2024: 52 · 2023: 35 · 2022: 13 · 2013: 1
FWCI
28.77
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Lancet Haematology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
  • Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
  • Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
Keywords
multiple myeloma, infection control, infectious complications, vaccination, antibiotic prophylaxis, immunoglobulin replacement therapy, new drugs, consensus recommendations
MeSH terms
Humans, Infections, Multiple Myeloma, Consensus

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