The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Is there a causal relationship between obesity and puberty?
Abstract
The onset of puberty in adolescents and whether it is related to obesity is an ongoing topic for debate. Epidemiological cross-sectional and longitudinal studies show a shift towards earlier onset of puberty in girls who are obese; however, the situation is less clear in boys. Boys who are overweight seem to mature earlier, and boys who are obese mature later, than boys at a healthy weight. The underlying mechanisms are not yet fully understood, and whether earlier onset of puberty in obese girls is based on the activation of the hypothalamic-pituitary-gonadal axis is unclear. The most promising link between obesity and puberty is the adipokine leptin and its interaction with the kisspeptin system, which is an important regulator of puberty. However, peripheral action of adipose tissue (eg, via other adipokines, aromatase activity) could also be involved in changes to the onset of puberty. In addition, nutritional factors, epigenetics, or endocrine disrupting chemicals are potential mediators linking the onset of puberty to obesity. This Review summarises our knowledge concerning the relationship between obesity and onset and tempo of puberty, and the consequences of early puberty on obesity.
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Cites
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Cited by
Obesity in children and adolescents: epidemiology, causes, assessment, and management
Jebeile, H., Kelly, A. S., O'Malley, G., & Baur, L. A. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(22)00047-x · Cited by 1,099
Analysis of early-life growth and age at pubertal onset in US children
Aris, I. M., Perng, W., Dabelea, D., Ganiban, J. M., Liu, C., Marceau, K., Robertson, O. C., Hockett, C. W., Mihalopoulos, N. L., Kong, X., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.46873 · Cited by 47
Overview of Pediatric Obesity as a Disease
Waldrop, S. W., Ibrahim, A. A., Maya, J., Monthe-Dreze, C., & Stanford, F. C. (2024) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2024.06.003 · Cited by 6
Metadata
- Authors
- Reinehr, T., & Roth, C. L.
- Venue
- The Lancet Child & Adolescent Health
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 3
- Issue
- 1
- Pages
- 44-54
- ISSN
- 2352-4642 (ISSN-L)
- OpenAlex
- W2900598537
- Cited by
- 265
- References
- 130
- FWCI
- 15.72
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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