The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Inflammation and malnutrition in inflammatory bowel disease
Abstract
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, has become increasingly prevalent worldwide in the past decade. The nutritional status of patients with IBD is often impaired, with malnutrition presenting as imbalanced energy or nutrient intake, including protein-energy malnutrition, disease-related malnutrition, sarcopenia, and micronutrient deficiency. Additionally, malnutrition can manifest as overweight, obesity, and sarcopenic obesity. Malnutrition can lead to disturbances in gut microbiome composition that might alter homoeostasis and cause a dysbiotic state, potentially triggering inflammatory responses. Despite the clear link between IBD and malnutrition, little is known about the pathophysiological mechanisms beyond protein-energy malnutrition and micronutrient deficiencies that could promote inflammation through malnutrition, and vice versa. This Review focuses on potential mechanisms that trigger a vicious cycle between malnutrition and inflammation, and their clinical and therapeutic implications.
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Cites
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ESPEN guidelines on definitions and terminology of clinical nutrition
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ESPEN guideline: Clinical nutrition in surgery
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Sarcopenic obesity: definition, cause and consequences
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Cited by
Barberio, B., Bertin, L., Facchin, S., Bonazzi, E., Cusano, S., Romanelli, G., Pesenti, F. F., Cazzaniga, E., Palestini, P., Zingone, F., et al. (2025) · Nutrients · doi:10.3390/nu17111879 · Cited by 28
Parenteral Nutrition, Inflammatory Bowel Disease, and Gut Barrier: An Intricate Plot
Covello, C., Becherucci, G., Di Vincenzo, F., Del Gaudio, A., Pizzoferrato, M., Cammarota, G., Gasbarrini, A., Scaldaferri, F., & Mentella, M. C. (2024) · Nutrients · doi:10.3390/nu16142288 · Cited by 21
Metadata
- Authors
- Massironi, S., Viganò, C., Palermo, A., Pirola, L., Mulinacci, G., Allocca, M., Peyrin-Biroulet, L., & Danese, S.
- Venue
- The Lancet Gastroenterology & Hepatology
- Publisher
- Elsevier BV
- Published
- 2023-06
- Volume
- 8
- Issue
- 6
- Pages
- 579-590
- ISSN
- 2468-1156 (ISSN-L)
- 2468-1253
- OpenAlex
- W4324332993
- Cited by
- 298
- References
- 83
- FWCI
- 43.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Massironi, S., Viganò, C., Palermo, A., Pirola, L., Mulinacci, G., Allocca, M., Peyrin-Biroulet, L., & Danese, S. (2023). Inflammation and malnutrition in inflammatory bowel disease. The Lancet Gastroenterology & Hepatology. https://doi.org/10.1016/s2468-1253(23)00011-0
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