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Cited by 1,009Inflammatory Bowel DiseaseNutritional Studies and DietGut microbiota and health

Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature

Hou, Jason K, Abraham, Bincy, El-Serag, Hashem·2011·American Journal of Gastroenterology
DOI 10.1038/ajg.2011.44
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Abstract

OBJECTIVES: The incidence of inflammatory bowel disease (IBD) is increasing. Dietary factors such as the spread of the "Western" diet, high in fat and protein but low in fruits and vegetables, may be associated with the increase. Although many studies have evaluated the association between diet and IBD risk, there has been no systematic review. METHODS: We performed a systematic review using guideline-recommended methodology to evaluate the association between pre-illness intake of nutrients (fats, carbohydrates, protein) and food groups (fruits, vegetables, meats) and the risk of subsequent IBD diagnosis. Eligible studies were identified via structured keyword searches in PubMed and Google Scholar and manual searches. RESULTS: Nineteen studies were included, encompassing 2,609 IBD patients (1,269 Crohn's disease (CD) and 1,340 ulcerative colitis (UC) patients) and over 4,000 controls. Studies reported a positive association between high intake of saturated fats, monounsaturated fatty acids, total polyunsaturated fatty acids (PUFAs), total omega-3 fatty acids, omega-6 fatty acids, mono- and disaccharides, and meat and increased subsequent CD risk. Studies reported a negative association between dietary fiber and fruits and subsequent CD risk. High intakes of total fats, total PUFAs, omega-6 fatty acids, and meat were associated with an increased risk of UC. High vegetable intake was associated with a decreased risk of UC. CONCLUSIONS: High dietary intakes of total fats, PUFAs, omega-6 fatty acids, and meat were associated with an increased risk of CD and UC. High fiber and fruit intakes were associated with decreased CD risk, and high vegetable intake was associated with decreased UC risk.

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  • A systematic review found that high intake of total fats, polyunsaturated fatty acids, omega-6 fatty acids, and meat was associated with increased risk of CD and UC; high fiber and fruit intake was associated with decreased risk of CD; and high vegetable intake was associated with decreased risk of UC.

    “A systematic review concluded that diets with high levels of total fats, polyunsaturated fatty acids, omega-6 fatty acids, and meat were associated with an increased risk of CD and UC; high fiber and high fruit intake were associated with a decreased risk of CD, whereas high vegetable intake was associated with a decreased for UC65.”

    From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [65]

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  1. Miller, 1976, Sugar consumption in patients with Crohns disease (article in German)., Verh Dtsch Ges Inn Med, 82, 922

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Authors
Hou, J. K., Abraham, B., & El-Serag, H.
Affiliations
  • Michael E. DeBakey VA Medical Center (US)
  • Baylor College of Medicine (US)
Corresponding author
Hou, Jason K
ORCID
Venue
American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-04
Volume
106
Issue
4
Pages
563-573
ISSN
0002-9270 (ISSN-L)
DOI
10.1038/ajg.2011.44
OpenAlex
W2030631780
Semantic Scholar
846fa3e7e7f98a379c5e4b67d65a7f58ab57640c
Cited by
1,009
References
33
Citations by year
2026: 35 · 2025: 72 · 2024: 84 · 2023: 105 · 2022: 96 · 2021: 83 · 2020: 65 · 2019: 88 · 2018: 43 · 2017: 65 · 2016: 67 · 2015: 52 · 2014: 53 · 2013: 54 · 2012: 39
FWCI
5.23
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (unspecified)
Locations
  • The American Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK-56338, P30DK056338)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
inflammatory bowel disease, Crohn's disease, ulcerative colitis, dietary intake, Western diet, saturated fat, polyunsaturated fatty acids, omega-6 fatty acids, omega-3 fatty acids, dietary fiber, fruit consumption, vegetable consumption, meat consumption, dietary risk factors
MeSH terms
Colitis, Ulcerative, Crohn Disease, Diet, Dietary Carbohydrates, Dietary Fats, Dietary Fiber, Dietary Proteins, Fatty Acids, Unsaturated, Fruit, Humans, Meat, Vegetables, Inflammatory Bowel Diseases, Risk Assessment, Fatty Acids, Omega-6

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