Altered cingulum bundle microstructure in autism spectrum disorder
Abstract
Objective Here, we examined the cingulum bundle, a long-range white matter tract mediating dorsal limbic connectivity, using diffusion tensor imaging (DTI) tractography, in children and adolescents with autism spectrum disorder (ASD) versus controls. We hypothesised that cingulum bundle microstructure would be altered in ASD, based on evidence implicating abnormal white matter connectivity in this disorder. Methods DTI data were acquired for 19 ASD participants (IQ ⩾ 70; 7-18 years; mean = 12.4 ± 3.1) and 16 age-matched controls (7-18 years; mean = 12.3 ± 3.6) on a 3 T magnetic resonance imaging system. Deterministic tractography was used to isolate the cingulum bundle. Left and right cingulum bundles were examined for differences in several DTI metrics in ASD children/adolescents versus controls, including: fractional anisotropy (FA), mean, axial, and radial diffusivity. Results Significant age × group interaction effects were found for all DTI metrics (mean diffusivity: F 1,28 = 9.5, p = 0.005, radial diffusivity: F 1,28 = 7.8, p = 0.009, axial diffusivity: F 1,28 = 5.2, p = 0.03, FA: F 1,28 = 4.4, p = 0.04). Interaction effects were driven by increases in cingulum bundle diffusivity (mean, radial, and axial diffusivity), and decreased FA, in younger ASD participants within our sample versus controls. Conclusion Our results point to immature microstructural organisation of the cingulum bundle in ASD, particularly during the early years of life, with implications for limbic…
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In ASD, diffusivity increases (mean and radial) are most evident in young (<11 years) participants.
“with diffusivity increases (e.g., mean and radial) most evident in young (<11 years) ASD participants (Ameis et al., 2013).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Ameis et al., 2013
In ASD studies focusing on just the cingulum, reduced FA is found.
“In those ASD studies focussing on just the cingulum, reduced FA is again found (Ameis et al., 2013; Ikuta et al., 2014)”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Ameis et al., 2013
Cites
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,653 · see citing works
Transcriptomic Analysis of Autistic Brain Reveals Convergent Molecular Pathology
Voineagu, I., Wang, X., Johnston, P., Lowe, J. K., Tian, Y., Horvath, S., Mill, J., Cantor, R. M., Blencowe, B. J., & Geschwind, D. H. (2011) · Nature · doi:10.1038/nature10110 · Cited by 1,874 · cited 2× · see citing works
“A recent study indicating dramatic reductions in differential gene expression patterns within frontal and temporal cortex in post-mortem ASD was largely driven by prominent alterations in synaptic function genes, implicating impaired development of neuronal connectivity within these broad cortical regions (4).”
BackgroundStandardizing ADOS Scores for a Measure of Severity in Autism Spectrum Disorders
Gotham, K., Pickles, A., & Lord, C. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0674-3 · Cited by 1,605 · see citing works
About “axial” and “radial” diffusivities
Wheeler‐Kingshott, C. A. M., & Cercignani, M. (2009) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21965 · Cited by 885 · see citing works
Minicolumnar pathology in autism
Casanova, M. F., Buxhoeveden, D. P., Switala, A. E., & Roy, E. (2002) · Neurology · doi:10.1212/wnl.58.3.428 · Cited by 846 · see citing works
Schumann, C. M., Bloss, C. S., Barnes, C. C., Wideman, G. M., Carper, R. A., Akshoomoff, N., Pierce, K., Hagler, D., Schork, N., Lord, C., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5714-09.2010 · Cited by 554 · see citing works
Faria, A. V., Zhang, J., Oishi, K., Li, X., Jiang, H., Akhter, K., Hermoye, L., Lee, S.-K., Hoon, A., & Stashinko, E. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.04.238 · Cited by 180 · see citing works
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The cingulum bundle: Anatomy, function, and dysfunction
Bubb, E. J., Metzler-Baddeley, C., & Aggleton, J. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.008 · Cited by 740 · see citing works
“, mean and radial) most evident in young (< 11 years) ASD participants (Ameis et al., 2013).”
- Authors
- Ameis, S. H., Fan, J., Rockel, C., Soorya, L., Wang, A. T., & Anagnostou, E.
- Affiliations
- University of Toronto (CA)
- Queens College, CUNY (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Anagnostou, Evdokia
- Venue
- Acta Neuropsychiatrica
- Publisher
- Cambridge University Press (CUP)
- Published
- 2013-02-27
- Volume
- 25
- Issue
- 5
- Pages
- 275-282
- ISSN
- 0924-2708 (ISSN-L)
- 1601-5215
- OpenAlex
- W2160990082
- Cited by
- 35
- References
- 7
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 4 · 2015: 1 · 2014: 1
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Neuropsychiatrica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, cingulum, white matter microstructure, fractional anisotropy, mean diffusivity, radial diffusivity, axial diffusivity, developmental differences, children and adolescents
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