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Effects of miglitol, an α-glucosidase inhibitor, on glycaemic status and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats
Open accessAbstract
Miglitol, a 1-deoxynojirimycin derivative, is an α-glucosidase inhibitor. In the present study, the effects of acute (single-dose) and chronic (8-week) oral administration of miglitol in Goto-Kakizaki (GK) rats, an animal model of type 2 diabetes, were investigated. Dose-dependent decreases in incremental blood glucose concentrations integrated over a period of 2 h (ΔAUC 0–2 h) for values of blood glucose after sucrose-loading in miglitol-treated GK rats were observed following an acute oral administration of miglitol (1, 3 or 10 mg/kg body weight). At 10 mg/kg, the ΔAUC 0–2 h of blood glucose was decreased by 45 % compared with the control group. Following the oral administration of miglitol in a dietary mixture (10 mg, 20 mg or 40 mg miglitol/100 g control diet) for 8 weeks, the ratio of HbA 1c at 8 weeks compared with 0 weeks in GK rats treated with 40 mg miglitol/100 g control diet miglitol was significantly decreased compared with control GK rats without changes in body weight. In oral glucose tolerance testing, miglitol caused a slight decrease in the ΔAUC 0–2 h of plasma glucose concentration. In addition, miglitol treatment slightly inhibited the reduction in β-cell mass, and lessened the irregular contours and fibrosis of the islets in GK rats. These results indicate that miglitol ameliorates the hyperglycaemic state of GK rats and the impaired function of the pancreatic islets, as well as preventing the degeneration of islets in GK rats.
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“Similar to pioglitazone, α-glucosidase inhibitors attenuate reductions in β-cell mass, which may delay the onset of diabetes.374, 375, 376”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [374]
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Metadata
- Authors
- Goda, T., Suruga, K., Komori, A., Kuranuki, S., Mochizuki, K., Makita, Y., & Kumazawa, T.
- Affiliations
- Shizuoka University (JP)
- Sanwa Kagaku Kenkyusho Co., Ltd. (Japan) (JP)
- Corresponding author
- Goda, Toshinao
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2007-05-31
- Volume
- 98
- Issue
- 4
- Pages
- 702-710
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2020098163
- Cited by
- 30
- References
- 38
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- miglitol, alpha-glucosidase inhibitors, type 2 diabetes, Goto-Kakizaki rats, blood glucose, HbA1c, pancreatic islets, beta-cell mass, islet fibrosis, oral glucose tolerance, hyperglycemia, 1-deoxynojirimycin
- MeSH terms
- Animals, Blood Glucose, Diabetes Mellitus, Hypoglycemic Agents, Islets of Langerhans, Male, Random Allocation, Treatment Outcome, Rats, Wistar, 1-Deoxynojirimycin, Imino Pyranoses, Rats
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