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Cited by 320

The DOI matches its Crossref record; 181 of the 181 references it cites were found in a registry or an index.

Dietary, physiological, genetic and pathological influences on postprandial lipid metabolism

Open access
Lopez-Miranda, José, Williams, Christine, Lairon, Denis·2007·British Journal of Nutrition

Abstract

Most of diurnal time is spent in a postprandial state due to successive meal intakes during the day. As long as the meals contain enough fat, a transient increase in triacylglycerolaemia and a change in lipoprotein pattern occurs. The extent and kinetics of such postprandial changes are highly variable and are modulated by numerous factors. This review focuses on factors affecting postprandial lipoprotein metabolism and genes, their variability and their relationship with intermediate phenotypes and risk of CHD. Postprandial lipoprotein metabolism is modulated by background dietary pattern as well as meal composition (fat amount and type, carbohydrate, protein, fibre, alcohol) and several lifestyle conditions (physical activity, tobacco use), physiological factors (age, gender, menopausal status) and pathological conditions (obesity, insulin resistance, diabetes mellitus). The roles of many genes have been explored in order to establish the possible implications of their variability in lipid metabolism and CHD risk. The postprandial lipid response has been shown to be modified by polymorphisms within the genes for apo A-I, A-IV, A-V, E, B, C-I and C-III, lipoprotein lipase, hepatic lipase, fatty acid binding and transport proteins, microsomal triglyceride transfer protein and scavenger receptor class B type I. Overall, the variability in postprandial response is important and complex, and the interactions between nutrients or dietary or meal compositions and gene variants need further investigation. The extent of present knowledge and needs for future studies are discussed in light of ongoing developments in nutrigenetics.

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Research works printed but not linked: 2

  1. 10.1161/01.ATV.20.5.1335 · doi:10.1161/01.atv.20.5.1335
  2. 10.1016/0378-1119(86)90383-5 · doi:10.1016/0378-1119(86)90383-5

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Metadata

Authors
Lopez-Miranda, J., Williams, C., & Lairon, D.
Venue
British Journal of Nutrition
Published
2007-09
Volume
98
Issue
3
Pages
458-473
ISSN
  • 0007-1145 (ISSN-L)
  • 1475-2662
OpenAlex
W2140045396
Cited by
320
References
181
FWCI
9.55
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Dietary, physiological, genetic and pathological influences on postprandial lipid metabolism. https://app.cochat.ai/papers/10.1017/s000711450774268x
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Lopez-Miranda, J., Williams, C., & Lairon, D. (2007). Dietary, physiological, genetic and pathological influences on postprandial lipid metabolism. British Journal of Nutrition. https://doi.org/10.1017/s000711450774268x

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