Dietary determinants for Hb-acrylamide and Hb-glycidamide adducts in Danish non-smoking women
Open accessAbstract
Acrylamide (AA) is a probable human carcinogen that is formed in heat-treated carbohydrate-rich foods. The validity of FFQ to assess AA exposure has been questioned. The aim of the present cross-sectional study was to investigate dietary determinants of Hb-AA and Hb-glycidamide (GA) adducts. The study included 537 non-smoking women aged 50-65 years who participated in the Diet, Cancer and Health cohort (1993-97). At study baseline, blood samples and information on dietary and lifestyle variables obtained from self-administered questionnaires were collected. From blood samples, Hb-AA and Hb-GA in erythrocytes were analysed by liquid chromatography/MS/MS. Dietary determinants were evaluated by multiple linear regression analyses adjusted for age and smoking behaviour among ex-smokers. The median for Hb-AA was 35 pmol/g globin (5th percentile 17, 95th percentile 89) and for Hb-GA 21 pmol/g globin (5th percentile 8, 95th percentile 49). Of the dietary factors studied, intakes of coffee and chips were statistically significantly associated with a 4 % per 200 g/d (95 % CI 2, 7; P < 0·0001) and an 18 % per 5 g/d (95 % CI 6, 31; P = 0·002) higher Hb-AA, respectively. This model explained 17 % of the variation in Hb-AA. Intakes of coffee and biscuits/crackers were statistically significantly associated with a 3 % per 200 g/d (95 % CI 1, 6; P = 0·005) and 12 % per 10 g/d (95 % CI 3, 23; P = 0·01) higher Hb-GA, respectively. This model explained 12 % of the variation in Hb-GA. In conclusion, only a few dietary determinants of Hb-AA and Hb-GA were identified. Thus, the present study implies that dietary intake measured by an FFQ explains only to a limited extent the variation in Hb-AA and Hb-GA concentrations.
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Isothiocyanates and acrylamide form adducts with blood albumin and hemoglobin, with half-lives of 3 to 8 weeks, and may be used as longer-term biomarkers.
“Some dietary compounds such as isothiocyanates and acrylamide also form adducts with blood albumin and hemoglobin (37,38), with half-lives varying between 3 and 8 wk, and may be used as longer-term biomarkers.”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [38]
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Cited by
Sorted by citations
The food metabolome: a window over dietary exposure
Scalbert, A., Brennan, L., Manach, C., Andres-Lacueva, C., Dragsted, L. O., Draper, J., Rappaport, S. M., van der Hooft, J. J., & Wishart, D. S. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.076133 · Cited by 519 · see citing works
Self-citation
- Authors
- Outzen, M., Egeberg, R., Dragsted, L., Christensen, J., Olesen, P. T., Frandsen, H., Overvad, K., Tjønneland, A., & Olsen, A.
- Affiliations
- Danish Cancer Society (DK)
- University of Copenhagen (DK)
- Technical University of Denmark (DK)
- Aarhus University (DK)
- Corresponding author
- Outzen, Malene
- ORCID
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2011-01-28
- Volume
- 105
- Issue
- 9
- Pages
- 1381-1387
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2155098072
- Cited by
- 11
- References
- 44
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2012: 3
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- Funders
- Danmarks Tekniske Universitet
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- acrylamide, glycidamide, dietary factors, coffee consumption, fried potato chips, dietary exposure assessment, non-smoking women
- MeSH terms
- Denmark, Diet, Epoxy Compounds, Feeding Behavior, Female, Hemoglobins, Humans, Middle Aged, Risk Factors, Case-Control Studies, Postmenopause, Acrylamide
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