Supplementation of diets with bovine colostrum influences immune function in dogs
Open accessAbstract
While the need for colostrum in neonates is well established, the systemic effect of feeding bovine colostrum (BC) to adult humans is gaining increasing attention. However, no systematic studies evaluating the immunomodulatory effect of BC in dogs have been reported. The aim of the present study was to evaluate the immunomodulatory effect of dietary supplementation of BC in dogs. The study was conducted in two phases: pre-test (8 weeks) and test (40 weeks), with twenty-four dogs (mean age 2.5 years) randomised into two groups. In the 'pre-test' phase, both groups were fed a nutritionally complete diet. At the end of the 'pre-test' phase, all dogs received a canine distemper virus (CDV) vaccine, and dogs in the 'test group' were switched to a diet supplemented with 0.1% spray-dried BC. Response to the CDV vaccine was evaluated by measuring vaccine-specific plasma IgG levels. Gut-associated lymphoid tissue response was assessed by measuring faecal IgA levels. Gut microbiota were evaluated by the temporal temperature gel electrophoresis methodology. Dogs fed the BC-supplemented diet demonstrated a significantly higher vaccine response and higher levels of faecal IgA when compared with the control group. Supplementing diets with BC also resulted in significantly increased gut microbiota diversity and stability in the test group. In conclusion, diets supplemented with BC significantly influence immune response in dogs.
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Bovine colostrum contains immune proteins that can modulate the immune system.
“While bovine colostrum not only contains a limited amount of milk oligosaccharides that may promote the growth of this particular bacteria [35, 36], it also contains an abundance of immune proteins, including immunoglobulins, lactoferrin and a range of cytokines, that can further modulate the microbiota [40] and the immune system [40–42].”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [41]
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- Authors
- Satyaraj, E., Reynolds, A., Pelker, R., Labuda, J., Zhang, P., & Sun, P.
- Affiliations
- Nestlé (United States) (US)
- Corresponding author
- Satyaraj, Ebenezer
- ORCID
- Satyaraj, Ebenezer
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2013-06-18
- Volume
- 110
- Issue
- 12
- Pages
- 2216-2221
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2103917652
- Cited by
- 43
- References
- 37
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 8 · 2022: 5 · 2021: 10 · 2020: 4 · 2019: 2 · 2018: 1 · 2016: 4 · 2014: 1 · 2013: 1
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Veterinary › Small Animals › Animal health and immunology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Animal Diversity and Health Studies
- Keywords
- bovine colostrum, dietary supplementation, dogs, immunomodulation, gut-associated lymphoid tissue, gut microbiota, microbiome diversity, microbiome stability
- MeSH terms
- Animals, Cattle, Colostrum, Distemper Virus, Canine, Dogs, Feces, Female, Immunoglobulin G, Immunologic Factors, Male, Pregnancy, Random Allocation, Viral Vaccines, Dietary Supplements, Gastrointestinal Tract, Microbiota
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