The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Vitamin D deficiency is associated with anaemia among African Americans in a US cohort
Abstract
Vitamin D deficiency is highly prevalent in the US population and is associated with numerous diseases, including those characterised by inflammatory processes. We aimed to investigate the link between vitamin D status and anaemia, hypothesising that lower vitamin D status would be associated with increased odds of anaemia, particularly anaemia with inflammation. A secondary aim was to examine the effects of race in the association between vitamin D status and anaemia. We conducted a cross-sectional analysis in a cohort of generally healthy adults in Atlanta, GA (n 638). Logistic regression was used to evaluate the association between vitamin D status and anaemia. Serum 25-hydroxyvitamin D (25(OH)D) < 50 nmol/l (compared to 25(OH)D ≥ 50 nmol/l) was associated with anaemia in bivariate analysis (OR 2·64, 95 % CI 1·43, 4·86). There was significant effect modification by race (P= 0·003), such that blacks with 25(OH)D < 50 nmol/l had increased odds of anaemia (OR 6·42, 95 % CI 1·88, 21·99), v. blacks with 25(OH)D ≥ 50 nmol/l, controlling for potential confounders; this association was not apparent in whites. When categorised by subtype of anaemia, blacks with 25(OH)D < 50 nmol/l had significantly increased odds of anaemia with inflammation than blacks with serum 25(OH)D ≥ 50 nmol/l (OR 8·42, 95 % CI 1·96, 36·23); there was no association with anaemia without inflammation. In conclusion, serum 25(OH)D < 50 nmol/l was significantly associated with anaemia, particularly anaemia with inflammation, among blacks in a generally healthy adult US cohort.
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“The lack of association between vitamin D status and the two main hematology parameters used to diagnose anemia—Hb and HCT—and the higher mean values of RBC, in the group with reduced vitamin D concentrations in our study, may have resulted from the fact that only healthy athletes (without any symptoms of acute phase reaction) were studied. This confirms the hypothesis that vitamin D deficiency”
From The Association between Iron and Vitamin D Status in Female Elite Athletes (2018) · cites this paper as [45]
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Cited by
The Association between Iron and Vitamin D Status in Female Elite Athletes
Malczewska-Lenczowska, J., Sitkowski, D., Surała, O., Orysiak, J., Szczepańska, B., & Witek, K. (2018) · Nutrients · doi:10.3390/nu10020167 · Cited by 76
Metadata
- Authors
- Smith, E. M., Alvarez, J. A., Martin, G. S., Zughaier, S. M., Ziegler, T. R., & Tangpricha, V.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2015-04-16
- Volume
- 113
- Issue
- 11
- Pages
- 1732-1740
- ISSN
- 0007-1145
- 1475-2662
- Cited by
- 41
- References
- 8
- Language
- en
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