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Cited by 785

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

The maintenance of genetic variability by mutation in a polygenic character with linked loci

Open access
Lande, Russell·1975·Genetical Research
DOI 10.1017/s0016672300016037
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Abstract

SUMMARY: It is assumed that a character under stabilizing selection is determined genetically by n linked, mutable loci with additive effects and a range of many possible allelic effects at each locus. A general qualitative feature of such systems is that the genetic variance for the character is independent of the linkage map of the loci, provided linkage is not very tight. A particular detailed model shows that certain aspects of the genetic system are moulded by stabilizing selection while others are selectively neutral. With reference to experimental data on characters of Drosophila flies, maize, and mice, it is concluded that large amounts of genetic variation can be maintained by mutation in polygenic characters even when there is strong stabilizing selection. The properties of the model are compared with those of heterotic models with linked loci.

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Metadata

Authors
Lande, R.
Venue
Genetical Research
Publisher
Hindawi Limited
Published
1975-12
Volume
26
Issue
3
Pages
221-235
ISSN
  • 0016-6723 (ISSN-L)
  • 1469-5073
DOI
10.1017/s0016672300016037
OpenAlex
W2159707462
Cited by
785
References
2
FWCI
4.15
Type
journal article
Language
en
Open access
bronze

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