The coalescent process in models with selection, recombination and geographic subdivision
Open accessAbstract
Summary: A population genetic model with a single locus at which balancing selection acts and many linked loci at which neutral mutations can occur is analysed using the coalescent approach. The model incorporates geographic subdivision with migration, as well as mutation, recombination, and genetic drift of neutral variation. It is found that geographic subdivision can affect genetic variation even with high rates of migration, providing that selection is strong enough to maintain different allele frequencies at the selected locus. Published sequence data from the alcohol dehydrogenase locus of Drosophila melanogaster are found to fit the proposed model slightly better than a similar model without subdivision.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A tree that strongly elongates indicates balancing selection.
“In contrast, a tree that strongly elongates indicates BS 60 .”
From A Chronological Atlas of Natural Selection in the Human Genome during the Past Half-million Years (2015) · cites this paper as [60]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Principles of Population Genetics.
Cormack, R. M., Hartl, D. L., & Clark, A. G. (1990) · Biometrics · doi:10.2307/2531471 · Cited by 5,283 · see citing works
On the number of segregating sites in genetical models without recombination
Watterson, G. A. (1975) · Theoretical Population Biology · doi:10.1016/0040-5809(75)90020-9 · Cited by 3,968 · see citing works
A Test of Neutral Molecular Evolution Based on Nucleotide Data
Hudson, R. R., Kreitman, M., & Aguadé, M. (1987) · Genetics · doi:10.1093/genetics/116.1.153 · Cited by 1,759 · see citing works
Self-citationKimura, M. (1969) · Genetics · doi:10.1093/genetics/61.4.893 · Cited by 837 · see citing works
Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster
Kreitman, M. (1983) · Nature · doi:10.1038/304412a0 · Cited by 699 · see citing works
Line-of-descent and genealogical processes, and their applications in population genetics models
Tavaré, S. (1984) · Theoretical Population Biology · doi:10.1016/0040-5809(84)90027-3 · Cited by 581 · see citing works
The coalescent process in models with selection and recombination.
Hudson, R. R., & Kaplan, N. L. (1988) · Genetics · doi:10.1093/genetics/120.3.831 · Cited by 434 · see citing works
Self-citationOakeshott, J. G., Gibson, J. B., Anderson, P. R., et al. (1982) · Evolution · doi:10.1111/j.1558-5646.1982.tb05013.x · Cited by 294 · see citing works
The coalescent process in models with selection
Kaplan, N. L., Darden, T. A., & Hudson, R. R. (1988) · Genetics · doi:10.1093/genetics/120.3.819 · Cited by 283 · see citing works
Self-citationA First Course in Stochastic Processes.
Port, S. C., & Karlin, S. (1968) · American Mathematical Monthly · doi:10.2307/2314395 · Cited by 271 · see citing works
Vigue, C. L., & Johnson, F. M. (1973) · Biochemical Genetics · doi:10.1007/bf00485735 · Cited by 192 · see citing works
A First Course in Stochastic Processes
(1968) · Elsevier eBooks · doi:10.1016/c2013-0-12346-x · Cited by 145 · see citing works
The average number of sites separating DNA sequences drawn from a subdivided population
Slatkin, M. (1987) · Theoretical Population Biology · doi:10.1016/0040-5809(87)90038-4 · Cited by 102 · see citing works
EXCESS POLYMORPHISM AT THE Adh LOCUS IN DROSOPHILA MELANOGASTER
Kreitman, M., & Aguadé, M. (1986) · Genetics · doi:10.1093/genetics/114.1.93 · Cited by 90 · see citing works
Simmons, G. M., Kreitman, M., Quattlebaum, W. F., & Miyashita, N. T. (1989) · Evolution · doi:10.1111/j.1558-5646.1989.tb04235.x · Cited by 33 · see citing works
Simmons, G. M., Kreitman, M., Quattlebaum, W. F., et al. (1989) · Evolution · doi:10.2307/2409215 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A Chronological Atlas of Natural Selection in the Human Genome during the Past Half-million Years
Zhou, H., Hu, S., Matveev, R., Yu, Q., Li, J., Khaitovich, P., Jin, L., Lachmann, M., Stoneking, M., Fu, Q., et al. (2015) · doi:10.1101/018929 · Cited by 28 · see citing works
- Authors
- Kaplan, N., Hudson, R. R., & Iizuka, M.
- Affiliations
- National Institute of Environmental Health Sciences (US)
- University of California, Irvine (US)
- Chikushi Jogakuen University (JP)
- Corresponding author
- Kaplan, Norman
- Venue
- Genetical Research
- Publisher
- Wiley
- Published
- 1991-02
- Volume
- 57
- Issue
- 1
- Pages
- 83-91
- ISSN
- 0016-6723 (ISSN-L)
- 1469-5073
- OpenAlex
- W2102177650
- Cited by
- 71
- References
- 16
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 8 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genetics Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Keywords
- coalescent, balancing selection, recombination, migration, linked loci, neutral variation, genetic drift, allele frequency, alcohol dehydrogenase, Drosophila melanogaster, population genetic models
- MeSH terms
- Alcohol Dehydrogenase, Animals, Drosophila melanogaster, Gene Frequency, Mathematics, Models, Genetic, Mutation, Recombination, Genetic, Selection, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
