Pattern of selective constraint in C. elegans and C. briggsae genomes
Open accessAbstract
Similarity between related genomes may carry information on selective constraint in each of them. We analysed patterns of similarity between several homologous regions of Caenorhabditis elegans and C. briggsae genomes. All homologous exons are quite similar. Alignments of introns and of intergenic sequences contain long gaps, segments where similarity is low and close to that between random sequences aligned using the same parameters, and segments of high similarity. Conservative estimates of the fractions of selectively constrained nucleotides are 72%, 17% and 18% for exons, introns and intergenic sequences, respectively. This implies that the total number of constrained nucleotides within non-coding sequences is comparable to that within coding sequences, so that at least one-third of nucleotides in C. elegans and C. briggsae genomes are under strong stabilizing selection.
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Worm estimates of conserved fractions of coding, intronic, and intergenic regions are fairly similar to estimates from an early C. elegans/C. briggsae comparative study.
“In worms, our estimates of the fractions of coding regions, introns, and intergenic regions that are conserved are fairly similar to estimates based on an early comparative study of C. elegans and C. briggsae (Shabalina and Kondrashov 1999)”
From Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes (2005) · cites this paper as Shabalina and Kondrashov 1999
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Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
Siepel, A., Bejerano, G., Pedersen, J. S., Hinrichs, A. S., Hou, M., Rosenbloom, K., Clawson, H., Spieth, J., Hillier, L. W., Richards, S., et al. (2005) · Genome Research · doi:10.1101/gr.3715005 · Cited by 4,408 · see citing works
The distribution of fitness effects of new deleterious amino acid mutations in humans.
Eyre-Walker, A., Woolfit, M., & Phelps, T. (2006) · Genetics · doi:10.1534/genetics.106.057570 · Cited by 377 · see citing works
- Authors
- SHABALINA, S. A., & KONDRASHOV, A. S.
- Affiliations
- Cornell University (US)
- Venue
- Genetical Research
- Publisher
- Hindawi Limited
- Published
- 1999-08
- Volume
- 74
- Issue
- 1
- Pages
- 23-30
- ISSN
- 0016-6723 (ISSN-L)
- 1469-5073
- OpenAlex
- W2040083865
- Cited by
- 94
- References
- 1
- Citations by year
- 2024: 3 · 2019: 2 · 2018: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genetics Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9417753)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- selective constraint, stabilizing selection, Caenorhabditis elegans, Caenorhabditis briggsae, homologous regions, intergenic regions, non-coding sequences, comparative genomics
- MeSH terms
- Animals, Base Sequence, Caenorhabditis, Molecular Sequence Data, Species Specificity, Genome, Caenorhabditis elegans, DNA, Helminth
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