The relationship between BMI and metabolomic profiles: a focus on amino acids
Open accessAbstract
The role of metabolomics in the field of nutrition is continuing to grow and it has the potential to assist in the understanding of metabolic regulation and explain how minor perturbations can have a multitude of biochemical endpoints. It is this development, which creates the potential to provide the knowledge necessary to facilitate a more targeted approach to nutrition. In recent years, there has been interest in applying metabolomics to examine alterations in the metabolic profile according to weight gain/obesity. Emerging from these studies is the strong evidence that alterations in the amino acid (AA) profiles are associated with obesity. Several other studies have also shown a relationship between branched-chain amino acids (BCAA), obesity and insulin resistance. The present review focuses on the proposed link between AA and in particular BCAA, obesity and insulin resistance. In conclusion, a wealth of information is accumulating to support the role of AA, and in particular of the BCAA, in obesity.
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Most amino acids have been found to be stable during two thaw-freeze cycles.
“However, most amino acids have been found to be stable during two thaw–freeze cycles,33 and in the current study, the number of thaw–freeze cycles was independent of diet group.”
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References 30 · Cited by 81
- Authors
- Morris, C., O'Grada, C., Ryan, M., Roche, H. M., Gibney, M. J., Gibney, E. R., & Brennan, L.
- Affiliations
- University College Dublin (IE)
- Corresponding author
- Brennan, Lorraine
- Venue
- Proceedings of the Nutrition Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-08-06
- Volume
- 71
- Issue
- 4
- Pages
- 634-638
- ISSN
- 0029-6651 (ISSN-L)
- 1475-2719
- OpenAlex
- W2081016894
- Cited by
- 81
- References
- 30
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 10 · 2017: 4 · 2016: 12 · 2015: 12 · 2014: 5 · 2013: 6 · 2012: 1
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of The Nutrition Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Health Research Board
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- body mass index, obesity, amino acids, branched-chain amino acids, metabolite profiles, insulin resistance, weight gain, metabolic regulation
- MeSH terms
- Amino Acids, Amino Acids, Branched-Chain, Humans, Insulin Resistance, Obesity, Body Mass Index, Metabolomics, Metabolome
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