Cited by 234Bipolar Disorder and TreatmentMental Health Research TopicsSchizophrenia research and treatment

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Social rhythm disruption and stressful life events in the onset of bipolar and unipolar episodes

MALKOFF-SCHWARTZ, S., FRANK, E., ANDERSON, B. P., HLASTALA, S. A., LUTHER, J. F., SHERRILL, J. T., HOUCK, P. R., KUPFER, D. J.·2000·Psychological Medicine

DOI 10.1017/s0033291799002706

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Abstract

Background. An association between social rhythm disruption (SRD) and onset of manic episodes has recently been observed. Whether other types of bipolar (depressive and cycling) or unipolar depressive episodes are similarly related to SRD is unclear, as is the association between severely threatening life events and onset of bipolar manic, depressed and cycling episodes. Methods. Bipolar patients with purely manic ( N = 21), purely depressed ( N = 21) and cycling ( N = 24) episodes, and 44 patients with recurrent unipolar depression, were interviewed with the Bedford College Life Events and Difficulties Schedule. The presence of severe and SRD events during the year prior to index episode onset was then determined. Results. More manic than cycling and unipolar subjects experienced SRD events during 8- and 20-week pre-onset periods, and severe events during 20-week pre-onset periods. Controlling for age and prior number of episodes left most findings unchanged. An earlier finding of more manic subjects with SRD events in an 8-week pre-onset versus control period was also replicated. Conclusions. It appears that manic onsets are influenced by stressful life events, especially those involving SRD, in a unique manner compared to onsets of other types of bipolar and unipolar episodes. Onset of bipolar cycling episodes, in contrast, seems to be relatively unaffected by SRD or severe life events. These findings refine the hypothesis that SRD may precipitate onset of affective episodes to be specific to manic onsets.

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Background
Psychometric Properties of Behavioral Checklist for Coping with Stress in Patients with Mood Disorders
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Envy
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Le poids des événements de vie dans les troubles unipolaires et bipolaires
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Kupfer, D. J., & Frank, E. (2023) · SLEEP Advances · doi:10.1093/sleepadvances/zpad002 · Cited by 1
Self-citation
Stressful life events and social support in Bipolar disorder Cross-sectional study from South India shows stressful life events and greater severity of stress in the pre-onset period as risk factors for relapse
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PIDKORYTOV, V., Syerikova, O. I., Serikova, O. S., et al. (2023) · Ukrains kyi Visnyk Psykhonevrolohii · doi:10.36927/2079-0325-v31-is2-2023-8 · Cited by 1
Serum kynurenine metabolites and cytokine levels: diagnostic and predictive implications in acute manic episodes of bipolar disorder
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Self-citation
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Interpersonal Psychotherapy*
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Authors: MALKOFF-SCHWARTZ, S., FRANK, E., ANDERSON, B. P., HLASTALA, S. A., LUTHER, J. F., SHERRILL, J. T., HOUCK, P. R., & KUPFER, D. J.
Affiliations: University of Pittsburgh (US)
ORCID: FRANK, E.
LUTHER, J. F.
KUPFER, D. J.
Venue: Psychological Medicine
Publisher: Cambridge University Press (CUP)
Published: 2000-09
Volume: 30
Issue: 5
Pages: 1005-1016
ISSN: 0033-2917 (ISSN-L)
1469-8978
DOI: 10.1017/s0033291799002706
OpenAlex: W2085710201
Cited by: 234
References: 0
Citations by year: 2026: 1 · 2025: 9 · 2024: 10 · 2023: 15 · 2022: 9 · 2021: 6 · 2020: 10 · 2019: 5 · 2018: 10 · 2017: 7 · 2016: 8 · 2015: 15 · 2014: 8 · 2013: 11 · 2012: 9
FWCI: 2.56
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 46 d)
Locations: Psychological Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 29618, MH30915)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: life events, bipolar disorder, major depressive disorder
MeSH terms: Adult, Aged, Bipolar Disorder, Major Depressive Disorder, Female, Humans, Life Change Events, Male, Middle Aged, Recurrence, Risk Factors

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Social rhythm disruption and stressful life events in the onset of bipolar and unipolar episodes

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