The DOI matches its Crossref record; 15 of the 16 references it cites were found in a registry or an index.
Comparison of antimicrobial effects of dexmedetomidine and etomidate-lipuro with those of propofol and midazolam
Abstract
BACKGROUND AND OBJECTIVES: The aim of our study was to investigate the antimicrobial effects of dexmedetomidine and etomidate-lipuro, and to compare these effects with those of midazolam and propofol on Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa, Acinetobacter baumannii and extended-spectrum beta-lactamase Escherichia coli ( E. coli ESBL). METHODS: All hypnotic dilutions were exposed to micro-organisms for 0, 30, 60, 120 and 240 min at room temperature in vitro. The inoculums taken from diluted suspensions were re-inoculated on blood agar and incubated for 18-24 h at 35 degrees C after which a count of the colonies was compared. RESULTS: Midazolam reduced the viable cells of S. aureus at 30, 60, 120 and 240 min, and also completely inhibited the growth of E. coli, P. aeroginosa, A. baumannii and E. coli ESBL. Dexmedetomidine, etomidate-lipuro and propofol, however, did not inhibit any of the micro-organisms tested. CONCLUSION: In vitro, midazolam had an antimicrobial effect on E. coli, P. aeroginosa, A. baumannii and E. coli ESBL. Like propofol and dexmedetomidine, etomidate-lipuro had no antimicrobial effect on any of the micro-organisms tested.
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In the citing paper
“| Midazolam (promotes the action of GABA) | C. albicans, S. aureus, E. faecalis, E. coli, P. aeruginosa, A. baumanii | 95 µM-12 mM (31.25-4000 µg/mL) | Inhibits growth, hyphae formation, and biofilm growth, inhibits bacterial growth | [76-78] |”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [78]
In the citing paper
“| Midazolam (promotes the action of GABA) | C. albicans, S. aureus, E. faecalis, E. coli, P. aeruginosa, A. baumanii | 95 µM-12 mM (31.25-4000 µg/mL) | Inhibits growth, hyphae formation, and biofilm growth, inhibits bacterial growth | [76-78] |”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [78]
Citations
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Cited by
Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications
Caldara, M., & Marmiroli, N. (2021) · Pharmaceuticals · doi:10.3390/ph14090915 · Cited by 54
Sá, L. G. D. A. V., da Silva, C. R., Neto, J. B. D. A., do Nascimento, F. B. S. A., Barroso, F. D. D., da Silva, L. J., Cabral, V. P. D. F., Barbosa, A. D., Silva, J., Marinho, E. S., et al. (2020) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001241 · Cited by 25
Antimicrobial effects of two anaesthetic agents: Dexmedetomidine and midazolam
Ayoglu, H., Kulah, C., & Turan, I. (2008) · Anaesthesia and Intensive Care · doi:10.1177/0310057x0803600508 · Cited by 21
Emerging Anesthetic Nanomedicines: Current State and Challenges
Zhang, S., Wang, Y., Zhang, S., Huang, C., Ding, Q., Xia, J., Wu, D., & Gao, W. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s417855 · Cited by 19
Dugan, A. L., Gregerson, K. A., Neely, A. N., Gardner, J., Noel, G. J., Babcock, G. F., & Horseman, N. D. (2010) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e3181cb8e82 · Cited by 19
Metadata
- Authors
- Keleş, G. T., Kurutepe, S., Tok, D., Gazi, H., & Dinç, G.
- Affiliations
- Manisa Celal Bayar University (TR)
- Corresponding author
- Keleş, G. T.
- Tok, D.
- Venue
- European Journal of Anaesthesiology
- Published
- 2006-12
- Volume
- 23
- Issue
- 12
- Pages
- 1037-1040
- ISSN
- 0265-0215 (ISSN-L)
- OpenAlex
- W2110582171
- Cited by
- 22
- References
- 16
- Citations by year
- 2025: 2 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2017: 2 · 2014: 3 · 2013: 3
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Anaesthesiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- dexmedetomidine, propofol, midazolam, antimicrobial activity, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, extended-spectrum beta-lactamase, anesthetic agents, bacterial growth inhibition
- MeSH terms
- Adrenergic alpha-Agonists, Anti-Infective Agents, Drug Evaluation, Preclinical, Equipment Contamination, Escherichia coli, Etomidate, Humans, Midazolam, Pseudomonas aeruginosa, Staphylococcus aureus, Temperature, Time Factors, Propofol, Anesthetics, Intravenous, Dexmedetomidine, Acinetobacter baumannii
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- CoChat. (2026). Citation check: Comparison of antimicrobial effects of dexmedetomidine and etomidate-lipuro with those of propofol and midazolam. https://app.cochat.ai/papers/10.1017/s0265021506000949
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- Keleş, G. T., Kurutepe, S., Tok, D., Gazi, H., & Dinç, G. (2006). Comparison of antimicrobial effects of dexmedetomidine and etomidate-lipuro with those of propofol and midazolam. European Journal of Anaesthesiology. https://doi.org/10.1017/s0265021506000949
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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