The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mechanisms Underlying Functional Recovery Following Stroke
Open accessAbstract
This article reviews recent evidence from animal experiments indicating that there is considerable potential for reorganization of representations and functions in sensory and motor cortex following localized lesions or various manipulations of peripheral target structures. Three major mechanisms for this plastic reorganization are considered: unmasking of existing but functionally inactive pathways, sprouting of fibers from surviving neurons and formation of new synapses, and redundancy of CNS circuitry allowing alternative pathways to take over functions. Studies using positron emission tomography or transcranial magnetic stimulation suggest that similar forms of neuroplasticity may occur in the human brain and could contribute to functional recovery following stroke. The potential therapeutic implications are discussed.
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Citations
Cites
Functional architecture of basal ganglia circuits: neural substrates of parallel processing
Alexander, G. E., & Crutcher, M. D. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90107-l · Cited by 4,131
Expression of c- fos Protein in Brain: Metabolic Mapping at the Cellular Level
Sagar, S. M., Sharp, F. R., & Curran, T. (1988) · Science · doi:10.1126/science.3131879 · Cited by 1,925
Cited by
Understanding the pattern of functional recovery after stroke: Facts and theories
Kwakkel, G., Kollen, B., & Lindeman, E. (2004) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2004-00282 · Cited by 727
Extensive Cortical Rewiring after Brain Injury
Dancause, N., Barbay, S., Frost, S. B., Plautz, E. J., Chen, D., Zoubina, E. V., Stowe, A. M., & Nudo, R. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3256-05.2005 · Cited by 704
Is there a future for therapeutic use of transcranial magnetic stimulation?
Ridding, M. C., & Rothwell, J. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2169 · Cited by 687
Biernaskie, J., & Corbett, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05272.2001 · Cited by 607
Neuromuscular electrical stimulation in neurorehabilitation
Sheffler, L. R., & Chae, J. (2007) · Muscle & Nerve · doi:10.1002/mus.20758 · Cited by 529
Metadata
- Authors
- Lee, R. G., & Donkelaar, P. V.
- Venue
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
- Publisher
- Cambridge University Press (CUP)
- Published
- 1995-11
- Volume
- 22
- Issue
- 4
- Pages
- 257-263
- ISSN
- 0317-1671 (ISSN-L)
- 2057-0155
- OpenAlex
- W2411623662
- Cited by
- 158
- References
- 2
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Mechanisms Underlying Functional Recovery Following Stroke. https://app.cochat.ai/papers/10.1017/s0317167100039445
- The paper
- Lee, R. G., & Donkelaar, P. V. (1995). Mechanisms Underlying Functional Recovery Following Stroke. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. https://doi.org/10.1017/s0317167100039445
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
