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Aetiologies and risk factors for neonatal sepsis and pneumonia mortality among Alaskan infants
Open accessAbstract
We evaluated all fatal neonatal sepsis and pneumonia cases occurring in Alaska during 1992–2000. Risk factors were evaluated using a database of all births occurring during the study period. Of 32 cases, group B streptococcus (GBS) was isolated from 21% (all <7 days of age), Candida spp. from 19% (all >7 days of age), non-GBS Gram-positive bacteria from 50% (53% <7 days of age), and Gram-negative infections from 38% (58% <7 days of age). Infants born at <37 weeks gestation accounted for 72% of cases and had an increased risk of GBS [rate ratio (RR) 9·1, 95% confidence interval (CI) 2·0–41] and non-GBS (RR 40, 95% CI 16–101) disease. Neonatal sepsis mortality has become an outcome concentrated among pre-term infants. Aetiologies include GBS during the early neonatal period, Candida spp. during the late neonatal period, and other bacteria during both periods.
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A diagnosis of neonatal sepsis based only on microbiological findings will under estimate the true burden of neonatal sepsis.
“A diagnosis of neonatal sepsis based only on microbiological findings will under estimate the true burden of neonatal sepsis [7].”
From A three year descriptive study of early onset neonatal sepsis in a refugee population on the Thailand Myanmar border (2013) · cites this paper as [7]
The Discussion reports that relying solely on sterile-site isolates missed approximately one third of neonatal sepsis/pneumonia deaths in the Alaskan study and could underestimate the importance of neonatal sepsis. This supports the concern about underestimation, but the paper's quantified finding concerns fatal cases and a sterile-site-only definition, not every diagnosis based solely on microbiological findings. (LLM, conf=0.86)
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Metadata
- Authors
- GESSNER, B. D., CASTRODALE, L., & SORIANO-GABARRO, M.
- Affiliations
- Alaska Department of Health and Social Services (US)
- ORCID
- GESSNER, B. D.
- Venue
- Epidemiology and Infection
- Publisher
- Cambridge University Press (CUP)
- Published
- 2005-05-09
- Volume
- 133
- Issue
- 5
- Pages
- 877-881
- ISSN
- 0950-2688 (ISSN-L)
- 1469-4409
- PMC
- PMC2870319
- OpenAlex
- W2106707180
- Cited by
- 16
- References
- 27
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2013: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Epidemiology and Infection (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Health and Human Services
- Health Resources and Services Administration
- U.S. Public Health Service (H18MC-00004-11)
- Maternal and Child Health Bureau
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and Neonatal Healthcare
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Keywords
- neonatal sepsis, neonatal pneumonia, infant mortality, Streptococcus agalactiae, preterm infants, risk factors, Candida, Gram-positive bacteria, Gram-negative bacteria, neonatal infection
- MeSH terms
- Alaska, Candida, Candidiasis, Gram-Negative Bacteria, Gram-Positive Bacteria, Humans, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Pneumonia, Risk Factors, Incidence, Databases, Factual, Gram-Negative Bacterial Infections, Gram-Positive Bacterial Infections, Sepsis
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